α-Tocopherol increases caspase-3 up-regulation and apoptosis by β-carotene cleavage products in human neutrophils

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1772, Issue 9, 2007, Pages 1052-1056

  Salerno, C ^a   Capuozzo, E ^a   Crifo C ^a   Siems, W ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b KortexMed Institute of Medical Education   (Germany)

Author keywords

Apoptosis; Carotenoid; Neutrophil; Oxidative stress; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; BETA IONONE; CASPASE 3; PEROXYNITRITE; RETINOL; URIC ACID;

APOPTOSIS; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; NEUTROPHIL; PRIORITY JOURNAL; UPREGULATION;

ALPHA-TOCOPHEROL; APOPTOSIS; BETA CAROTENE; CASPASE 3; CHROMATIN; DNA FRAGMENTATION; HUMANS; NEUTROPHILS; NORISOPRENOIDS; UP-REGULATION; VITAMIN A;

EID: 34548188083     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2007.05.008     Document Type: Article

References (39)

1. Mayne S.T. Beta carotene, carotenoids, and disease prevention in humans. FASEB J. 10 (1996) 690-701
2. Hennekens C.H., Buring J.E., Manson J.E., Stampfer M., Rosner B., Cook N.R., Belanger C., LaMotte F., Gaziano J.M., Ridker P.M., Willett W., and Peto R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med. 334 (1996) 1145-1149
3. Omenn G.S., Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Glass A., Keogh J.P., Meyskens F.L., Valanis B., Williams J.H., Barnhart S., Cherniack M.G., Brodkin C.A., and Hammar S. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J. Natl. Cancer Inst. 88 (1996) 1550-1559
4. Bowen D.J., Thornquist M., Anderson K., Barnett M., Powell C., Goodman G., and Omenn G. Carotene and Retinol Efficacy Trial. Stopping the active intervention: CARET. Control. Clin. Trials 24 (2003) 39-50
5. Bendich A. From 1989 to 2001: what have we learned about the "biological actions of beta-carotene"?. J. Nutr. 134 (2004) 225S-230S
6. Young A.J., and Lowe G.M. Antioxidant and pro-oxidant properties of carotenoids. Arch. Biochem. Biophys. 385 (2001) 20-27
7. Siems W., Sommerburg O., Schild L., Augustin W., Langhans C.D., and Wiswedel I. Beta-carotene cleavage products induce oxidative stress in vitro by impairing mitochondrial respiration. FASEB J. 16 (2002) 1289-1291
8. Edge R., and Truscott T.G. Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins E and C. Nutrition 13 (1997) 992-994
9. Böhm F., Edge R., McGarvey D.J., and Truscott T.G. Beta-carotene with vitamins E and C offers synergistic cell protection against NOx. FEBS Lett. 436 (1998) 387-389
10. Siems W., Capuozzo E., Crifò C., Sommerburg O., Langhans C.D., Schlipalius L., Wiswedel I., Kraemer K., and Salerno C. Carotenoid cleavage products modify respiratory burst and induce apoptosis of human neutrophils. Biochim. Biophys. Acta 1639 (2003) 27-33
11. Robinson K.M., Morre J.T., and Beckman J.S. Triuret: a novel product of peroxynitrite-mediated oxidation of urate. Arch. Biochem. Biophys. 423 (2004) 213-217
12. Sommerburg O., Langhans C.-D., Arnhold J., Leichsenring M., Salerno C., Crifò C., Hoffmann G.F., Debatin K.-M., and Siems W.G. β-Carotene cleavage products after oxidation mediated by hypochlorous acid-A model for neutrophil-derived degradation. Free Radic. Biol. Med. 35 (2003) 1480-1490
13. Ferrante A., and Thong Y.H. Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leukocytes from human peripheral blood by the Ficoll-Hypaque method. J. Immunol. Methods 36 (1980) 109-117
14. Nicholson D.M., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., and Lazebnik Y.A. Identification and inhibition of the ICE/CED-3 proteased necessary for mammalian apoptosis. Nature 376 (1995) 37-43
15. Chandler J.M., Cohen G.M., and MacFarlane M. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J. Biol. Chem. 273 (1998) 10815-10818
16. Spitsin S.V., Scott G.S., Mikheeva T., Zborek A., Kean R.B., Brimer C.M., Koprowski H., and Hooper D.C. Comparison of uric acid and ascorbic acid in protection against EAE. Free Radic. Biol. Med. 33 (2002) 1363-1371
17. Miyoshi N., Naniwa K., Kumagai T., Uchida K., Osawa T., and Nakamura Y. α-Tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli. Biochem. Biophys. Res. Commun. 334 (2005) 466-473
18. Alija A.J., Bresgen N., Sommerburg O., Siems W., and Eckl P.M. Cytotoxic and genotoxic effects of beta-carotene breakdown products on primary rat hepatocytes. Carcinogenesis 25 (2004) 827-831
19. Alija A.J., Bresgen N., Sommerburg O., Langhans C.D., Siems W., and Eckl P.M. Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes. Carcinogenesis 27 (2006) 1128-1133
20. Kane D.J., Sarafian T.A., Anton R., Hahn H., Butler G.E., Selverstone V.J., Örd T., and Breseden D.E. Bel-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262 (1993) 1274-1277
21. Jacobson M.D. Reactive oxygen species and programmed cell death. TIBS 21 (1996) 83-86
22. Truscott T.G., McGarvey D., Lambert C., Hill T., Tinkler J., Conn P., Bohm F., Land E.J., and Schalch W. The interaction of carotenoids with reactive oxy-species. Biochem. Soc. Trans. 23 (1995) 252S
23. Cantrell A., McGarvey D.J., Truscott T.G., Rancan F., and Bohm F. Singlet oxygen quenching by dietary carotenoids in a model membrane environment. Arch. Biochem. Biophys. 412 (2003) 47-54
24. Palozza P., Calviello G., Serini S., Maggiano N., Lanza P., Ranelletti F.O., and Bartoli G.M. β-Carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells. Free Radic. Biol. Med. 30 (2001) 1000-1007
25. Müller K., Carpenter K.H., Challis I.R., Skepper J.N., and Arends M.J. Caroteoids induce apoptosis in the T-lymphoblast cell line Jurkat E6.1. Free Radic. Res. 36 (2002) 791-802
26. Konta T., Xu Q., Furusu A., Nakayama K., and Kitamura M. Selective roles of retinoic acid receptor and retinoid X receptor in the suppression of apoptosis by all-trans-retinoic acid. J. Biol. Chem. 276 (2001) 12697-12701
27. Lowe G.M., Booth L.A., Young A.J., and Bilton R.F. Lycopene and β-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic. Res. 30 (1999) 141-151
28. Cacciola S.A., Cohen L.A., and Kashfi K. Lycopene inhibits proliferation and regulates cyclooxygenase-2 gene expression in neoplastic rat mammari epithelial cells. FASEB J. 13 (1999) A551
29. Muto Y., Fujii J., Shidoji Y., Moriwaki H., Kawaguchi T., and Noda T. Growth-retardation in human cervical dysplasia-derived cell lines by beta-carotene through down-regulation of epidermal growth-factor receptor. Am. J. Clin. Nutr. 62 (1995) S1535-S1540
30. Ricciarelli R., Zingg J.M., and Azzi A. Vitamin E: protective role of a Janus molecule. FASEB J. 15 (2001) 2314-2325
31. Traber M.G., and Sies H. Vitamin E in humans: demand and delivery. Annu. Rev. Nutr. 16 (1996) 321-347
32. Hu J.J., Chi C.X., Frenkel K., Smith B.N., Henfelt J.J., Berwick M., Mahabir S., and D'Agostino R.B. β-Tocopherol dietary supplement decreases titers of antibody against 5-hydroxymethyl-2′-deoxyuridine. Cancer Epidemiol., Biomarkers Prev. 8 (1999) 693-698
33. Thurmann P.A., Steffen J., Zwernemann C., Aebischer C.P., Cohn W., Wendt G., and Schalch W. Plasma concentration response to drinks containing beta-carotene as carrot juice or formulated as a water dispersed powder. Eur. J. Nutr. 41 (2002) 228-235
34. Stahl W., Heinrich U., Wiseman S., Eichler O., Sies H., and Tronnier H. Dietary tomato paste protects against ultraviolet light-induced erythema in humans. J. Nutr. 131 (2001) 1449-1451
35. Chelchowska M., Laskowska-Klita T., and Szymborski J. Level of retinol and beta-carotene in plasma of smoking and non-smoking women. Wiad. Lek. 54 (2001) 248-254
36. Papi A., Luppi F., Franco F., and Fabbri L.M. Pathophysiology of exacerbations of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 3 (2006) 245-251
37. S. Battaglia, T. Mauad, A.M. van Schadewijk, A.M. Vignola, K.F. Rabe, V. Bellia, P.J. Sterk, P.S. Hiemstra, Differential distribution of inflammatory cells in large and small airways in smokers. J. Clin. Pathol. (in press) (published online 17 Aug 2006).
38. Tolleson W.H., Cherng S.H., Xia Q., Boudreau M., Yin J.J., Wamer W.G., Howard P.C., Yu H., and Fu P.P. Photodecomposition and phototoxicity of natural retinoids. Int. J. Environ. Res. Public Health 2 (2005) 147-155
39. Stanfield J.W., Feldman S.R., and Levitt J. Sun protection of a hydroquinone 4%/retinol 0.3% preparation containing sunscreens. J. Drugs Dermatol. 5 (2006) 321-324