Structure and function of an essential component of the outer membrane protein assembly machine

Science

Volumn 317, Issue 5840, 2007, Pages 961-964

  Kim, Seokhee ^a   Malinverni, Juliana C ^b   Sliz, Piotr ^c,d   Silhavy, Thomas J ^b   Harrison, Stephen C ^c,d   Kahne, Daniel ^a,c  

^a HARVARD UNIVERSITY   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BETA BARREL PROTEIN; MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN; POLYPEPTIDE; PROTEIN YAET; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

BACTERIUM; CHLOROPLAST; CRYSTAL STRUCTURE; MEMBRANE; MITOCHONDRION; MOLECULAR ANALYSIS; PEPTIDE; PROTEIN; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL MEMBRANE; CELL MEMBRANE; CHLOROPLAST; CRYSTAL STRUCTURE; CYTOPLASM; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; MEMBRANE COMPONENT; MITOCHONDRIAL MEMBRANE; NONHUMAN; POLYPEPTIDE TRANSPORT ASSOCIATED DOMAIN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BACTERIAL OUTER MEMBRANE PROTEINS; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; HYDROPHOBICITY; LIPOPROTEINS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 34548139422     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1143993     Document Type: Article

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29. This work is supported by NIH grants GM66174 (D.K.) and GM34821 (T.J.S.). S.C.H. is a Howard Hughes Medical Institute investigator. Data was collected at beamline ID19 at the Advanced Photon Source, Argonne National laboratory, which is supported by the U.S. Department of Energy, under contract no. W-31-109-ENG-38. We thank J. J. Miranda and R. Meijers for technical support. Coordinates and structure factors have been deposited in the Protein Data Bank with the accession codes 2QCZ and 2QDF.