Adult Langerhans cell histiocytosis with independently relapsing lung and liver lesions that was successfully treated with etoposide

Internal Medicine

Volumn 46, Issue 15, 2007, Pages 1231-1235

  Konno, Satoshi ^a   Hizawa, Nubuyuki ^a   Betsuyaku, Tomoko ^a   Yasuo, Masanori ^b   Yamamoto, Hiroshi ^b   Koizumi, Tomonobu ^b   Nishimura, Masaharu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Etoposide; Langerhans cell histiocytosis; Liver; Lung

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; CARBON MONOXIDE; CD1 ANTIGEN; CONTRAST MEDIUM; ETOPOSIDE; METHYLPREDNISOLONE SODIUM SUCCINATE; PREDNISOLONE; PROTEIN S 100; ANTINEOPLASTIC AGENT;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CASE REPORT; CELL INFILTRATION; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; COUGHING; DISEASE COURSE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG PULSE THERAPY; DRUG RESPONSE; EOSINOPHIL; ERYTHROCYTE SEDIMENTATION RATE; FEVER; FOLLOW UP; GRANULOMATOUS INFLAMMATION; HISTIOCYTOSIS X; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKOCYTOSIS; LIVER BIOPSY; LIVER NODULE; LUNG BIOPSY; LUNG CYST; LUNG DIFFUSION CAPACITY; LUNG FUNCTION TEST; MALE; MULTIPLE CYCLE TREATMENT; PROTEIN BLOOD LEVEL; RECURRENT DISEASE; RELAPSE; BIOPSY; LIVER; LIVER DISEASE; LUNG; LUNG DISEASE; PATHOLOGY;

ADULT; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOPSY; ETOPOSIDE; HISTIOCYTOSIS, LANGERHANS-CELL; HUMANS; LIVER; LIVER DISEASES; LUNG; LUNG DISEASES; MALE; RECURRENCE;

EID: 34548092124     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.46.6433     Document Type: Article

References (14)

1. Willman CL, Busque L, Griffith BB, et al. Langerhans'-cell histiocytosis (Histiocytosis X)- A clonal proliferative disease. N Engl J Med 331: 154-160, 1994.
2. Giona F, Caruso R, Testi AM, et al. Langerhans' cell histiocytosis in adults. Cancer 80: 1786-1791, 1997.
3. Malpas JS, Norton AJ. Langerhans cell histiocytosis in the adult. Med Pediatr Oncol 27: 540-546, 1996.
4. Yousem SA, Colby TV, Chen YY, Chen WG, Weiss LM. Pulmonary Langerhans' cell histiocytosis molecular analysis of clonarity. Am J Surg Pathol 25: 630-636, 2001.
5. Arico M. Langerhans cell histiocytosis in adults: more questions than answers? Eur J Cancer 40: 1467-1473, 2004.
6. Parker JW, Lichenstein L. severe hepatic involvement in chronic disseminated histiocytosis X. Report of a case with necropsy. Am J Clin Pathol 40: 624-632, 1963.
7. Sampathkumar S, Younger C, Cramer H, Chalasani N, Skiercynski PA. Langerhans' cell histiocytosis involving the pituitary, thyroid, lung, and liver. Endocr Pract 8: 217-221, 2002.
8. Nagai S, Kusumoto M, Yakushiji S, Yonemori K, Tateishi U, Maeshima A. A case of pulmonary Langerhans' cell histiocytosis with liver involvement. Nippon Kokyuki Gakkai Zasshi 42: 924-927, 2004 (in Japanese, Abstract in English).
9. Mogulkoc N, Veral A, Bishop P. Pulmonary Langerhans' cell histiocytosis: radiologic resolution following smoking cessation. Chest 115: 1452-1455, 1999.
10. Foschini MP, Milandri GL, Dina RE, Usellini L, Macchia S, Spongano P. Benign regression histiocytosis of the liver. Histopathology 26: 363-366, 1995.
11. Steiber AC, Sever C, Starzl TE. Liver transplantation in patients with Langerhans' cell histiocytosis. Transplantation 50: 338-340, 1990.
12. Konig CW, Pfannenberg C, Trubenberg J, et al. MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans' cell histiocytosis. Eur Radiol 11: 2561-2520, 2001.
13. Pirovino M, Jeanneret C, Hubert R, Luisier J, Bianchi L, Spichtin H. Liver cirrhosis in hisatiocytosis X Liver. 8: 293-298, 1998.
14. Morimoto A, Ikushima S, Kinugawa N, et al. Improved outcome in the treatment of pediatric multifocal Langerhans cell histiocytosis. Cancer 107: 613-619, 2006.