Administration of acepromazine maleate to 31 dogs with a history of seizures

Journal of Veterinary Emergency and Critical Care

Volumn 17, Issue 3, 2007, Pages 262-267

  McConnell, Janice ^a,b   Kirby, Rebecca ^a   Rudloff, Elke ^a  

^a Animal Emergency Center   (United States)

^b Animal Emergency Center   (United States)

Author keywords

Acepromazine; Dog; Phenothiazine; Seizure

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 34548118726     PISSN: 14793261     EISSN: 14764431     Source Type: Journal    
DOI: 10.1111/j.1476-4431.2007.00231.x     Document Type: Article

References (39)

1. Thurmon JC, Tranquilli WJ, Benson GJ. Preanesthetics and anesthetic adjunct, In : Thurmon JC, Tranquilli WJ, Benson GJ. eds. Lumb and Jones Veterinary Anesthesia, 3rd edn. Baltimore, MD : Williams & Wilkins 1996, pp. 185 186.
2. Muir WW, Hubbell JAE, Skarda RT, et al. Drugs and preanesthetic medication, In : Muir WW, Hubbell JAE, Skarda RT, Bednarski RM. eds. Handbook of Veterinary Anesthesia, 3rd edn. St. Louis: Mosby 2000, pp. 23 26.
3. Schwartz-Porsche D. Management of refractory seizures, In : Kirk R, Bonagura J. eds. Current Veterinary Therapy XI. Philadelphia : WB Saunders 1992, pp. 986 991.
4. Lapin IP, Ryzov IV. Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice. J Neural Transm 1990 82 : 55 65.
5. Torta R, Monaco F. Atypical antipsychotics and serotoninergic antidepressants in patients with epilepsy: pharmacodynamic considerations. Epilepsia 2002 43 (Suppl. 2) : 8 13.
6. - current in rat dorsal root ganglion neurons: differences between some neuroleptics. Br J Pharmacol 2002 135 : 1547 1555.
7. Ebert U, Löscher W. Monoamine interactions in animal models of epilepsy, In : Palomo T, Beninger RJ, Archer T. eds. Interactive Monoaminergic Disorders. Madrid : Editorial Sintesis 1998, pp. 555 572.
8. 2-adrenergic agonists, and related agents, In : Adams HR. ed. Veterinary Pharmacology and Therapeutics, 8th edn. Ames: Iowa State University Press 2001, pp. 299 313.
9. Green AR. Repeated chlorpromazine administration increases a behavioural response of rats to 5-hydroxytryptamine receptor stimulation. Br J Pharmacol 1977 59 : 367 371.
10. Popovic NA, Mullane JF, Yhap EO. Effects of acetylpromazine maleate on certain cardiorespiratory responses in dogs. Am J Vet Res 1972 33 : 1819 1824.
11. Stepien RL, Bonagura JD, Bednarski RM, et al. Cardiorespiratory effects of acepromazine maleate and buprenorphine hydrochloride in clinically normal dogs. Am J Vet Res 1995 56 : 402.
12. Chai CY, Fann YD, Lin MT. Hypothermic action of chlorpromazine in monkeys. Br J Pharmacol 1976 57 : 43 49.
13. Kortelainen ML, Lapinlampi T, Hirvonen J. Chlorpromazine-induced alterations in hypothalamic amine metabolism and stress responses in severe cold. Z Rechtsmed 1989 102 : 377 390.
14. Neve KA, Henningsen RA, Bunzow JR, et al. Functional characterization of a rat dopamine D-2 receptor cDNA expressed in a mammalian cell line. Mol Pharmacol 1989 36 : 446 451.
15. Kanterman RY, Mahan LC, Briley EM, et al. Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells. Mol Pharmacol 1991 39 : 364 369.
16. 2+ concentration decrease in GH4C1 cells. J Biol Chem 1990 265 : 10320 10326.
17. Albert PR, Neve KA, Bunzow JR, et al. Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion. J Biol Chem 1990 265 : 2098 2104.
18. Liu L, Shen RY, Kapatos G, et al. Dopamine neuron membrane physiology: characterization of the transient outward current (IA) and demonstration of a common signal transduction pathway for IA and IK. Synapse 1994 17 : 230 240.
19. Anton-Stephens D. Preliminary observations on the psychiatric use of chlorpromazine. J Ment Sci 1953 100 : 543 547.
20. Itil TM, Soldatos C. Epileptogenic side effects of psychotropic drugs. J Am Med Assoc 1980 244 : 1460 1463.
21. Itil TM. Psychotropic drugs and the human EEG, In : Neidermeyer E, Lopes da Silva F. eds. Electroencephalography: Basic Principles, Clinical Applications and Related Fields. Baltimore : Urban & Schwarzenberg 1982, pp. 499 513.
22. Aguglia U, Gambardella A, Le Piane E, et al. Chlorpromazine versus sleep deprivation in activation of EEG in adult-onset partial epilepsy. J Neur 1994 241 (10) : 605 610.
23. Logothetis J. Spontaneous epileptic seizures and electroencephalographic changes in the course of phenothiazine therapy. Neurology 1967 17 : 869 877.
24. Kitano Y, Usui C, Takasuna K, et al. Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice. J Pharm Tox Methods 1996 35 : 25 29.
25. Bureau Y, Persinger MA. Cholinergic rebounds after chlorpromazine exacerbates lithium muscarinic-induced limbic seizures in rats: implications for psychiatric treatment. Psych Reports 1991 69 : 171 176.
26. Muir WW. Drugs used to treat pain, In : Gaynor JS, Muir WW. eds. Handbook of Veterinary Pain Management. St. Louis : Mosby Inc 2002, p. 162.
27. Plumb DC. Veterinary Drug Handbook, 4th edn. Ames : Iowa State Press 2002, p. 4.
28. Ballard S, Shults T, Kownacki AA, et al. The pharmacokinetics, pharmacological responses and behavioral effects of acepromazine in the horse. J Vet Pharmacol Ther 1982 5 : 21 31.
29. Pugh DM. Acepromazine in veterinary use. Vet Rec 1964 76 : 439.
30. Aguglia U, Gambardella A, Le Piane E, et al. Chlorpromazine versus sleep deprivation in activation of EEG in adult-onset partial epilepsy. J Neur 1994 241 (10) : 605 610.
31. Loga S, Curry S, Lader M. Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man. Br J Clin Pharmacol 1975 2 : 197 208.
32. Spina E, Perucca E. Clinical significance of pharmacokinetic interactions between antiseizure and psychotropic drugs. Epilepsia 2002 43 (Suppl. 2) : 37 44.
33. Pisani F, Oteri G, Costa C, et al. Effects of psychotropic drugs on seizure threshold. Drug Safety 2002 25 (2) : 91 110.
34. Ebert U. Basic mechanisms of psychotropic drugs. Epilepsia 2002 43 (Suppl. 2) : 2 7.
35. Torta R, Monaco F. Atypical antipsychotics and serotoninergic antidepressants in patients with epilepsy: pharmacodynamic considerations. Epilepsia 2002 43 (Suppl. 2) : 8 13.
36. Koch-Stoecker S. Antipsychotic drugs and epilepsy: indications and treatment guidelines. Epilepsia 2002 43 (Suppl. 2) : 19 24.
37. Bateman SW. Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995). J Am Vet Med Assoc 1999 215 (10) : 1463 1468.
38. Alldredge BK. Seizure risk associated with psychotropic drugs: clinical and pharmacokinetic considerations. Neurology 1999 53 (Suppl. 2) : S68 S75.
39. Toone BK, Fenton GW. Epileptic seizures induced by psychotropic drugs. Psych Med 1977 7 : 265 270.