Carisoprodol intoxications: A retrospective study of forensic autopsy material from 1992-2003

International Journal of Legal Medicine

Volumn 121, Issue 5, 2007, Pages 403-409

  Høiseth, Gudrun ^a   Bramness, Jørgen G ^a   Christophersen, Asbjørg S ^a   Mørland, Jørg ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

Blood concentration; Carisoprodol; Intoxication; Meprobamate; Postmortem

Indexed keywords

CARISOPRODOL;

ADULT; ARTICLE; AUTOPSY; BLOOD ANALYSIS; CAUSE OF DEATH; CONTROLLED STUDY; CORRELATION ANALYSIS; FATALITY; FEMALE; FORENSIC MEDICINE; HUMAN; INTOXICATION; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; CARISOPRODOL; FEMALE; FORENSIC TOXICOLOGY; HUMANS; MALE; MEPROBAMATE; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; POISONING; PRESCRIPTIONS, DRUG; RETROSPECTIVE STUDIES; SUBSTANCE ABUSE DETECTION; SUICIDE;

EID: 34548133099     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-006-0139-1     Document Type: Article

References (43)

1. Dalen P, Alvan G, Wakelkamp M, Olsen H (1996) Formation of meprobamate from carisoprodol is catalysed by CYP2C19. Pharmacogenetics 6:387-394
2. van Tulder MW, Touray T, Furlan AD, Solway S, Bouter LM (2003) Muscle relaxants for nonspecific low back pain: a systematic review within the framework of the cochrane collaboration. Spine 28:1978-1992
3. Hindle TH III (1972) Comparison of carisoprodol, butabarbital, and placebo in treatment of the low back syndrome. Calif Med 117:7-11
4. Boyles W, Glassmann J, Soyka J (1983) Management of acute muskuloskeletal conditions: thoracolumbar strain and pain. A double-blind evaluation comparing the efficacy and safety of carisoprodol with diazepam. Today's Ther Trends 1:1-16
5. Rollings H, Glassmann J, Soyka J (1982) Management of acute muskuloskeletal conditions-thoracolumbar strain and sprain: a double-blind evaluation comparing the efficacy and safety of carisoprodol with cyclobenzadrine hydrochloride. Curr Ther Res 34:917-928
6. Boothby L, Doering P, Hatton R (2003) Carisoprodol: a marginally effective skeletal muscle relaxant with serious abuse potential. Hosp Pharm 38:337-345
7. Wyller TB, Korsmo G, Gadeholt G (1991) Dependence on carisoprodol (Somadril)? A prospective withdrawal study among prisoners [Avhengig av karisoprodol (Somadril)? En prospektiv seponeringsundersøkelse blant fengselsinnsatte]. Tidsskr Nor Laegeforen 111:193-195
8. Reeves RR, Carter OS, Pinkofsky HB, Struve FA, Bennett DM (1999) Carisoprodol (soma): abuse potential and physician unawareness. J Addict Dis 18:51-56
9. Bailey DN, Briggs JR (2002) Carisoprodol: an unrecognized drug of abuse. Am J Clin Pathol 117:396-400
10. Sikdar S, Basu D, Malhotra AK, Varma VK, Mattoo SK (1993) Carisoprodol abuse: a report from India. Acta Psychiatr Scand 88:302-303
11. Bramness JG, Morland J, Sorlid HK, Rudberg N, Jacobsen D (2005) Carisoprodol intoxications and serotonergic features. Clin Toxicol 43:39-45
12. Siddiqi M, Jennings CA (2004) A near-fatal overdose of carisoprodol (SOMA): case report. J Toxicol Clin Toxicol 42:239-240
13. Roth BA, Vinson DR, Kim S (1998) Carisoprodol-induced myoclonic encephalopathy. J Toxicol Clin Toxicol 36:609-612
14. Roberge RJ, Lin E, Krenzelok EP (2000) Flumazenil reversal of carisoprodol (Soma) intoxication. J Emerg Med 18:61-64
15. Roache JD, Griffiths RR (1987) Lorazepam and meprobamate dose effects in humans: behavioral effects and abuse liability. J Pharmacol Exp Ther 243:978-988
16. Winek CL, Wahba WW, Winek CL Jr, Balzer TW (2001) Drug and chemical blood-level data 2001. Forensic Sci Int 122:107-123
17. Druid H, Holmgren P (1997) A compilation of fatal and control concentrations of drugs in postmortem femoral blood. J Forensic Sci 42:79-87
18. Chung H, Park M, Hahn E, Choi H, Choi H, Lim M (2004) Recent trends of drug abuse and drug-associated deaths in Korea. Ann N Y Acad Sci 1025:458-464
19. Backer RC, Zumwalt R, McFeeley P, Veasey S, Wohlenberg N (1990) Carisoprodol concentrations from different anatomical sites: three overdose cases. J Anal Toxicol 14:332-334
20. Adams HR, Kerzee T, Morehead CD (1975) Carisoprodol-related death in a child. J Forensic Sci 20:200-202
21. Davis GG, Alexander CB (1998) A review of carisoprodol deaths in Jefferson County, Alabama. South Med J 91:726-730
22. Ronning M (2001) Drug consumption in Norway 1996-2000 [Legemiddelforbruket i Norge 1996-2000], Norwegian Medicinal Depot, Oslo
23. Ronning M, Sanner T, Boe GH, Litleskare I, Strøm H, Granum T (2005) Drug consumption in Norway 2000-2004 [Legemiddelforbruket i Norge 2000-2004], Norwegian Institute of Public Health, Oslo
24. Oydvin K, Ronning M, Sakshaug S, Blix H, Ullerud T (1997) Drug consumption in Norway 1992-1996 [Legemiddelforbruket i Norge 1992-1996], Norsk Medisinaldepot AS, Oslo
25. TIAFT (2006) http://www.tiaft.org/tmembers/ttvidx.html. Cited 7 Feb 2006
26. Micomedex (2006) http://www.thomsonhc.com/hcs/librarian/PFPUI/ Tq4CzCw1heeLZm. Micromedex. Cited 7 Feb 2006
27. Reith DM, Fountain J, McDowell R, Tilyard M (2003) Comparison of the fatal toxicity index of zopiclone with benzodiazepines. J Toxicol Clin Toxicol 41:975-980
28. Hilberg T, Rogde S, Morland J (1999) Postmortem drug redistribution-human cases related to results in experimental animals. J Forensic Sci 44:3-9
29. Hilberg T, Morland J, Bjorneboe A (1994) Postmortem release of amitriptyline from the lungs; a mechanism of postmortem drug redistribution. Forensic Sci Int 64:47-55
30. Pelissier-Alicot AL, Gaulier JM, Dupuis C et al (2006) Post-mortem redistribution of three beta-blockers in the rabbit. Int J Legal Med 120:226-232
31. Schulz M, Schmoldt A (1997) Therapeutic and toxic blood concentrations of more than 500 drugs. Pharmazie 52:895-911
32. Olsen H, Koppang E, Alvan G, Morland J (1994) Carisoprodol elimination in humans. Ther Drug Monit 16:337-340
33. Bramness JG, Skurtveit S, Gulliksen M, Breilid H, Steen VM, Morland J (2005) The CYP2C19 genotype and the use of oral contraceptives influence the pharmacokinetics of carisoprodol in healthy human subjects. Eur J Clin Pharmacol 61:499-506
34. Woods JH, Katz JL, Winger G (1992) Benzodiazepines: use, abuse, and consequences. Pharmacol Rev 44:151-347
35. Steentoft A, Teige B, Ceder G et al (2001) Fatal poisoning in drug addicts in the Nordic countries. Forensic Sci Int 123:63-69
36. Jonsson A, Holmgren P, Ahlner J (2004) Fatal intoxications in a Swedish forensic autopsy material during 1992-2002. Forensic Sci Int 143:53-59
37. Morland J (2000) Driving under the influence of medication and various substances other than alcohol [Kjøring under påvirkning av medikamenter og andre rusmidler enn alkohol]. Tidsskr Nor Laegeforen 120:2148-2150
38. Meel BL (2004) Incidence and patterns of violent and/or traumatic deaths between 1993 and 1999 in the Transkei region of South Africa. J Trauma 57:125-129
39. Qin P, Agerbo E, Westergard-Nielsen N, Eriksson T, Mortensen PB (2000) Gender differences in risk factors for suicide in Denmark. Br J Psychiatry 177:546-550
40. Demetriades D, Gkiokas G, Velmahos GC, Brown C, Murray J, Noguchi T (2004) Alcohol and illicit drugs in traumatic deaths: prevalence and association with type and severity of injuries. J Am Coll Surg 199:687-692
41. Bramness JG, Skurtveit S, Grung M, Morland J (2000) Centrally acting muscle relaxants and traffic hazards [Sentralt virkende muskelrelakserende midler i trafikken]. Tidsskr Nor Laegeforen 120:1966-1969
42. Substance Abuse and Mental Health Service Administration (2003) Emergency department trends from the drug abuse warning network, final estimates 1995-2002. DAWN Series D-24, Rockville, MD
43. Koski A, Vuori E, Ojanpera I (2005) Newer antidepressants: evaluation of fatal toxicity index and interaction with alcohol based on Finnish postmortem data. Int J Legal Med 119:344-348