Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor

Nature Protocols

Volumn 2, Issue 8, 2007, Pages 1884-1887

  Link, A James ^a,b   Vink, Mandy K S ^a,b,c   Tirrell, David A ^a  

^a California Institute of Technology   (United States)

^b Princeton University   (United States)

^c BioCatalytics Europe GmbH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; AMINO ACID; ESTER DERIVATIVE; FUNCTIONAL GROUP; HOMOSERINE; METHIONINE;

ACIDIFICATION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTALLIZATION; DATA ANALYSIS; ION EXCHANGE CHROMATOGRAPHY; PRECURSOR; PRIORITY JOURNAL; PURIFICATION; REACTION ANALYSIS; SYNTHESIS;

ALANINE; BIOCHEMISTRY; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLIZATION; FORMIC ACID ESTERS; HOMOSERINE;

EID: 34548149792     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2007.269     Document Type: Article

References (2)

1. Mangold, J.B., Mischke, M.R. & Lavelle, J.M. Azidoalanine mutagenicity in Salmonella - effect of homologation and alpha-methyl substitution. Mutat. Res. 216, 27-33 (1989).
2. Link, A.J., Vink, M.K.S. & Tirrell, D.A. Preparation of the functionalizable methionine surrogate azidohomoalanine via copper-catalyzed diazo transfer. Nat. Protoc. 2, 1879-1883 (2007).