Methods for the synthesis of carbon-13 labelled acids and esters

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 50, Issue 5-6, 2007, Pages 338-341

  Jordan, Angela C ^a   Axford, Lorraine C ^b   Harding, John R ^a   O'Connell, Yvonne ^b   Simpson, Thomas J ^b   Willis, Christine L ^b  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Aldol reaction; Carbon 13 labelling; Horner Wadsworth Emmons; Knoevenagel

Indexed keywords

CARBON; KETONES;

ALDOL REACTIONS; CARBON-13; CARBON-13 LABELING; HORNER-WADSWORTH-EMMON; ISOTOPICALLY LABELED; KNOEVENAGEL; LABELINGS; NATURAL PRODUCTS; STROBILURINS; WADSWORTH-EMMONS;

CONDENSATION REACTIONS;

1,2 5,5 DICHLOROHEXANOIC ACID C2 13; 1,2 CINNAMIC ACID C2 13; 9,10 DIHYDROISOCOUMARIN C2 13; CARBON 13; CERESIN; CYSTEAMINE DERIVATIVE; HETOCHLORIN; NATURAL PRODUCT; RADIOPHARMACEUTICAL AGENT; STROBILURIN; UNCLASSIFIED DRUG;

ALDOL REACTION; BIOSYNTHESIS; CHIRALITY; CONFERENCE PAPER; DRUG SYNTHESIS; ISOTOPE LABELING; KNOEVENAGEL CONDENSATION; STEREOCHEMISTRY;

EID: 34548187722     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1198     Document Type: Conference Paper

References (12)

1. 13C NMR in metabolic studies. In Modern Methods of Plant Analysis, Vol. 2, Linskens HF, Jackson JF (eds). Springer: Berlin, 1986; 1-42.
2. Aldridge DC, Turner WB. J Chem Soc 1970; 18: 2598.
3. Scott FE, Simpson TJ, Trimble LA, Vederas JC. J Chem Soc Chem Commun 1984; 756.
4. Axford LC, Simpson TJ, Willis CL. Angew Chem Int Ed 2004; 43: 727.
5. Murakami N, Sugimoto M, Kobayashi M. Bioorg Med Chem Lett 2001; 9: 57.
6. Marquez BL, Watts KS, Yokochi A, Roberts MA, Verdier-Pinard P, Jimenez JI, Hamel E, Scheuer PJ, Gerwick WH. J Nat Prod 2002; 65: 866;
7. Suntornchashwej S, Chaichit N, Isobe M, Suwanborirux K. J Nat Prod 2005; 68: 951.
8. Kropp PJ, Crawford SD. J Org Chem 1994; 59: 3102.
9. Takeda T, Sasaki R, Yamauchi S, Fujiwara T. Tetrahedron 1997; 53: 557.
10. Furrow M, Myers A. J Am Chem Soc 2004; 126: 5436.
11. Anke T, Oberwinkler F, Steglich W, Schramm G. J Antibiot 1997; 50: 806.
12. Yue S, Duncan JS, Yamamoto Y, Hutchison CR. J Am Chem Soc 1987; 109: 1253.