Does metoprolol inhibit the cortical spreading depression? Acute effects of systematic metropol on CSD in rats

Cephalalgia

Volumn 27, Issue 9, 2007, Pages 1010-1013

  Alemdar, M ^a   Akman, O ^a   Selekler, H M ^a   Komsuoglu S S ^a   Ates N ^a  

^a KOCAELI UNIVERSITY   (Turkey)

Author keywords

Cortical spreading depression; Metoprolol; Migraine

Indexed keywords

METOPROLOL TARTRATE; POTASSIUM CHLORIDE; SILVER CHLORIDE; THIOPENTAL;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; DIRECT CURRENT; DURA MATER; ELECTRODE; NONHUMAN; RAT; SPREADING CORTICAL DEPRESSION;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; MALE; METOPROLOL; NEURAL INHIBITION; RATS; RATS, WISTAR; SPREADING CORTICAL DEPRESSION; SYMPATHOLYTICS;

EID: 34548104449     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1111/j.1468-2982.2007.01390.x     Document Type: Article

References (12)

1. Bolay H, Reuter U, Dunn A, Huang Z, Boas D, Moskowitz A. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature Med 2002 8: 136 42.
2. Dalkara T, Zervas NT, Moskowitz MA. From spreading depression to the trigeminovascular system. Neurol Sci 2006 27 (Suppl. 2 S86 90.
3. Akerman S, Goadsby PJ. Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura. Neuroreport 2005 16: 1383 7.
4. van der Hel WS, van den Bergh WM, Nicolay K, Tulleken KA, Dijkhuizen RM. Suppression of cortical spreading depressions after magnesium treatment in the rat. Neuroreport 1998 9: 2179 82.
5. Anderson PG, Dahl S, Hansen JH, Hansen PE, Hedman C, Nygaard Kristensen T et al. Prophylactic treatment of classical and common migraine with metoprolol - a comparison with placebo. Cephalalgia 1983 3: 207 12.
6. Kangasniemi P, Hedman C. Metoprolol and propranolol in the prophylactic treatment of classical and common migraine. A double-blind study. Cephalalgia 1984 4: 91 6.
7. Nakazono T, Murakami T, Sakai S, Higashi Y, Yata N. Brain and cerebrospinal fluid distributions of metoprolol in rats. J Pharmacobiodyn 1992 15: 295 302.
8. Kaube H, Goadsby PJ. Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat. Eur Neurol 1994 34: 30 5.
9. Junker V, Becker A, Huhne R, Zembatov M, Ravati A, Culmsee C et al. Stimulation of beta-adrenoceptors activates astrocytes and provides neuroprotection. Eur J Pharmacol 2002 446: 25 36.
10. Omerovic E, Bollano E, Mobini R, Madhu B, Kujacic V, Soussi B et al. Selective beta (1)-blockade improves cardiac bioenergetics and function and decreases neuroendocrine activation in rats during early postinfarct remodeling. Biochem Biophys Res Commun 2001 281: 491 8.
11. Shields KG, Goadsby PJ. Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine? Brain 2005 128: 86 97.
12. Ayata C, Jin H, Kudo C, Dalkara T, Moskowitz MA. Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 2006 59: 652 61.