Is opiate addiction associated with longstanding neurobiological changes?

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 19, Issue 3, 2007, Pages 242-248

  Martin, Michele ^a   Hurley, Robin A ^a,b,c,d   Taber, Katherine H ^b,c,d,e  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Education and Clinical Center   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COGNITIVE DEFECT; HUMAN; NEUROBIOLOGY; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL;

EID: 34548071670     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.2007.19.3.242     Document Type: Article

References (68)

1. Schadrack J, Willoch F, Platzer S, et al: Opioid receptors in the human cerebellum: evidence from [11C]diprenorphine PET, mRNA expression and autoradiography. Neuroreport 1999; 10:619-624
2. Wester HJ, Willoch F, Tolle TR, et al: 6-0-(2-[18F]fluoroethyl)-6-0- desmethyldiprenophine ([18F]DPN): synthesis, biologic evaluation, and comparison with [11C]DPN in humans. J Nucl Med 2000; 41:1279-1286
3. Willoch F, Schindler F, Wester HJ, et al: Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study. Pain 2004; 108:213-220
4. Baumgartner U, Buchholz HG, Bellosevich A, et al: High opiate receptor binding potential in the human lateral pain system. Neuroimage 2006; 30:692-699
5. Lee TM, Zhou WH, Luo XJ, et al: Neural activity associated with cognitive regulation in heroin users: an fMRI study. Neurosci Lett 2005; 382:211-216
6. Yucel M, Lubman DI, Harrison BJ, et al: A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction. Mol Psychiatry 2007; 12:691-702
7. Brownstein MJ: A brief history of opiates, opioid peptides, and opioid receptors. Proc Natl Acad Sci U S A: 1993; 90:5391-5393
8. Aggrawal A: Narcotic Drugs. New Delhi, National Book Trust, India 1995
9. Martin WR, Eades CG, Thompson JA, et al: The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 1976; 197:517-532
10. Mansour A, Khachaturian H, Lewis ME, et al: Anatomy of CNS opioid receptors. Trends Neurosci 1988; 11:308-314
11. Pfeiffer A, Pasi A, Mehraein P, et al: Opiate receptor binding sites in human brain. Brain Res 1982; 248:87-96
12. Cross AJ, Hille C, Slater P: Subtraction autoradiography of opiate receptor subtypes in human brain. Brain Res 1987; 418:343-348
13. Pilapil C, Weiner S, Magnan J, et al: Autoradiographic distribution of multiple classes of opioid receptor binding sites in human forebrain. Brain Res Bull 1987; 19:611-615
14. Mathieu-Kia AM, Fan LQ, Kreek MJ, et al: Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients. Brain Res 2001; 893:121-134
15. Hammers A, Lingford-Hughes A: Opioid imaging. Neuroimaging Clin N Am 2006; 16:529-552
16. Royston MC, Slater P, Simpson MD, et al: Analysis of laminar distribution of kappa opiate receptor in human cortex: comparison between schizophrenia and normal. J Neurosci Methods 1991; 36:145-153
17. Blackburn TP, Cross AJ, Hille C, et al: Autoradiographic localization of delta opiate receptors in rat and human brain. Neuroscience 1988; 27:497-506
18. Gianoulakis C: Endogenous opioids and addiction to alcohol and other drugs of abuse. Curr Top Med Chem 2004; 4:39-50
19. Schlaepfer TE, Strain EC, Greenberg BD, et al: Site of opiod action in the human brain: mu and kappa agonists' subjective and cerebral blood flow effects. Am J Psychiatry 1998; 155:470-473
20. Borne J, Riascos R, Cuellar H, et al: Neuroimaging in drug and substance abuse, part II: opioids and solvents. Top Magn Reson Imaging 2005; 16:239-245
21. Ravert HT, Bencherif B, Madar I, et al: PET imaging of opioid receptors in pain: progress and new directions. Curr Pharm Des 2004; 10:759-768
22. Talbot PS, Narendran R, Butelman ER, et al: 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons. J Nucl Med 2005; 46:484-494
23. Madar I, Lever JR, Kinter CM, et al: Imaging of delta opioid receptors in human brain by N1[prime]-([11C]methyl) naltrindole and PET. Synapse 1996; 24:19-28
24. Smith JS, Zubieta JK, Price JC, et al: Quantification of delta-opioid receptors in human brain with N1-([11C]methyl) naltrindole and positron emission tomography. J Cereb Blood Flow Metab 1999; 19:956-966
25. Hser YI, Hoffman V, Grella CE, et al: A 33-year follow-up of narcotics addicts. Arch Gen Psychiatry 2001; 58:503-508
26. Buttner A, Mall G, Penning R, et al: The neuropathology of heroin abuse. Forensic Sci Int 2000; 113:435-442
27. Kivisaari R, Kahkonen S, Puuskari V, et al: Magnetic resonance imaging of severe, long-term, opiate-abuse patients without neurologic sysptoms may show enlarged cerebrospinal spaces but no signs of brain pathology of vascular origin. Arch Med Res 2004; 35:395-400
28. Wolters EC, van Wijngaarden GK, Stam FC, et al: Leucoencephalopathy after inhaling "heroin" pyrolysate. Lancet 1982; 320:1233-1237
29. Hagel J, Andrews G, Vertinsky T, et al: "Chasing the dragon" - imaging of heroin inhalation leukoencephalopathy. Can Assoc Radiol J 2005; 56:199-203
30. Kriegstein AR, Shungu DC, Millar WS, et al: Leukoencephalopathy and raised brain lactate from heroin vapor inhalation ("chasing the dragon"). Neurology 1999; 53:1765-1773
31. Keogh CF, Andrews GT, Spacey SD, et al: Neuroimaging features of heroin inhalation toxicity: "chasing the dragon." Am J Roentgenol 2003; 180:847-850
32. Ryan A, Molloy FM, Farrell MA, et al: Fatal toxic leukoencephalopathy: clinical, radiological, and necropsy findings in two patients. J Neurol Neurosurg Psychiatry 2005; 76:1014-1016
33. Vella S, Kreis R, Lovblad KO, et al: Acute leukoencephalopathy after inhalation of a single dose of heroin. Neuropediatrics 2003; 34:100-104
34. Gacouin A, Lavoue S, Signouret T, et al: Reversible spongiform leucoencephalopathy after inhalation of heated heroin. Intensive Care Med 2003; 29:1012-1015
35. Lyoo IK, Pollak MH, Silveri MM, et al: Prefrontal and temporal gray matter density decreases in opiate dependence. Psychopharmacology (Berl) 2006; 184:139-144
36. Haselhorst R, Dursteler-MacFarland KM, Scheffler K, et al: Frontocortical N-acetylaspartate reduction associated with long-term i.v. heroin use. Neurology 2002; 58:305-307
37. Krystal JH, Woods SW, Kosten TR, et al: Opiate dependence and withdrawal: preliminary assessment using single photon emission computerized tomography (SPECT). Am J Drug Alcohol Abuse 1995; 21:47-63
38. Pezawas L, Fischer G, Podreka I, et al: Opioid addiction changes cerebral blood flow symmetry. Neuropsychobiology 2002; 45:67-73
39. Botelho MF, Relvas JS, Abrantes M, et al: Brain blood flow SPECT imaging in herion abusers. Ann N Y Acad Sci 2006; 1074:466-477
40. Rose JS, Branchey M, Buydens-Branchey L, et al: Cerebral perfusion in early and late opiate withdrawal: a technetium-99m-HMPAO SPECT study. Psychiatry Res 1996; 67:39-47
41. Danos P, Kasper S, Grunwald F, et al: Pathological regional cerebral blood flow in opiate-dependent patients during withdrawal: an HMPAO-SPECT study. Neuropsychobiology 1998; 37:194-199
42. Galynker I, Watras-Ganz S, Miner C, et al: Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance. Mt Sinai J Med 2000; 67:381-387
43. Grant S, Contoreggi C, London ED: Drug abusers show impaired performance in a laboratory test of decision making. Neuropsychologia 2000; 38:1180-1187
44. Dom G, Sabbe B, Hulstijn W, et al: Substance use disorders and the obitofrontal cortex: systematic review of behavioural decision-making and neuroimaging studies. Br J Psychiatry 2005; 187:209-220
45. Verdejo-Garcia AJ, Perales JC, Perez-Garcia M: Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addict Behav 2007; 32:950-966
46. Verdejo-Garcia A, Perez-Garcia M: Profile of executive deficits in cocaine and heroin polysubstance users: common and differential effects on separate executive components. Psychopharmacology (Berl) 2007; 190:517-530
47. Mattick RP, Breen C, Kimber J, et al: Methadone maintenance therapy versus no opiod replacement therapy for opioid dependence. Cochrane Database Syst Rev 2003; 2:CD002209 DOI:101002/14651858.CD002209
48. Specka M, Finkbeiner T, Lodemann E, et al: Cognitive-motor performance of methadone-maintained patients. Eur Addict Res 2000; 6:8-19
49. Darke S, Sims J, McDonald S, Wickes W: Cognitive impairment among methadone maintenance patients. Addiction 2000; 95:687-695
50. Ornstein TJ, Iddon JL, Baldacchino AM, et al: Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers. Neuropsychopharmacology 2000; 23:113-126
51. Mintzer MZ, Stitzer ML: Cognitive impairment in methadone maintenance patients. Drug Alcohol Depend 2002; 67:41-51
52. Davis PE, Liddiard H, McMillan TM: Neuropsychological deficits and opiate abuse. Drug Alcohol Depend 2002; 67:105-108
53. Prosser J, Cohen LJ, Steinfeld M, et al: Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment. Drug Alcohol Depend 2006; 84:240-247
54. Pirastu R, Fais R, Messina M, et al: Impaired decision-making in opiate-dependent subjects: effect of pharmacological therapies. Drug Alcohol Depend 2006; 83:163-168
55. Ersche KD, Clark L, London M, et al: Profile of executive and memory function associated with amphetamine and opiate dependence. Neuropsychopharmacology 2006; 31:1036-1047
56. Vassileva J, Petkova P, Georgiev S, et al: Impaired decision-making in psychopathic heroin addicts. Drug Alcohol Depend 2007; 86:287-289
57. Gruber SA, Tzilos GK, Silveri MM, et al: Methadone maintenance improves cognitive performance after two months of treatment. Exp Clin Psychopharmacol 2006; 14:157-164
58. Martin-Soelch C, Chevalley AF, Kunig G, et al: Changes in reward-induced brain activation in opiate addicts. Eur J Neurosci 2001; 14:1360-1368
59. Mintzer MZ, Copersino ML, Stitzer ML: Opioid abuse and cognitive performance. Drug Alcohol Depend 2005; 78:225-230
60. Verdejo A, Torbibio I, Orozco C, et al: Neuropsycological functioning in methadohne maintenance patients versus abstinent heroin abusers. Drug Alcohol Depend 2005; 78:283-288
61. Clark L, Robbins TW, Ersche KD, et al: Reflection impulsivity in current and former substance users. Biol Psychiatry 2006; 60:515-522
62. Ersche KD, Fletcher PC, Lewis SJ, et al: Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals. Psychopharmacology (Berl) 2005; 180:612-623
63. Ersche KD, Roiser JP, Clark L, et al: Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers. Neuropsychopharmacology 2005; 30:2115-2124
64. Curran HV, Kleckham J, Bearn J, et al: Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: a dose-response study. Psychopharmacology (Berl) 2001; 154:153-160
65. Mintzer MZ, Correia CJ, Strain EC: A dose-effect study of repeated administration of buprenophine/naloxone on performance in opioid-dependent volunteers. Drug Alcohol Depend 2004; 74:205-209
66. Soyka M, Hock B, Kagerer S, et al: Less impairment on one portion of a driving-relevent psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial. J Clin Psychopharmacol 2005; 25:490-493
67. Gerra G, Zaimovic A, Raggi MA, et al: Experimentally induced aggressiveness in heroin-dependent patients treated with buprenorphine: comparison of patients receiving methadone and healthy subjects. Psychiatry Res 2007; 149:201-213
68. Forman SD, Dougherty GG, Casey BJ, et al: Opiate addicts lack error-dependent activation of rostral anterior cingulate. Biol Psychiatry 2004; 55:531-537