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Volumn 7, Issue 4, 2007, Pages 426-433

B cell modulation in rheumatology

Author keywords

[No Author keywords available]

Indexed keywords

ABETIMUS; APRIL PROTEIN; ATACICEPT; AUTOANTIBODY; B CELL ACTIVATING FACTOR; BAFF RECEPTOR 3; BELIMUMAB; CD19 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; CD79A ANTIGEN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; EPRATUZUMAB; FC RECEPTOR; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; INTERLEUKIN 6 ANTIBODY; LPJ 394; LYMPHO STAT B; METHOTREXATE; MONOCLONAL ANTIBODY; OCRELIZUMAB; OFATUMUMAB; RECEPTOR PROTEIN; RITUXIMAB; STAPHYLOCOCCUS PROTEIN A; TACI RECEPTOR; TRU 015; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 34548098116     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2007.05.006     Document Type: Review
Times cited : (5)

References (55)
  • 1
    • 0142218537 scopus 로고    scopus 로고
    • B cell therapy for rheumatoid arthritis: the rituximab (anti-CD20) experience
    • Shaw T., Quan J., and Totoritis M.C. B cell therapy for rheumatoid arthritis: the rituximab (anti-CD20) experience. Ann Rheum Dis 62 Suppl 2 (2003) ii55-ii59
    • (2003) Ann Rheum Dis , vol.62 SUPPL. 2
    • Shaw, T.1    Quan, J.2    Totoritis, M.C.3
  • 2
    • 33646198040 scopus 로고    scopus 로고
    • B cell immunobiology in disease: evolving concepts from the clinic
    • Martin F., and Chan A.C. B cell immunobiology in disease: evolving concepts from the clinic. Annu Rev Immunol 24 (2006) 467-496
    • (2006) Annu Rev Immunol , vol.24 , pp. 467-496
    • Martin, F.1    Chan, A.C.2
  • 3
    • 33746974761 scopus 로고    scopus 로고
    • Therapeutic B cell depletion and regeneration in rheumatoid arthritis: emerging patterns and paradigms
    • Silverman G.J. Therapeutic B cell depletion and regeneration in rheumatoid arthritis: emerging patterns and paradigms. Arthritis Rheum 54 (2006) 2356-2367
    • (2006) Arthritis Rheum , vol.54 , pp. 2356-2367
    • Silverman, G.J.1
  • 4
    • 33344458515 scopus 로고    scopus 로고
    • Abetimus sodium (riquent) for the prevention of nephritic flares in patients with systemic lupus erythematosus
    • x
    • Furie R. Abetimus sodium (riquent) for the prevention of nephritic flares in patients with systemic lupus erythematosus. Rheum Dis Clin North Am 32 (2006) 149-156 x
    • (2006) Rheum Dis Clin North Am , vol.32 , pp. 149-156
    • Furie, R.1
  • 6
    • 32044471639 scopus 로고    scopus 로고
    • Temporal and dose-dependent relationships between in vivo B cell receptor-targeted proliferation and deletion-induced by a microbial B cell toxin
    • Goodyear C.S., Sugiyama F., and Silverman G.J. Temporal and dose-dependent relationships between in vivo B cell receptor-targeted proliferation and deletion-induced by a microbial B cell toxin. J Immunol 176 (2006) 2262-2271
    • (2006) J Immunol , vol.176 , pp. 2262-2271
    • Goodyear, C.S.1    Sugiyama, F.2    Silverman, G.J.3
  • 7
    • 13144290160 scopus 로고    scopus 로고
    • On the mechanism of staphylococcal protein A immunomodulation
    • Silverman G.J., Goodyear C.S., and Siegel D.L. On the mechanism of staphylococcal protein A immunomodulation. Transfusion 45 (2005) 274-280
    • (2005) Transfusion , vol.45 , pp. 274-280
    • Silverman, G.J.1    Goodyear, C.S.2    Siegel, D.L.3
  • 8
    • 33847382765 scopus 로고    scopus 로고
    • Cutting edge: bim is required for superantigen-mediated B cell death
    • Goodyear C.S., Corr M., Sugiyama F., Boyle D.L., and Silverman G.J. Cutting edge: bim is required for superantigen-mediated B cell death. J Immunol 178 (2007) 2636-2640
    • (2007) J Immunol , vol.178 , pp. 2636-2640
    • Goodyear, C.S.1    Corr, M.2    Sugiyama, F.3    Boyle, D.L.4    Silverman, G.J.5
  • 9
    • 16844371598 scopus 로고    scopus 로고
    • Effect of the B cell superantigen protein A from S. aureus on the early lupus disease of (NZBxNZW) F1 mice
    • Viau M., and Zouali M. Effect of the B cell superantigen protein A from S. aureus on the early lupus disease of (NZBxNZW) F1 mice. Mol Immunol 42 (2005) 849-855
    • (2005) Mol Immunol , vol.42 , pp. 849-855
    • Viau, M.1    Zouali, M.2
  • 10
    • 33745698861 scopus 로고    scopus 로고
    • Confounding B-cell defences: lessons from a staphylococcal superantigen
    • Silverman G.J., and Goodyear C.S. Confounding B-cell defences: lessons from a staphylococcal superantigen. Nat Rev Immunol 6 (2006) 465-475
    • (2006) Nat Rev Immunol , vol.6 , pp. 465-475
    • Silverman, G.J.1    Goodyear, C.S.2
  • 12
    • 7244248664 scopus 로고    scopus 로고
    • From the bench to the bedside: ways to improve rituximab efficacy
    • Cartron G., Watier H., Golay J., and Solal-Celigny P. From the bench to the bedside: ways to improve rituximab efficacy. Blood 104 (2004) 2635-2642
    • (2004) Blood , vol.104 , pp. 2635-2642
    • Cartron, G.1    Watier, H.2    Golay, J.3    Solal-Celigny, P.4
  • 13
    • 19944427673 scopus 로고    scopus 로고
    • Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy
    • Gong Q., Ou Q., Ye S., Lee W.P., Cornelius J., Diehl L., Lin W.Y., Hu Z., Lu Y., Chen Y., et al. Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol 174 (2005) 817-826
    • (2005) J Immunol , vol.174 , pp. 817-826
    • Gong, Q.1    Ou, Q.2    Ye, S.3    Lee, W.P.4    Cornelius, J.5    Diehl, L.6    Lin, W.Y.7    Hu, Z.8    Lu, Y.9    Chen, Y.10
  • 14
    • 15444368773 scopus 로고    scopus 로고
    • The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice
    • Hamaguchi Y., Uchida J., Cain D.W., Venturi G.M., Poe J.C., Haas K.M., and Tedder T.F. The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. J Immunol 174 (2005) 4389-4399
    • (2005) J Immunol , vol.174 , pp. 4389-4399
    • Hamaguchi, Y.1    Uchida, J.2    Cain, D.W.3    Venturi, G.M.4    Poe, J.C.5    Haas, K.M.6    Tedder, T.F.7
  • 15
    • 3042592452 scopus 로고    scopus 로고
    • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
    • Uchida J., Hamaguchi Y., Oliver J.A., Ravetch J.V., Poe J.C., Haas K.M., and Tedder T.F. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med 199 (2004) 1659-1669
    • (2004) J Exp Med , vol.199 , pp. 1659-1669
    • Uchida, J.1    Hamaguchi, Y.2    Oliver, J.A.3    Ravetch, J.V.4    Poe, J.C.5    Haas, K.M.6    Tedder, T.F.7
  • 17
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at 24 weeks
    • REFLEX Trial Group
    • Cohen S.B., Emery P., Greenwald M.W., Dougados M., Furie R.A., Genovese M.C., Keystone E.C., Loveless J.E., Burmester G.R., Cravets M.W., et al., REFLEX Trial Group. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at 24 weeks. Arthritis Rheum 54 (2006) 2793-2806
    • (2006) Arthritis Rheum , vol.54 , pp. 2793-2806
    • Cohen, S.B.1    Emery, P.2    Greenwald, M.W.3    Dougados, M.4    Furie, R.A.5    Genovese, M.C.6    Keystone, E.C.7    Loveless, J.E.8    Burmester, G.R.9    Cravets, M.W.10
  • 19
    • 33750315937 scopus 로고    scopus 로고
    • Targeting of B cells in SLE: rationale and therapeutic opportunities
    • Silverman G.J. Targeting of B cells in SLE: rationale and therapeutic opportunities. Bull NYU Hosp Jt Dis 64 (2006) 51-56
    • (2006) Bull NYU Hosp Jt Dis , vol.64 , pp. 51-56
    • Silverman, G.J.1
  • 20
    • 2942737087 scopus 로고    scopus 로고
    • Randomized controlled trials in systemic lupus erythematosus: what has been done and what do we need to do?
    • Schiffenbauer J., and Simon L.S. Randomized controlled trials in systemic lupus erythematosus: what has been done and what do we need to do?. Lupus 13 (2004) 398-405
    • (2004) Lupus , vol.13 , pp. 398-405
    • Schiffenbauer, J.1    Simon, L.S.2
  • 23
    • 13444252282 scopus 로고    scopus 로고
    • Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial
    • Sfikakis P.P., Boletis J.N., Lionaki S., Vigklis V., Fragiadaki K.G., Iniotaki A., and Moutsopoulos H.M. Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial. Arthritis Rheum 52 (2005) 501-513
    • (2005) Arthritis Rheum , vol.52 , pp. 501-513
    • Sfikakis, P.P.1    Boletis, J.N.2    Lionaki, S.3    Vigklis, V.4    Fragiadaki, K.G.5    Iniotaki, A.6    Moutsopoulos, H.M.7
  • 24
    • 34548151122 scopus 로고    scopus 로고
    • Ng KP, Cambridge G, Leandro MJ, Edwards JC, Ehrenstein M, Isenberg DA. B cell depletion therapy in systemic lupus erythematosus: long term follow up and predictors of response. Ann Rheum Dis 2007, April 5 [Epub ahead of print].
  • 25
    • 19544364494 scopus 로고    scopus 로고
    • Changes in salivary gland immunohistology and function after rituximab monotherapy in a patient with Sjogren's syndrome and associated MALT lymphoma
    • Pijpe J., van Imhoff G.W., Vissink A., van der Wal J.E., Kluin P.M., Spijkervet F.K., Kallenberg C.G., and Bootsma H. Changes in salivary gland immunohistology and function after rituximab monotherapy in a patient with Sjogren's syndrome and associated MALT lymphoma. Ann Rheum Dis 64 (2005) 958-960
    • (2005) Ann Rheum Dis , vol.64 , pp. 958-960
    • Pijpe, J.1    van Imhoff, G.W.2    Vissink, A.3    van der Wal, J.E.4    Kluin, P.M.5    Spijkervet, F.K.6    Kallenberg, C.G.7    Bootsma, H.8
  • 27
    • 34047177483 scopus 로고    scopus 로고
    • Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjogren's syndrome
    • Seror R., Sordet C., Guillevin L., Hachulla E., Masson C., Ittah M., Candon S., Le Guern V., Aouba A., Sibilia J., et al. Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjogren's syndrome. Ann Rheum Dis 66 (2007) 351-357
    • (2007) Ann Rheum Dis , vol.66 , pp. 351-357
    • Seror, R.1    Sordet, C.2    Guillevin, L.3    Hachulla, E.4    Masson, C.5    Ittah, M.6    Candon, S.7    Le Guern, V.8    Aouba, A.9    Sibilia, J.10
  • 29
    • 12344330217 scopus 로고    scopus 로고
    • Induction of remission by B lymphocyte depletion in 11 patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis
    • Keogh K.A., Wylam M.E., Stone J.H., and Specks U. Induction of remission by B lymphocyte depletion in 11 patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 52 (2005) 262-268
    • (2005) Arthritis Rheum , vol.52 , pp. 262-268
    • Keogh, K.A.1    Wylam, M.E.2    Stone, J.H.3    Specks, U.4
  • 30
    • 33750214245 scopus 로고    scopus 로고
    • Long-term observation of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis treated with rituximab
    • Stasi R., Stipa E., Del Poeta G., Amadori S., Newland A.C., and Provan D. Long-term observation of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis treated with rituximab. Rheumatology (Oxford) 45 (2006) 1432-1436
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1432-1436
    • Stasi, R.1    Stipa, E.2    Del Poeta, G.3    Amadori, S.4    Newland, A.C.5    Provan, D.6
  • 31
    • 34548103678 scopus 로고    scopus 로고
    • Safety and clinical activity of ocrelizumab (a humanized antibody targeting CD20+ B Cells) in combination with methotrexate in moderate-severe rheumatoid arthritis patients (Ph I/II ACTION Study)
    • [abstract]
    • Genovese M.C., Kaine J.L., Kohen M.D., Lowenstein M.B., Giudice J.D., Baldassare A.R., Schechtman J., Gujrathi S., Trapp R.G., Sweiss N.J., et al. Safety and clinical activity of ocrelizumab (a humanized antibody targeting CD20+ B Cells) in combination with methotrexate in moderate-severe rheumatoid arthritis patients (Ph I/II ACTION Study). Arthritis Rheum 54 9 Suppl (2006) S66 [abstract]
    • (2006) Arthritis Rheum , vol.54 , Issue.9 SUPPL
    • Genovese, M.C.1    Kaine, J.L.2    Kohen, M.D.3    Lowenstein, M.B.4    Giudice, J.D.5    Baldassare, A.R.6    Schechtman, J.7    Gujrathi, S.8    Trapp, R.G.9    Sweiss, N.J.10
  • 32
    • 34250327709 scopus 로고    scopus 로고
    • HuMax-CD20, a novel fully human monoclonal IgG1 antibody in the treatment of rheumatoid arthritis
    • [abstract]
    • Østergaard M., Wiell C., Sierakowski S., Wallace D., Kastberg H., Petersen J., and Dawes P.T. HuMax-CD20, a novel fully human monoclonal IgG1 antibody in the treatment of rheumatoid arthritis. Arthritis Rheum 54 9 Suppl (2006) S832 [abstract]
    • (2006) Arthritis Rheum , vol.54 , Issue.9 SUPPL
    • Østergaard, M.1    Wiell, C.2    Sierakowski, S.3    Wallace, D.4    Kastberg, H.5    Petersen, J.6    Dawes, P.T.7
  • 33
    • 34249106357 scopus 로고    scopus 로고
    • TRU-015, a Small Modular ImmunoPharmaceutical (SMIP) drug candidate directed against CD20. Demonstrates clinical improvement in subjects with rheumatoid arthritis
    • [abstract]
    • Burge D.J., Shu C., Martin R.W., Littlejohn T.W., Wallace D.J., Taborn J., Palmer W.R., and Kivitz A. TRU-015, a Small Modular ImmunoPharmaceutical (SMIP) drug candidate directed against CD20. Demonstrates clinical improvement in subjects with rheumatoid arthritis. Arthritis Rheum 54 9 Suppl (2006) S230 [abstract]
    • (2006) Arthritis Rheum , vol.54 , Issue.9 SUPPL
    • Burge, D.J.1    Shu, C.2    Martin, R.W.3    Littlejohn, T.W.4    Wallace, D.J.5    Taborn, J.6    Palmer, W.R.7    Kivitz, A.8
  • 34
    • 18844424394 scopus 로고    scopus 로고
    • The role of CD22 and other inhibitory co-receptors in B-cell activation
    • Nitschke L. The role of CD22 and other inhibitory co-receptors in B-cell activation. Curr Opin Immunol 17 (2005) 290-297
    • (2005) Curr Opin Immunol , vol.17 , pp. 290-297
    • Nitschke, L.1
  • 36
    • 53749095799 scopus 로고    scopus 로고
    • Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
    • Dorner T., Kaufmann J., Wegener W.A., Teoh N., Goldenberg D.M., and Burmester G.R. Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus. Arthritis Res Ther 8 (2006) R74
    • (2006) Arthritis Res Ther , vol.8
    • Dorner, T.1    Kaufmann, J.2    Wegener, W.A.3    Teoh, N.4    Goldenberg, D.M.5    Burmester, G.R.6
  • 37
    • 33748778482 scopus 로고    scopus 로고
    • Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab
    • Carnahan J., Stein R., Qu Z., Hess K., Cesano A., Hansen H.J., and Goldenberg D.M. Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab. Mol Immunol 44 (2007) 1331-1341
    • (2007) Mol Immunol , vol.44 , pp. 1331-1341
    • Carnahan, J.1    Stein, R.2    Qu, Z.3    Hess, K.4    Cesano, A.5    Hansen, H.J.6    Goldenberg, D.M.7
  • 38
    • 34547131841 scopus 로고    scopus 로고
    • Polson AG, Yu SF, Elkins K, Zheng B, Clark S, Ingle GS, Slaga DS, Giere L, Du C, Tan C et al.: Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin's lymphoma. Blood 2007, March 20 [Epub ahead of print].
  • 39
    • 33845391101 scopus 로고    scopus 로고
    • Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity
    • Tedder T.F., Baras A., and Xiu Y. Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity. Springer Semin Immunopathol 28 (2006) 351-364
    • (2006) Springer Semin Immunopathol , vol.28 , pp. 351-364
    • Tedder, T.F.1    Baras, A.2    Xiu, Y.3
  • 40
    • 33750209982 scopus 로고    scopus 로고
    • Targeting BAFF: immunomodulation for autoimmune diseases
    • Sutherland A.P., Mackay F., and Mackay C.R. Targeting BAFF: immunomodulation for autoimmune diseases. Pharmacol Ther 112 (2006) 774-786
    • (2006) Pharmacol Ther , vol.112 , pp. 774-786
    • Sutherland, A.P.1    Mackay, F.2    Mackay, C.R.3
  • 41
  • 42
    • 33947592601 scopus 로고    scopus 로고
    • TACI regulates IgA production by APRIL in collaboration with HSPG
    • Sakurai D., Hase H., Kanno Y., Kojima H., Okumura K., and Kobata T. TACI regulates IgA production by APRIL in collaboration with HSPG. Blood 109 (2007) 2961-2967
    • (2007) Blood , vol.109 , pp. 2961-2967
    • Sakurai, D.1    Hase, H.2    Kanno, Y.3    Kojima, H.4    Okumura, K.5    Kobata, T.6
  • 43
    • 0037108490 scopus 로고    scopus 로고
    • BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
    • Roschke V., Sosnovtseva S., Ward C.D., Hong J.S., Smith R., Albert V., Stohl W., Baker K.P., Ullrich S., Nardelli B., et al. BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J Immunol 169 (2002) 4314-4321
    • (2002) J Immunol , vol.169 , pp. 4314-4321
    • Roschke, V.1    Sosnovtseva, S.2    Ward, C.D.3    Hong, J.S.4    Smith, R.5    Albert, V.6    Stohl, W.7    Baker, K.P.8    Ullrich, S.9    Nardelli, B.10
  • 44
    • 0034596831 scopus 로고    scopus 로고
    • Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response
    • Do R.K., Hatada E., Lee H., Tourigny M.R., Hilbert D., and Chen-Kiang S. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J Exp Med 192 (2000) 953-964
    • (2000) J Exp Med , vol.192 , pp. 953-964
    • Do, R.K.1    Hatada, E.2    Lee, H.3    Tourigny, M.R.4    Hilbert, D.5    Chen-Kiang, S.6
  • 45
    • 11844301640 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines
    • Ohata J., Zvaifler N.J., Nishio M., Boyle D.L., Kalled S.L., Carson D.A., and Kipps T.J. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol 174 (2005) 864-870
    • (2005) J Immunol , vol.174 , pp. 864-870
    • Ohata, J.1    Zvaifler, N.J.2    Nishio, M.3    Boyle, D.L.4    Kalled, S.L.5    Carson, D.A.6    Kipps, T.J.7
  • 47
    • 33646827589 scopus 로고    scopus 로고
    • Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects
    • Halpern W.G., Lappin P., Zanardi T., Cai W., Corcoran M., Zhong J., and Baker K.P. Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects. Toxicol Sci 91 (2006) 586-599
    • (2006) Toxicol Sci , vol.91 , pp. 586-599
    • Halpern, W.G.1    Lappin, P.2    Zanardi, T.3    Cai, W.4    Corcoran, M.5    Zhong, J.6    Baker, K.P.7
  • 48
    • 34548102544 scopus 로고    scopus 로고
    • Belimumab (fully human monoclonal antibody to B-lymphocyte stimulator [BLyS]) improves or stabilizes SLE activity in a multicenter phase 2 trial
    • [abstract]
    • Furie R., Lisse J., Merrill J.T., Petri M., Ginzler E., Aranow C., Weinstein A., Strand V., Weisman M.H., Diskin K., et al. Belimumab (fully human monoclonal antibody to B-lymphocyte stimulator [BLyS]) improves or stabilizes SLE activity in a multicenter phase 2 trial. Arthritis Rheum 54 9 Suppl (2006) S258 [abstract]
    • (2006) Arthritis Rheum , vol.54 , Issue.9 SUPPL
    • Furie, R.1    Lisse, J.2    Merrill, J.T.3    Petri, M.4    Ginzler, E.5    Aranow, C.6    Weinstein, A.7    Strand, V.8    Weisman, M.H.9    Diskin, K.10
  • 49
    • 34548061667 scopus 로고    scopus 로고
    • BR3-Fc Phase I Study: safety, pharmacokinetics (PK) and pharmacodynamic (PD) effects of a novel BR3-Fc fusion protein in patients with rheumatoid arthritis
    • [abstract]
    • Fleischmann R., Wei N., Shaw M., Birbara C., Anand B., Gujrathi S., Hendricks R., Rao T., Ren S., Weingart M., et al. BR3-Fc Phase I Study: safety, pharmacokinetics (PK) and pharmacodynamic (PD) effects of a novel BR3-Fc fusion protein in patients with rheumatoid arthritis. Arthritis Rheum 54 9 Suppl (2006) S229 [abstract]
    • (2006) Arthritis Rheum , vol.54 , Issue.9 SUPPL
    • Fleischmann, R.1    Wei, N.2    Shaw, M.3    Birbara, C.4    Anand, B.5    Gujrathi, S.6    Hendricks, R.7    Rao, T.8    Ren, S.9    Weingart, M.10
  • 50
    • 0141832116 scopus 로고    scopus 로고
    • Lymphotoxin/light, lymphoid microenvironments and autoimmune disease
    • Gommerman J.L., and Browning J.L. Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nat Rev Immunol 3 (2003) 642-655
    • (2003) Nat Rev Immunol , vol.3 , pp. 642-655
    • Gommerman, J.L.1    Browning, J.L.2
  • 52
    • 33749363027 scopus 로고    scopus 로고
    • CHARISMA Study Group: double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini R.N., Taylor P.C., Szechinski J., Pavelka K., Broll J., Balint G., Emery P., Raemen F., Petersen J., Smolen J., et al. CHARISMA Study Group: double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 54 (2006) 2817-2829
    • (2006) Arthritis Rheum , vol.54 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3    Pavelka, K.4    Broll, J.5    Balint, G.6    Emery, P.7    Raemen, F.8    Petersen, J.9    Smolen, J.10
  • 53
    • 25144498042 scopus 로고    scopus 로고
    • Reconstitution of the adult B cell repertoire after treatment with rituximab
    • Sanz I., and Anolik J. Reconstitution of the adult B cell repertoire after treatment with rituximab. Arthritis Res Ther 7 (2005) 175-176
    • (2005) Arthritis Res Ther , vol.7 , pp. 175-176
    • Sanz, I.1    Anolik, J.2
  • 54
    • 33746942234 scopus 로고    scopus 로고
    • Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis
    • Roll P., Palanichamy A., Kneitz C., Dorner T., and Tony H.P. Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis. Arthritis Rheum 54 (2006) 2377-2386
    • (2006) Arthritis Rheum , vol.54 , pp. 2377-2386
    • Roll, P.1    Palanichamy, A.2    Kneitz, C.3    Dorner, T.4    Tony, H.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.