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Volumn 9, Issue 4, 2007, Pages 271-278

Intravenous busulfan: In the conditioning treatment of pediatric patients prior to hematopoietic stem cell transplantation

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIEMETIC AGENT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; BUSULFAN; CLONAZEPAM; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DIAZEPAM; FLUCONAZOLE; FOSPHENYTOIN SODIUM; GRANISETRON; ITRACONAZOLE; KETOBEMIDONE; LORAZEPAM; MELPHALAN; ONDANSETRON; PARACETAMOL; PHENYTOIN;

EID: 34548089422     PISSN: 11745878     EISSN: None     Source Type: Journal    
DOI: 10.2165/00148581-200709040-00008     Document Type: Review
Times cited : (23)

References (40)
  • 1
    • 33645299075 scopus 로고    scopus 로고
    • Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: Definitions and current practice in Europe
    • Mar;
    • Ljungman P, Urbano-Ispizua A, Cavazzana-Calvo M, et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. Bone Marrow Transplant 2006 Mar; 37 (5): 439-49
    • (2006) Bone Marrow Transplant , vol.37 , Issue.5 , pp. 439-449
    • Ljungman, P.1    Urbano-Ispizua, A.2    Cavazzana-Calvo, M.3
  • 2
    • 33646837336 scopus 로고    scopus 로고
    • Pretransplant conditioning in adults and children: Dose assurance with intravenous busulfan
    • Mar;
    • Fisher VL, Barnes YJ, Nuss SL. Pretransplant conditioning in adults and children: dose assurance with intravenous busulfan. Oncol Nurs Forum 2006 Mar; 33 (2): E36-43
    • (2006) Oncol Nurs Forum , vol.33 , Issue.2
    • Fisher, V.L.1    Barnes, Y.J.2    Nuss, S.L.3
  • 3
    • 2542473353 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation: A primer for the primary care physician
    • May 11;
    • Léger CS, Nevill TJ. Hematopoietic stem cell transplantation: a primer for the primary care physician. CMAJ 2004 May 11; 170 (10): 1569-77
    • (2004) CMAJ , vol.170 , Issue.10 , pp. 1569-1577
    • Léger, C.S.1    Nevill, T.J.2
  • 4
    • 34548085246 scopus 로고    scopus 로고
    • European Medicines Agency. Busilvex: European Public Assessment Report (EPAR) [online]. Available from URL: http://www.emea.europa.eu/humandocs/Humans/ EPAR/busilvex/busilvex.htm [Accessed 2007 May 9]
    • European Medicines Agency. Busilvex: European Public Assessment Report (EPAR) [online]. Available from URL: http://www.emea.europa.eu/humandocs/Humans/ EPAR/busilvex/busilvex.htm [Accessed 2007 May 9]
  • 5
    • 0033823462 scopus 로고    scopus 로고
    • Plasma concentration monitoring of busulfan: Does it improve clinical outcome?
    • Aug;
    • McCune JS, Gibbs JP, Slattery JT. Plasma concentration monitoring of busulfan: does it improve clinical outcome? Clin Pharmacokinet 2000 Aug; 39 (2): 155-65
    • (2000) Clin Pharmacokinet , vol.39 , Issue.2 , pp. 155-165
    • McCune, J.S.1    Gibbs, J.P.2    Slattery, J.T.3
  • 6
    • 0344034840 scopus 로고    scopus 로고
    • In children and adolescents, the pharmacodynamics of high-dose busulfan is dependent on the second alkylating agent used in the combined regimen (melphalan or thiotepa)
    • Nov;
    • Bouligand J, Boland I, Valteau-Couanet D, et al. In children and adolescents, the pharmacodynamics of high-dose busulfan is dependent on the second alkylating agent used in the combined regimen (melphalan or thiotepa). Bone Marrow Transplant 2003 Nov; 32 (10): 979-86
    • (2003) Bone Marrow Transplant , vol.32 , Issue.10 , pp. 979-986
    • Bouligand, J.1    Boland, I.2    Valteau-Couanet, D.3
  • 7
    • 0024428426 scopus 로고
    • Pharmacokinetics of high-dose busulfan in children
    • Vassal G, Gouyette A, Hartmann O, et al. Pharmacokinetics of high-dose busulfan in children. Cancer Chemother Pharmacol 1989; 24 (6): 386-90
    • (1989) Cancer Chemother Pharmacol , vol.24 , Issue.6 , pp. 386-390
    • Vassal, G.1    Gouyette, A.2    Hartmann, O.3
  • 8
    • 33845753369 scopus 로고    scopus 로고
    • Population pharmacokinetic-based dosing of intravenous busulfan in pediatric patients
    • Jan;
    • Booth BP, Rahman A, Dagher R, et al. Population pharmacokinetic-based dosing of intravenous busulfan in pediatric patients. J Clin Pharmacol 2007 Jan; 47 (1): 101-11
    • (2007) J Clin Pharmacol , vol.47 , Issue.1 , pp. 101-111
    • Booth, B.P.1    Rahman, A.2    Dagher, R.3
  • 9
    • 33644651909 scopus 로고    scopus 로고
    • Quantification of busulfan in saliva and plasma in haematopoietic stem cell transplantation in children: Validation of liquid chromatography tandem mass spectrometry method
    • Rauh M, Stachel D, Kuhlen M, et al. Quantification of busulfan in saliva and plasma in haematopoietic stem cell transplantation in children: validation of liquid chromatography tandem mass spectrometry method. Clin Pharmacokinet 2006; 45 (3): 305-16
    • (2006) Clin Pharmacokinet , vol.45 , Issue.3 , pp. 305-316
    • Rauh, M.1    Stachel, D.2    Kuhlen, M.3
  • 10
    • 2942530481 scopus 로고    scopus 로고
    • Nguyen L, Fuller D, Lennon S, et al. I.V. busulfan in pediatrics: a novel dosing to improve safety/efficacy for hematopoietic progenitor cell transplantation recipients. Bone Marrow Transplant 2004 May; 33 (10): 979-87
    • Nguyen L, Fuller D, Lennon S, et al. I.V. busulfan in pediatrics: a novel dosing to improve safety/efficacy for hematopoietic progenitor cell transplantation recipients. Bone Marrow Transplant 2004 May; 33 (10): 979-87
  • 12
    • 0028556958 scopus 로고    scopus 로고
    • Vassal G. Pharmacologically-guided dose adjustment of busulfan in high-dose chemotherapy regimens: rationale and pitfalls (review). Anticancer Res 1994 Nov-Dec 31; 14 (6A): 2363-70
    • Vassal G. Pharmacologically-guided dose adjustment of busulfan in high-dose chemotherapy regimens: rationale and pitfalls (review). Anticancer Res 1994 Nov-Dec 31; 14 (6A): 2363-70
  • 13
    • 0034960016 scopus 로고    scopus 로고
    • Busulfan levels are influenced by prior treatment and are associated with hepatic veno-occlusive disease and early mortality but not with delayed complications following marrow transplantation
    • Jun;
    • Copelan EA, Bechtel TP, Avalos BR, et al. Busulfan levels are influenced by prior treatment and are associated with hepatic veno-occlusive disease and early mortality but not with delayed complications following marrow transplantation. Bone Marrow Transplant 2001 Jun; 27 (11): 1121-4
    • (2001) Bone Marrow Transplant , vol.27 , Issue.11 , pp. 1121-1124
    • Copelan, E.A.1    Bechtel, T.P.2    Avalos, B.R.3
  • 14
    • 6444243739 scopus 로고    scopus 로고
    • Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem cell transplantation
    • Nov;
    • Tran H, Petropoulos D, Worth L, et al. Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2004 Nov; 10 (11): 805-12
    • (2004) Biol Blood Marrow Transplant , vol.10 , Issue.11 , pp. 805-812
    • Tran, H.1    Petropoulos, D.2    Worth, L.3
  • 15
    • 0029655526 scopus 로고    scopus 로고
    • Busulfan disposition and hepatic veno-occlusive disease in children undergoing bone marrow transplantation
    • Vassal G, Koscielny S, Challine D, et al. Busulfan disposition and hepatic veno-occlusive disease in children undergoing bone marrow transplantation. Cancer Chemother Pharmacol 1996; 37 (3): 247-53
    • (1996) Cancer Chemother Pharmacol , vol.37 , Issue.3 , pp. 247-253
    • Vassal, G.1    Koscielny, S.2    Challine, D.3
  • 16
    • 0027934151 scopus 로고
    • Busulfan bioavailability
    • Hassan M, Ljungman P, Bolme P, et al. Busulfan bioavailability. Blood 1994; 84 (7): 2144-50
    • (1994) Blood , vol.84 , Issue.7 , pp. 2144-2150
    • Hassan, M.1    Ljungman, P.2    Bolme, P.3
  • 17
    • 0030770990 scopus 로고    scopus 로고
    • High busulfan concentrations are associated with increased transplant-related mortality in allogeneic bone marrow transplant patients
    • Dec;
    • Ljungman P, Hassan M, Bekassy AN, et al. High busulfan concentrations are associated with increased transplant-related mortality in allogeneic bone marrow transplant patients. Bone Marrow Transplant 1997 Dec; 20 (11): 909-13
    • (1997) Bone Marrow Transplant , vol.20 , Issue.11 , pp. 909-913
    • Ljungman, P.1    Hassan, M.2    Bekassy, A.N.3
  • 18
    • 0029057117 scopus 로고
    • Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics
    • Jul;
    • Slattery JT, Sanders JE, Buckner CD, et al. Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. Bone Marrow Transplant 1995 Jul; 16 (1): 31-42
    • (1995) Bone Marrow Transplant , vol.16 , Issue.1 , pp. 31-42
    • Slattery, J.T.1    Sanders, J.E.2    Buckner, C.D.3
  • 19
    • 0032848730 scopus 로고    scopus 로고
    • The role of busulfan in bone marrow transplantation
    • Hassan M. The role of busulfan in bone marrow transplantation. Med Oncol 1999; 16 (3): 166-76
    • (1999) Med Oncol , vol.16 , Issue.3 , pp. 166-176
    • Hassan, M.1
  • 21
    • 84976585919 scopus 로고    scopus 로고
    • European Medicines Agency, online, Available from URL:, Accessed May 9
    • European Medicines Agency. Busilvex: summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/humandocs/Humans/EPAR/ busilvex/busilvex.htm [Accessed 2007 May 9]
    • (2007) Busilvex: Summary of product characteristics
  • 22
    • 0033677280 scopus 로고    scopus 로고
    • Reproductive status in long-term bone marrow transplant survivors receiving busulfan-cyclophosphamide (120 mg/kg)
    • Nov;
    • Grigg AP, McLachlan R, Zaja J, et al. Reproductive status in long-term bone marrow transplant survivors receiving busulfan-cyclophosphamide (120 mg/kg). Bone Marrow Transplant 2000 Nov; 26 (10): 1089-95
    • (2000) Bone Marrow Transplant , vol.26 , Issue.10 , pp. 1089-1095
    • Grigg, A.P.1    McLachlan, R.2    Zaja, J.3
  • 23
    • 0031722549 scopus 로고    scopus 로고
    • Ovarian function after autologous bone marrow transplantation in childhood: High-dose busulfan is a major cause of ovarian failure
    • Nov;
    • Teinturier C, Hartmann O, Valteau-Couanet D, et al. Ovarian function after autologous bone marrow transplantation in childhood: high-dose busulfan is a major cause of ovarian failure. Bone Marrow Transplant 1998 Nov; 22 (10): 989-94
    • (1998) Bone Marrow Transplant , vol.22 , Issue.10 , pp. 989-994
    • Teinturier, C.1    Hartmann, O.2    Valteau-Couanet, D.3
  • 24
    • 34347371274 scopus 로고    scopus 로고
    • Children with sickle cell disease: Growth and gonadal function after hematopoietic stem cell transplantation
    • Jul;
    • Brachet C, Heinrichs C, Tenoutasse S, et al. Children with sickle cell disease: growth and gonadal function after hematopoietic stem cell transplantation. J Pediatr Hematol Oncol 2007 Jul; 29 (7): 445-50
    • (2007) J Pediatr Hematol Oncol , vol.29 , Issue.7 , pp. 445-450
    • Brachet, C.1    Heinrichs, C.2    Tenoutasse, S.3
  • 25
    • 34249079100 scopus 로고    scopus 로고
    • Cytotoxicity of dimethylacetamide and pharmacokinetics in children receiving intravenous busulfan
    • May 1;
    • Hempel G, Oechtering D, Lanvers-Kaminsky C, et al. Cytotoxicity of dimethylacetamide and pharmacokinetics in children receiving intravenous busulfan. J Clin Oncol 2007 May 1; 25 (13): 1772-8
    • (2007) J Clin Oncol , vol.25 , Issue.13 , pp. 1772-1778
    • Hempel, G.1    Oechtering, D.2    Lanvers-Kaminsky, C.3
  • 26
    • 33847079603 scopus 로고    scopus 로고
    • Pharmacokinetic disposition and clinical outcomes in infants and children receiving intravenous busulfan for allogeneic hematopoietic stem cell transplantation
    • Mar;
    • Schechter T, Finkelstein Y, Doyle J, et al. Pharmacokinetic disposition and clinical outcomes in infants and children receiving intravenous busulfan for allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2007 Mar; 13 (3): 307-14
    • (2007) Biol Blood Marrow Transplant , vol.13 , Issue.3 , pp. 307-314
    • Schechter, T.1    Finkelstein, Y.2    Doyle, J.3
  • 27
    • 33748992558 scopus 로고    scopus 로고
    • Once-daily intravenous busulfan in children prior to stem cell transplantation: Study of pharmacokinetics and early clinical outcomes
    • Oct;
    • Zwaveling J, den Hartigh J, Lankester AC, et al. Once-daily intravenous busulfan in children prior to stem cell transplantation: study of pharmacokinetics and early clinical outcomes. Anticancer Drugs 2006 Oct; 17 (9): 1099-105
    • (2006) Anticancer Drugs , vol.17 , Issue.9 , pp. 1099-1105
    • Zwaveling, J.1    den Hartigh, J.2    Lankester, A.C.3
  • 28
    • 34548079351 scopus 로고    scopus 로고
    • Population pharmacokinetic of intravenous busulfan in children [abstract no. PII-98]
    • Mar 1;
    • Kassir N, Theoret DY, Champagne MA, et al. Population pharmacokinetic of intravenous busulfan in children [abstract no. PII-98]. Clin Pharmacol Ther 2007 Mar 1; 81 Suppl. 1: S81
    • (2007) Clin Pharmacol Ther , vol.81 , Issue.SUPPL. 1
    • Kassir, N.1    Theoret, D.Y.2    Champagne, M.A.3
  • 29
    • 0031454073 scopus 로고    scopus 로고
    • Age-dependent tetrahydrothiophenium ion formation in young children and adults recieving high-dose busulfan
    • Gibbs J-P, Murray G, Risler L, et al. Age-dependent tetrahydrothiophenium ion formation in young children and adults recieving high-dose busulfan. Cancer Res 1997; 57: 5509-16
    • (1997) Cancer Res , vol.57 , pp. 5509-5516
    • Gibbs, J.-P.1    Murray, G.2    Risler, L.3
  • 30
    • 0032744935 scopus 로고    scopus 로고
    • Up-regulation of glutathione S-transferase activity in enterocytes of young children
    • Gibbs J-P, Liacouras C-A, Baldassano R-N, et al. Up-regulation of glutathione S-transferase activity in enterocytes of young children. Drug Metab Dispos 1999; 27 (12): 1466-9
    • (1999) Drug Metab Dispos , vol.27 , Issue.12 , pp. 1466-1469
    • Gibbs, J.-P.1    Liacouras, C.-A.2    Baldassano, R.-N.3
  • 31
    • 34548078479 scopus 로고    scopus 로고
    • Pharmacogenetics of busulfan in pediatric patients undergoing hematopoietic cell transplantation (HCT)
    • abstract no. 738, Apr 14-18; Los Angeles CA
    • Johnson LA, Orchard P, Baker KS, et al. Pharmacogenetics of busulfan in pediatric patients undergoing hematopoietic cell transplantation (HCT) [abstract no. 738]. 98th Annual Meeting of the American Association for Cancer Research; 2007 Apr 14-18; Los Angeles (CA)
    • (2007) 98th Annual Meeting of the American Association for Cancer Research
    • Johnson, L.A.1    Orchard, P.2    Baker, K.S.3
  • 32
    • 34548070596 scopus 로고    scopus 로고
    • Influence of glutathione S-transferase T1 gene polymorphism on the pharmacokinetics of intravenous busulfan [abstract no. 734]
    • Apr 14-18; Los Angeles CA
    • Lee JH, Ryu SG, Choi SJ, et al. Influence of glutathione S-transferase T1 gene polymorphism on the pharmacokinetics of intravenous busulfan [abstract no. 734]. 98th Annual Meeting of the American Association for Cancer Research; 2007 Apr 14-18; Los Angeles (CA)
    • (2007) 98th Annual Meeting of the American Association for Cancer Research
    • Lee, J.H.1    Ryu, S.G.2    Choi, S.J.3
  • 33
    • 0034021677 scopus 로고    scopus 로고
    • The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: Time interval influence on therapeutic efficacy and therapy-related toxicity
    • May;
    • Hassan M, Ljungman P, Ringden O, et al. The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicity. Bone Marrow Transplant 2000 May; 25 (9): 915-24
    • (2000) Bone Marrow Transplant , vol.25 , Issue.9 , pp. 915-924
    • Hassan, M.1    Ljungman, P.2    Ringden, O.3
  • 34
    • 9444277948 scopus 로고    scopus 로고
    • Buggia I, Zecca M, Alessandrino EP, et al. Itraconazole can increase systemic exposure to busulfan in patients given bone marrow transplantation. GITMO (Gruppo Italiano Trapianto di Midollo Osseo). Anticancer Res 1996 Jul-Aug; 16 (4A): 2083-8
    • Buggia I, Zecca M, Alessandrino EP, et al. Itraconazole can increase systemic exposure to busulfan in patients given bone marrow transplantation. GITMO (Gruppo Italiano Trapianto di Midollo Osseo). Anticancer Res 1996 Jul-Aug; 16 (4A): 2083-8
  • 35
    • 34548084972 scopus 로고    scopus 로고
    • Valteau-Couanet D, Gentet JC, Doz F, et al. Body-weight-based I.V. busulfan fixed dosing as part of BuMel regimen before autologous transplantation in children with high risk solid tumors: reduced toxicities in the French prospective multicentre study [abstract no. 0354]. Haematologica 2006 Jun 1; 91 Suppl. 1: 131. Plus poster presented at the 11th Congress of the European Haematology Association; 2006 Jun 15-18; Amsterdam
    • Valteau-Couanet D, Gentet JC, Doz F, et al. Body-weight-based I.V. busulfan fixed dosing as part of BuMel regimen before autologous transplantation in children with high risk solid tumors: reduced toxicities in the French prospective multicentre study [abstract no. 0354]. Haematologica 2006 Jun 1; 91 Suppl. 1: 131. Plus poster presented at the 11th Congress of the European Haematology Association; 2006 Jun 15-18; Amsterdam
  • 36
    • 34548080173 scopus 로고    scopus 로고
    • Michel G, Valteau-Counanet, D, Esperou, H. A new I.V. busulfan fixed dosing for conditioning before autologous or allogeneic hematopoietic stem cell transplantation in children with malignant and non-malignant diseases: pharmacokinetics, toxicity and clinical outcomes [abstract no. 1758]. Blood 2005; 106 (11 Pt 1): 500a. Plus poster presented at the 47th Annual Meeting of the American Society of Hematology; 2005 Dec 10-13; Atlanta (GA)
    • Michel G, Valteau-Counanet, D, Esperou, H. A new I.V. busulfan fixed dosing for conditioning before autologous or allogeneic hematopoietic stem cell transplantation in children with malignant and non-malignant diseases: pharmacokinetics, toxicity and clinical outcomes [abstract no. 1758]. Blood 2005; 106 (11 Pt 1): 500a. Plus poster presented at the 47th Annual Meeting of the American Society of Hematology; 2005 Dec 10-13; Atlanta (GA)
  • 37
    • 34548084683 scopus 로고    scopus 로고
    • Esperou H, Vassal G, Mechinaud F, et al. A dose finding study of I.V. busulfan in combination with cyclophosphamide as conditioning regimen prior allogeneic stem cell transplantation in children with malignant and non-malignant haematological diseases: optimisation of busulfan treatment [abstract no. 0819]. Haematologica 2006 Jun 1; 91 Suppl. 1: 301. Plus poster presented at the 11th Congress of the European Haematology Association; 2006 Jun 15-18; Amsterdam
    • Esperou H, Vassal G, Mechinaud F, et al. A dose finding study of I.V. busulfan in combination with cyclophosphamide as conditioning regimen prior allogeneic stem cell transplantation in children with malignant and non-malignant haematological diseases: optimisation of busulfan treatment [abstract no. 0819]. Haematologica 2006 Jun 1; 91 Suppl. 1: 301. Plus poster presented at the 11th Congress of the European Haematology Association; 2006 Jun 15-18; Amsterdam
  • 38
    • 0025121395 scopus 로고
    • Dose-dependent neurotoxicity of high-dose busulfan in children: A clinical and pharmacological study
    • Oct 1;
    • Vassal G, Deroussent A, Hartmann O, et al. Dose-dependent neurotoxicity of high-dose busulfan in children: a clinical and pharmacological study. Cancer Res 1990 Oct 1; 50 (19): 6203-7
    • (1990) Cancer Res , vol.50 , Issue.19 , pp. 6203-6207
    • Vassal, G.1    Deroussent, A.2    Hartmann, O.3
  • 39
    • 0032620465 scopus 로고    scopus 로고
    • Veno-occlusive disease of the liver after busulfan, melphalan, and thiotepa conditioning therapy: Incidence, risk factors, and outcome
    • Lee JL, Gooley T, Bensinger W, et al. Veno-occlusive disease of the liver after busulfan, melphalan, and thiotepa conditioning therapy: incidence, risk factors, and outcome. Biol Blood Marrow Transplant 1999; 5 (5): 306-15
    • (1999) Biol Blood Marrow Transplant , vol.5 , Issue.5 , pp. 306-315
    • Lee, J.L.1    Gooley, T.2    Bensinger, W.3
  • 40
    • 0035179652 scopus 로고    scopus 로고
    • Improved clinical outcome of paediatric bone marrow recipients using a test dose and Bayesian pharmacokinetic individualization of busulfan dosage regimens
    • Oct;
    • Bleyzac N, Souillet G, Magron P, et al. Improved clinical outcome of paediatric bone marrow recipients using a test dose and Bayesian pharmacokinetic individualization of busulfan dosage regimens. Bone Marrow Transplant 2001 Oct; 28 (8): 743-51
    • (2001) Bone Marrow Transplant , vol.28 , Issue.8 , pp. 743-751
    • Bleyzac, N.1    Souillet, G.2    Magron, P.3


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