Determination of emtricitabine in human plasma using HPLC with fluorometric detection

Journal of Liquid Chromatography and Related Technologies

Volumn 30, Issue 18, 2007, Pages 2769-2778

  Droste, J A H ^a   Aarnoutse, R E ^b   Burger, D M ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

Emtricitabine; FTC; HIV; Non nucleoside reverse transcriptase inhibitor; NRTI

Indexed keywords

FLUOROMETERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHOSPHATES; VIRUSES;

EMTRICITABINE; FTC; HIV; NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS; NRTI;

PLASMA (HUMAN);

ANTIRETROVIRUS AGENT; EMTRICITABINE; METHANOL; PHOSPHATE;

ACCURACY; ANALYTICAL EQUIPMENT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MONITORING; ELUTION; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; PLASMA; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; VALIDATION STUDY;

EID: 34548063775     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070701560900     Document Type: Article

References (9)

1. EMEA. Emtriva; Summary of Product Characteristics. 2006.
2. Gallant, J.E.; DeJesus, E.; Arribas, J.R.; Pozniak, A.L.; Gazzard, B.; Campo, R.E.; Lu, B.; McColl, D.; Chuck, S.; Enejosa, J.; Toole, J.J.; Cheng, A.K.; Tenofovir, DF. Emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV. N. Engl. J. Med. 2006, 354 (3), 251-360.
3. Working Group of the Office of AIDS Research Advisory Council (OARAC), Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents, version October 10, 2006, 6 A.D.
4. Rezk, N.L.; Crutchley, R.D.; Kashuba, A.D. Simultaneous quantification of emtricitabine and tenofovir in human plasma using high performance liquid chromatography after solid phase extraction. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 822 (1-2), 201-208.
5. Notari, S.; Bocedi, A.; Ippolito, G.; Narciso, P.; Pucillo, L.P.; Tossini, G.; Donnorsdo, R.P.; Gasparrini, F.; Ascenzi, P. Simultaneous determination of 16 anti-HIV drugs in human plasma by high performance liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006, 831 (1-2), 258-266.
6. Gish, R.G.; Leung, N.W.; Wright, T.L.; Trinh, H.; Lang, W.; Kessler, H.A.; Fang, L.; Wang, L.H.; Delehanty, J.; Rigney, E.; Mondou, E.; Snow, A.; Rousseau, F. Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection. Antimicrob. Agents Chemother. 2002, 46 (6), 1734-1740.
7. Anonymous. Guidance for Industry Bioanalytical Method Validation. 2001.
8. Holland, D.T.; Difrancesco, R.; Stone, J.; Hamzeh, F.; Connor, J.D.; Morse, G.D. Quality assurance program for clinical measurement of antiretrovirals: AIDS clinical trials group proficiency testing program for pediatric and adult pharmacology laboratories. Antimicrob. Agents Chemother. 2004, 48 (3), 824-831.
9. Snyder, L.R.; Kirkland, J.J.; Glaajch, J.L. Practical HPLC Method Development, 2nd Ed.; Wiley: New York, 1997, Ch 7.