Beyond Sports-Doping Headlines: The Science of Laboratory Tests for Performance-Enhancing Drugs

Pediatric Clinics of North America

Volumn 54, Issue 4, 2007, Pages 713-733

  Hatton, Caroline K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANABOLIC AGENT; ANTIESTROGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CANNABINOID; CANNABIS; CENTRAL STIMULANT AGENT; DIURETIC AGENT; GLUCOCORTICOID; HORMONE; ILLICIT DRUG; NARCOTIC AGENT; RECOMBINANT ERYTHROPOIETIN;

ANALYTIC METHOD; ATHLETE; BLOOD EXAMINATION; DOPING; DRUG ABUSE; DRUG IDENTIFICATION; DRUG RESEARCH; DRUG SCREENING; GAS CHROMATOGRAPHY; HUMAN; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXYGEN TRANSPORT; REVIEW; SPORT; URINALYSIS;

ADOLESCENT; DOPING IN SPORTS; HUMANS; SPORTS MEDICINE; SUBSTANCE ABUSE DETECTION;

EID: 34548126978     PISSN: 00313955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcl.2007.04.008     Document Type: Review

References (27)

1. The World Anti-Doping Code. The 2007 prohibited list international standard. Available at: http://www.wada-ama.org/rtecontent/document/2007_List_En.pdf. Accessed February 13, 2007.
2. WADA technical document TD2004MRPL. Minimum required performance limits for detection of prohibited substances. Available at: http://www.wada-ama.org/rtecontent/document/perf_limits_2.pdf. Accessed February 14, 2007.
3. NCAA banned-drug classes 2006-2007. Available at: http://www1.ncaa.org/membership/ed_outreach/health-safety/drug_testing/banned_drug_classes.pdf. Accessed February 13, 2007.
4. The World Anti-Doping Code. International standard for laboratories version 4.0. Available at: http://www.wada-ama.org/rtecontent/document/lab_aug_04.pdf. Accessed February 14, 2007.
5. Tsivou M., Kioukia-Fougia N., Lyris E., et al. An overview of the doping control analysis during the Olympic Games of 2004 in Athens, Greece. Anal Chim Acta 555 (2006) 1-13
6. UCI Cycling Regulations. Part 13 sporting safety and conditions. Available at: http://www.uci.ch/imgArchive/Rules/13con-E.pdf. Accessed February 15, 2007.
7. Cheating on a drug test. Available at: http://www.drugfreesportcom/insight.asp?VolID=31&;TopicID=7. Accessed February 14, 2007.
8. Trout G.J., and Kazlauskas R. Sports drugs testing-an analyst's perspective. Chem Soc Rev 33 (2004) 1-13
9. Sekera M.H., Ahrens B., Chang Y.C., et al. Another designer steroid: discovery, synthesis, and detection of 'madol' in urine. Rapid Commun Mass Spectrom 19 (2005) 781-784
10. Aguilera R., Chapman T.E., Starcevic B., et al. Performance characteristics of a carbon isotope ratio method for detecting doping with testosterone based on urine diols: controls and athletes with elevated testosterone/epitestosterone ratios. Clin Chem 47 (2001) 292-300
11. WADA Technical Document TD2004EAAS Version 1.0. Reporting and evaluation guidance for testosterone, epitestosterone, T/E ratio and other endogenous steroids. Available at: http://www.wada-ama.org/rtecontent/document/end_steroids_aug_04.pdf. Accessed February 13, 2007.
12. Lasne F., Martin L., Crepin N., et al. Detection of isoelectric profiles of erythropoietin in urine: differentiation of natural and administered recombinant hormones. Anal Biochem 311 (2002) 119-126
13. Catlin D.H., Breidbach A., Elliott S., et al. Comparison of the isoelectric focusing patterns of darbepoetin alfa, recombinant human erythropoietin, and endogenous erythropoietin from human urine. Clin Chem 48 (2002) 2057-2059
14. WADA Technical Document TD2004EPO Version 1.0. Harmonization of the method for the identification of epoetin alfa and beta (EPO) and darbepoetin alfa (NESP) by IEF-double blotting and chemiluminescent detection. Available at: http://www.wada-ama.org/rtecontent/document/td2004epo_en.pdf. Accessed February 13, 2007.
15. Parisotto R., Gore C.J., Emslie K.R., et al. A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin in athletes. Haematologica 85 (2000) 564-572
16. Wallace J.D., Cuneo R.C., Bidlingmaier M., et al. Changes in non-22-kilodalton (kDa) isoforms of growth hormone (GH) after administration of 22-kDa recombinant human GH in trained adult males. J Clin Endocrinol Metab 86 (2001) 1731-1737
17. Bowers L. Lessons learned from recent doping investigations and athlete cases. In: Doping: the World Anti-Doping Program and the role of medical care providers in doping and anti-doping efforts. Workshop #14, 20 February 2007. Presented at the 59th Annual Meeting of the American Academy of Forensic Scientists. San Antonio (TX).
18. Testimony of Kelli White, U.S. Olympian, former steroid user, to the U.S. Senate. Available at: http://commerce.senate.gov/hearings/testimony.cfm?id=1511&;wit_id=4276. Accessed February 16, 2007.
19. Catlin D.H., Ahrens B.D., and Kucherova Y. Detection of norbolethone, an anabolic steroid never marketed, in athletes' urine. Rapid Commun Mass Spectrom 16 (2002) 1273-1275
20. Catlin D.H., Sekera M.H., Ahrens B., et al. Tetrahydrogestrinone: discovery, synthesis, and detection in urine. Rapid Commun Mass Spectrom 18 (2004) 1245-1249
21. Can you win without supplements?. Available at: http://www.drugfreesport.com. Accessed February 14, 2007.
22. USADA protocol for Olympic movement testing. Available at: http://www.usantidoping.org/files/active/what/protocol.pdf. Accessed February 14, 2007.
23. NCAA Drug-Testing Program 2006-2007. Available at: http://www.ncaa.org/library/sports_sciences/drug_testing_program/2006-07/2006-07_drug_testing_program.pdf. Accessed February 14, 2007.
24. WADA program statistics. Available at: http://www.wada-ama.org/en/dynamic.ch2?pageCategory.id=328. Accessed February 14, 2007.
25. USADA testing statistics. Available at: http://www.usantidoping.org/what/stats/. Accessed January 26, 2007.
26. NCAA drug-testing program overview and results archive. Available at: http://www.ncaa.org/sports_sciences/drugtesting/drug_testing_results_archive.html. Accessed February 14, 2007.
27. Alexander B. The awful truth about drugs in sports. Outside July 2005;100-108. Available at: http://outside.away.com/outside/features/200507/drugs-in-sports-1.html. Accessed February 16, 2007.