Anti-HIV and anti-inflammatory action of iodine-lithium-α-dextrin is accompanied by the improved quality of life in AIDS patients

International Journal of Biotechnology

Volumn 9, Issue 3-4, 2007, Pages 301-317

  Mkhitaryan, Levon M ^a   Davtyan, Tigran K ^a   Gabrielyan, Emil S ^b   Gevorkyan, Levon A ^c  

^a Armenicum Research Centre Yerevan   (Armenia)

^b Armenian Ministry of Health   (Armenia)

^c CJSC Armenicum+   (Armenia)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; IMMUNOLOGY; PATIENT TREATMENT; RNA; VIRUSES;

CLINICAL EFFICACY; MICROGLOBULIN; TUMOUR NECROSIS FACTOR;

CARBOHYDRATES;

ANTIRETROVIRUS AGENT; ARMENICUM; BETA 2 MICROGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IODINE LITHIUM ALPHA DEXTRIN; SOLUBLE INTERLEUKIN 2 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; HUMAN IMMUNODEFICIENCY VIRUS; QUALITY OF LIFE; RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADJUVANT THERAPY; ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FEVER; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; PHLEBITIS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; VIRUS LOAD;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 34548174946     PISSN: 09636048     EISSN: None     Source Type: Journal    
DOI: 10.1504/IJBT.2007.014252     Document Type: Article

References (27)

1. Ilyin, A.I. (2000) 'Armenicum: a new drug with antiviral and antibacterial properties', in E.S. Gabrielyan (Ed). Armenicum: Experimental Studies, Yerevan: Gitutyun, National Academical Science Armenia, pp.7-15.
2. Aleksanyan, Y.T., et al. (2000) 'Bactericidal activity of the Armenicum preparation', in E.S. Gabrielyan (Ed). Armenicum: Experimantal studies. Yerevan: Gitutyun, National Academical Science Armenia, pp.81-87.
3. Allen, T.M., Kelleher, A.D., Zaunders, J. and Walker, B.D. (2002) 'STI and beyond: the prospects of boosting anti-HIV immune responses', Trends Immunology, Vol. 23, pp.456-460.
4. Avetisyan, S.A., Hakobyan, G.S. and Davtyan, T.K. (2006) 'Modulation of endotoxin-induced respiratory splash of granulocytes and monocytes in patients with familial Mediterranean fever by iodine-lithium-α-dextrin and sodium thiosulfate', Patologicheskaia Fiziologiia I Eksperinentarnaia Terapiia, Vol. 1, pp.11-13.
5. + cells in HIV-1-infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads', Journal of Infectious Disease, Vol. 191, pp.1670-1679.
6. Bourinbaiar, A.S. and Abulafia-Lapid, R. (2005) 'Autoimmunity, alloimmunization and immunotherapy of AIDS', Autoimmune Review, Vol. 4, pp.403-409.
7. Broussard, S.R., et al. (2001) 'Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease', Journal of Virology, Vol. 75, pp.2262-2275.
8. Chakrabarti, L.A., et al. (2000) 'Normal T-cell turnover in sooty mangabeys harbouring active simian immunodeficiency virus infection', Journal of Virology, Vol. 74, pp.1209-1223.
9. Connick, E., Lederman, M.M., Kotzin, B.L., Spritzler, J., Kuritzkes, D.R., St Clair, M., Sevin, A.D., Fox, L., Chiozzi, M.H., Leonard, J.M., Rousseau, F., D'Arc Roe, J., Martinez, A., Kessler, H. and Landay, A. (2000) 'Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response', Journal of Infectious Disease, Vol. 181, pp.358-363.
10. Davtyan, T.K., et al. (2001) 'Influence of Armenicum on proliferation of lymphocytes, production of cytokines and soluble markers of immune activation', in E.S.Gabrielyan and L.M. Mkhitaryan (Eds). Armenicum: Experimental and Clinical Studies, Yerevan: Gitutyun, National Academical Science Armenia pp.84-105.
11. Davtyan, T.K., et al. (2004) 'Phagocytosis and oxidative burst down-modulation by potent microbicide lithium-iodophore', Journal of Natural Science, Vol. 2, pp.22-30.
12. Davtyan, T.K., et al. (2006) 'Dexamethasone, colchicine and iodine-lithium-a-dextrin act differentially on the oxidative burst and endotoxin tolerance induction in vitro in patients with Behçet's disease', International Immunopharmacology, Vol. 6, pp.396-407.
13. Gabrielyan, E.S. and Mkhitaryan, L.M. (2001) 'Analogues and prototypes of Armenicum', in (Eds). Armenicum: Experimental and Clinical Studies, Yerevan: Gitutyun, National Academical Science Armenia, pp.84-105.
14. Grossman, Z., et al. (2002) 'CD4 T-cell depletion in HIV infection: are we closer to understanding the cause?' Natural Medicine, Vol. 8, pp.319-323.
15. Hellestein, M.K., et al. (2003) 'Subpopulation of long-lived and short lived T-cells in advanced HIV-1 infection', Journal of Clinical Investigation, Vol. 112, pp.956-966.
16. Ho, D.D. and Huang, Y. (2002) 'The HIV-1 vaccine race', Cell, Vol. 110, pp.135-138.
17. + T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy', Journal of Infectious Disease, Vol. 187, pp.1534-1543.
18. Hunt, P.W., Deeks, S.G., Rodriguez, B., Valdez, H., Shade, S.B., Abrams, D.I., Kitahata, M.M., Krone, M., Neilands, T.B., Brand, R.J., Lederman, M.M. and Martin, J.N. (2003) 'Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy', Aids, Vol. 17, pp.1907-191.
19. Kaufmann, G.R., Furrer, H., Ledergerber, B., Perrin, L., Opravil, M., Vernazza, P., Cavassini, M., Bernasconi, E., Rickenbach, M., Hirschel, B., Battegay, M. (2005) 'Characteristics, determinants, and clinical relevance of CD4 T-cell recovery to <500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy', Clinical Infectious Disease, Vol. 41, pp.361-372.
20. Knipe, D.M., Fields, B.N., Howley, P.M. and Griffin, D.E. (2001) Fields Virology, 4th edition, Vol. 2, Lippinocott, Philadelphia, PA: The Williams & Wilkins Co., pp.1227-1279.
21. + T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency', Journal of Acquired Immune Deficiency Syndrome Human Retrovirology, Vol. 18, pp.332-340.
22. Mascio, D., Dornadula, M.G., Zhang, H., Sullivan, J., Xu, Y., Kulkosky, J., Pomerantz, R.J. and Perelson, A.S. (2003) 'In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per millilitre, with a half-life of 6 mounts', Journal of Virology, Vol. 77. pp.2271-2275.
23. Rey-Cuille, M.A., et al. (1998) 'Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease', Journal of Virology, Vol. 72, pp.3872-3886.
24. + T cells', Natural Medicine, Vol. 9, pp.727-728.
25. Silverstri, G. and Feinberg, M.B. (2003) 'Turnover of lymphocytes and conceptual paradigms in HIV infection', Journal of Clinical Investigation, Vol. 112, pp.821-824.
26. Silvestri, G., et al. (2003) 'Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high level viremia', Immunity, Vol. 18, pp.441-452.
27. Steven, G., Deeks, B. and Walker, D. (2004) 'The immune response to AIDS virus infection: good, bad or both?' Journal of Clinical Investigation, Vol. 113, No. 6, pp.808-810.