Protective role of Phyllantus niruri extract on serum lipid profiles and oxidative stress in hepatocytes of diabetic rats

African Journal of Biotechnology

Volumn 6, Issue 15, 2007, Pages 1744-1749

  Nwanjo, H U ^a   Oze, G ^a   Okafor, M C ^a   Nwosu, D ^a   Nwankpa, P ^a  

^a IMO STATE UNIVERSITY   (Nigeria)

Author keywords

Lipids and hepatocytes; Oxidative stress; Phyllanthus niruri

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; CHOLESTEROL; EUPHORBIA EXTRACT; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PHOSPHOLIPID; PHYLLANTHUS NIRURI EXTRACT; SCAVENGER; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; DYSLIPIDEMIA; ENZYME ACTIVITY; EUPHORBIA; LD 50; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER CELL; MALE; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; PHYLLANTHUS NIRURI; RAT;

PHYLLANTHUS NIRURI; RATTUS;

EID: 34548068554     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: 10.5897/AJB2007.000-2256     Document Type: Article

References (33)

1. Aguwa CN (1996): Diabetes Mellitus. In therapeutic Basis of clinical pharmacy in the tropics. Optimal Publishers, Enugu, Nigeria, pp 1-453.
2. Anuradha CV, Selvam R (1993). Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan induced diabetic rats J. Nutr Biochem 4: 212-217.
3. Baynes JW (1991). Role of oxidative stress in development of complications in diabetes. Diabetes. 40: 405-412
4. Bierman EL (1992). Atherogenesis in diabetes. Arterioscler. Thromb.12: 647-656.
5. Brownlee M, Cerami A (1981). The biochemistry of the complication of diabetes mellitus. Ann Rev. Biochem. 50: 385-432.
6. Cetto AA, Weidonfeld H, Revilla MC, Sergio IA (2000) Hypoglycaemic effect of Equisetum mriochaetum aerial parts on STZ-diabetic rats. J. Ethnopharmacol. 72: 129-133.
7. Chopra RN, Nayar SL, Chopra IC (1986) Glossary of Indian medicinal plants CSIR, New Delhi. Catholic press. Ranchi, India,
8. Desai ID (1984). Vitamin E analysis method for animal tissues methods. Enzymology 105: 138-143.
9. Duncan BD (1957). Multiple range tests for correlated and heteroscedastic means. Biometrics 13: 359-364.
10. Ellman GC (1959). Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82: 70-77
11. Folch J, Less M, Solane SGH (1957). A simple method for isolation and purification of total lipids from animal tissues J. Biol. Chem. 226: 497-509.
12. Ghosh MN (1084). Fundamentals of experimental pharmacology. 2nd ed. Calculta: Scientific Book Agency.
13. Kakkar P, Das B, Viswanathan PN (1984). A modified spectroscopic assay of superoxide dismutase. Indian Biochem. Biophys. 21:130-132.
14. Kakkar P, Kalra J, Mantha SV, prasad K (1995). Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Mol. cell. Biochem. 151: 113-119.
15. Hardnett EM, Stratton RD, Browne RW, Rosner BA, Lanham RJ, Armstrong D (2000). Serum markers of oxidative stress, and severity of diabetic retinopathy. Diabet. care. 23: 234-240.
16. Litch field JT, Wilcoxon F (1959). Determination of acute toxicity tests. J. Pharmacol. Exp. Ther. 96: 99-113.
17. Mazunder UK, Gupta M, Rajeshwar Y (2005). Antihyperglycaemic effect and antioxidant potential of Phyllantus niruri (Euphorbiaceae) in streptozotocin induced diabetic rats. Eur. Bull. Drug Res. 13 (1): 15-23.
18. McCord JM, Keele BB, Fridovich I Jr. (1976). An enzyme based theory of obligate anaerobiosis. The physiological functions of superoxide dismutase. Proc. Natl. Acad. Sci. USA. 68: 1024-1027.
19. Meneghini R (1988). Genotoxicity of active oxygen species in mammalian cells. Mutat. Res. 195:215-230.
20. Murali B, Upadhyaya UM, Goyal RK (2002). Effect of chronic treatment with Enicostemma littorate in non-insulin dependent diabetic (NIDDM) rats. J. Ethnopharmacol. 81:199-204.
21. Nichans WG, Sannelson D (1968). Formation of malondialdehyde from phospholipids arachidonate during microsomal lipid peroxidation. Eur. J. Biochem 6:126-130.
22. Nwanjo HU (2005). Efficacy of aqueous leaf extract of Vernonia amygdalina on plasma lipoprotein and oxidative status in diabetic rat models. Nig. J. Physiol. Sci. 20(1&2): 39-42.
23. Nwanjo HU, Ojiako OA (2005). Changes in Plasma Electrolytes and Lipoproteins in Hypertensives on Hydrothiazide Therapy. Nig. J. Biochem. Mol. Biol. 20(1): 31-33.
24. Omaye ST, Turbull TP, Sanberchich HC (1979). Selected methods for determination of ascorbic acid in cells, tissues and fluids. Methods, Enzymol. 6:3-11.
25. Ozsoy-Sacan O (2000). Effects of chard (Beta vulgaris L. varcicla) extract on pancreatic β-cells in STZ-diabetic rats: morphological and biochemical study. J. ethnopharmacol. 73: 251-259.
26. Pari l, Amadi RD (2005). Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. J. Pharm. Pharmaceut. Sci. 8(1): 115-123.
27. Rakieten N, Rakieten ML, Nadkarni MV (1963). Studies on the diabetogenic action of streptozotocin. Cancer Chemother. Rep. 29: 91-98.
28. Reiter, R.J. (1995). Oxidative processes and antioxidative defuse mechanisms in the aging brain. FASEB, 9: 526-533.
29. Scoppola A, Montecchi FR, Meqinger G, Lala A (2001). Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. Atherosclerosis. 156: 357-36.
30. Sinha KA (1972). Colorimetric assay of catalase. Ann. Biochem. 47: 389-394
31. nd Edition. Sage Press Inc Nig. pp 34.
32. Uchimura K, Nagasaka A, Hayashi R, Makino M, Nagata M, Kakizawa H, Kobayashi T, Fujiwara K, Kato T, Iwase K, Shinohara R, Kato K, Itoh M (1999). Changes in suproxide dismutase activities and myoloperioxdase activities in leukocytes from patients with diabetes mellitus. J. Diabetes complications 13: 264-270.
33. Viani P, Cervato G, Fiorilli A, Cestaro B (1991). Age related difference in synapatozomal peroxidative damage and membrane properties. J. Neurochem 15: 253-258.