Using disaccharides to enhance in vitro and in vivo transgene expression mediated by a lipid-based gene delivery system

Journal of Gene Medicine

Volumn 9, Issue 8, 2007, Pages 659-667

  Tseng, Wen Chi ^a   Tang, Chien Hsiang ^a   Fang, Tsuei Yun ^b   Su, Ling Yu ^a  

^a NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

Author keywords

Cellobiose; Disaccharide; Intravenous; Liposomes; Transfection; Trehalose

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; AZIDE; CELLOBIOSE; CHOLESTEROL; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DISACCHARIDE; ETHIDIUM; GREEN FLUORESCENT PROTEIN; MALTOSE; PLASMID DNA; PLASMID VECTOR; PROTAMINE; TREHALOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHO CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; EXPRESSION VECTOR; FEMALE; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; LIPOSOMAL GENE DELIVERY SYSTEM; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; TRANSGENE;

ANIMALS; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; DISACCHARIDES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LIPIDS; LIPOSOMES; LUCIFERASES; MICE; PLASMIDS; TRANSFECTION; TRANSGENES;

EID: 34548066266     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1063     Document Type: Article

References (21)

1. Li S, Huang L. Nonviral gene therapy: promises and challenges. Gene Ther 2000; 7: 31-34.
2. Nishikawa M, Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 2001; 12: 861-870.
3. Kostarelos K, Miller AD What role can chemistry play in cationic liposome-based gene therapy research today? In Non-viral vectors for gene therapy Huang L, Hung MC, Wagner E (eds). Elsevier Academic Press: San Diego, 2005; 71-118.
4. Felgner PL, Gadek TR, Holm M, et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci U S A 1987; 84: 7413-7417.
5. Behr JP, Demeneix B, Loeffler JP, Perez-Mutul J. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc Natl Acad Sci U S A 1989; 86: 6982-6986.
6. Felgner JH, Kumar R, Sridhar CN, et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem 1994; 269: 2550-2561.
7. Stephan DJ, Yang ZY, San H, et al. A new cationic hposome DNA complex enhances the efficiency of arterial gene transfer in vivo. Hum Gene Ther 1996; 7: 1803-1812.
8. Gao X, Huang L. A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Commun 1991; 179: 280-285.
9. Vigneron JP, Oudrhiri N, Fauquet M, et al. Guanidinium-cholesterol cationic lipids: efficient vectors for the transfection of eukaryotic cells. Proc Natl Acad Sci U S A 1996; 93: 9682-9686.
10. Sorgi FL, Bhattacharya S, Huang L. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther 1997; 4: 961-968.
11. Gao X, Huang L. Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry 1996; 35: 1027-1036.
12. Fritz JD, Herweijer H, Zhang G, Wolff JA. Gene transfer into mammalian cells using histone-condensed plasmid DNA. Hum Gene Ther 1996; 7: 1395-1404.
13. Tagawa T, Manvell M, Brown N, et al. Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA. Gene Ther 2002; 9: 564-576.
14. Li B, Li S, Tan Y, et al. Lyophilization of cationic lipid-protamine-DNA (LPD) complexes. J Pharmaceut Sci 2000; 89: 355-364.
15. Tseng WC, Tang CH, Fang TY The role of dextran conjugation in transfection mediated by dextran-grafted polyethylenimine. J Gene Med 2004; 6: 895-905.
16. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
17. Ogris M, Steinlein P, Kursa M, Mechtler K, Kircheis R, Wagner E. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther 1998; 5: 1425-1433.
18. Abbott PJ, Chen J. WHO food additives series 46: trehalose. The international Programme on Chemical Safety: Geneva, Switzerland, 2000.
19. Matsuo T, Tsuchida Y, Morimoto N. Trehalose eye drops in the treatment of dry eye syndrome. Ophthalmology 2002; 109: 2024-2029.
20. Katsuno M, Adachi H, and Sobue G. Sweet relief for Huntington disease. Nat Med 2004; 10: 123-124.
21. Tanaka M, Machida Y, Niu S, et al. Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat Med 2004; 10: 148-154.