Anxiolytic-like effects of obovatol isolated from Magnolia obovata: Involvement of GABA/benzodiazepine receptors complex

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 31, Issue 7, 2007, Pages 1363-1369

  Seo, Jeong Ju ^a   Lee, Seung Ho ^a   Lee, Yong Su ^b   Kwon, Byoung Mok ^c   Ma, Yuan ^a   Hwang, Bang Yeon ^a   Hong, Jin Tae ^a   Oh, Ki Wan ^a  

^a Chungbuk National University   (South Korea)

^b Duksung Women's University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Anxiolytic like effect; Cl channel; GABA benzodiazepine receptor complex; Obovatol; Plus maze

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE RECEPTOR; CHLORIDE; DIAZEPAM; FLUMAZENIL; MAGNOLIA OBOVATA EXTRACT; OBOVATOL; PLANT EXTRACT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CHLORIDE TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; LOCOMOTION; MAGNOLIA OBOVATA; MALE; MAZE TEST; MEDICINAL PLANT; MOUSE; MUSCLE RELAXATION; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NONHUMAN; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTI-INFECTIVE AGENTS; ANXIETY; BIPHENYL COMPOUNDS; CHLORIDES; FLUNITRAZEPAM; GABA MODULATORS; MAGNOLIA; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; MUSCULOSKELETAL EQUILIBRIUM; PHENYL ETHERS; RECEPTORS, GABA-A;

EID: 34548140574     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2007.05.009     Document Type: Article

References (32)

1. Beaubrum G., and Gray G.E. A review of herbal medicines for psychiatric disorder. Psychiatr Serv 51 (2000) 1130-1134
2. A receptors rendered diazepam-insensitive by point-mutation α-subunit. FEBS Lett 431 (1998) 400-404
3. Bhattacharya S.K., and Mitra SK. Anxiolytic activity of Panax ginseng roots: an experimental studies. J Ethnopharmacol 43 (1991) 87-92
4. Budden R., Kuhl U.G., and Bahlsen J. Experiments on the toxic, sedative and muscle relaxant potency of various drug solvents in mice. J Pharmacol Exp Ther 5 (1979) 467-474
5. Cha H.Y., Park J.H., Hong J.T., Yoo H.S., Song S., Hwang B.Y., et al. Anxiolytic-like effects of ginsenosides on the elevated plus-maze model in mice. Biol Pharm Bull 28 (2005) 1621-1625
6. File S.E., and Wardill A.G. Validity of head-dipping as a measurement of exploration in a modified holeboard. Psychopharmacologia 44 (1975) 53-59
7. Friede M., and Freudenstein J. Antidepressant and anxiolytic effect of St. John's wort extract ZE-117. Eur Psychiatr 17 Suppl. 1 (2002) 96
8. 3H]DOPA in various regions of the brain. J Neurochem 13 (1966) 655-669
9. Greenberg P.E., Sisitsky T., Kessler R.C., Finkelstein S.N., Berndt E.R., Davidson J.R.T., et al. The economic burden of anxiety disorders in the 1990s. J Clin Psychiatry 60 (1999) 427-435
10. Guimaraces F.S., Chiartti T.M., Graeff F.G., and Zuardi A.W. Anti-anxiety effect of cannabidiol in the elevated plus-maze. Psychopharmcol 100 (1990) 558-559
11. Hirano T., Wakasugi A., Oohara M., Oka K., and Sashida Y. Suppression of mitogen-induced proliferation of human peripheral blood lymphocytes by plant ligands. Planta Med 57 (1991) 331-334
12. Ito Y., and Kuriyama K. Some properties of solubilized GABA receptors. Brain Res 235 (1982) 351-363
13. Jordan A.D., Kordik C.P., Reitz A.B., and Sanfillipo P.J. Novel anxiolytic agents-1994- to present. Expert Opin Ther Pat 6 (1996) 1047-1060
14. Lo Y.C., Teng C.M., Chen C.F., Chen C.C., and Hong C.Y. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 47 (1994) 549-553
15. Maruyama Y., Kuribara H., Morita M., Yuzurihara M., and Weintraub S. Identification of magnolol and honokiol as anxiolytic agents in extract of Saiboku-to, an oriental herb medicine. J Nat Prod 61 (1998) 135-138
16. Muson P.J., and Rodbard D. Ligand: a versatile computerized approach for the characterization of ligan binding systems. Anal Biochem 107 (1980) 220-239
17. Park J.H., Cha H.Y., Seo J.J., Hong J.T., Han K., and Oh K.W. Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Prog Neuro-Psychopharmacol Biol Psychiatry 29 (2005) 895-900
18. Pellow S., and File S.E. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test foe anxiety in the rat. Pharmacol Biochem Behav 24 (1986) 525-526
19. Quirk G., Armony J.L., and LeDoux J.E. Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdale. Neuron 19 (1997) 613-624
20. Rex A., Morgenstern E., and Fink H. Anxiolytic-like effects of Kava-Kava in the elevated plus maze test-a comparison with diazepam. Prog Neuro-Psychopharmacol Biol Psychiatry 26 (2002) 855-860
21. Rice D.P., and Miller L.S. Health economics and cost implications of anxiety and other mental disorders in the United States. Br J Psychiatry 173 (1998) 4-9
22. Rickels K., and Schweizer E. The clinical presentation of generalized anxiety in primary-care setting: practical concepts of classification and management. J Clin Psychiatry 58 (1997) 4-9
23. Segal D.S., and Kuczenski R. Tyrosine hydroxylase activity: regional and subcellular distribution in brain. Brain Res 68 (1974) 261-266
24. Taketa H., Tsuji M., and Matsumiya T. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur J Pharmacol 350 (1998) 21-29
25. Taukulis H.K., and Goggin C.E. Diazepam-stress interaction in the rat: effects on auto-analgesia and plus-maze model of anxiety. Behav Neural Biol 53 (1990) 205-216
26. 2+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta. Life Sci 47 (1990) 1153-1161
27. Watanabe K., Watanabe H., Goto Y., Yamamoto N., and Yoshizaki M. Studies on the active principles of magnolia bark: centrally acting muscle relaxant activity of magnolol and honokiol. Jpn J Pharmacol 25 (1975) 605-607
28. Watanabe K., Watanabe H., Goto Y., Yamaguchi M., Yamamoto N., and Hagino K. Pharmacological properties of magnolol and honokiol extract from Magnolia officinalis: central depressant effects. Planta Med 49 (1983) 103-108
29. West M.R., and Molloy C. A microplate assay measuring chloride ion channel activity. Anal Biochem 241 (1996) 51-58
30. Wittchen H.U., and Hoyer J. Generalized anxiety disorder: nature and course. J Clin Psychiatry 62 (2001) 15-21
31. Wright I.K., Upton N., and Marsden C.A. Effects of established and putative anxiolytics on extracellular 5-HT and 5-HIAA in the ventral hippocampus of rats during behavior on the elevated X-maze. Psychopharmacol 109 (1992) 338-346
32. Young J., Corpechot C., Perche F., Eychenne B., Huang M., Baulieu E.-E., et al. Neurosteroids in the mouse brain: behavioral and pharmacological effects of 3b-hydroxysteroid dehydrogenase inhibitor. Steroids 61 (1996) 144-149