Influence of loxoprofen use on recovery from naturally acquired upper respiratory tract infections: A randomized controlled trial

Internal Medicine

Volumn 46, Issue 15, 2007, Pages 1179-1185

  Goto, Masashi ^a   Kawamura, Takashi ^a   Shimbo, Takuro ^b   Takahashi, Osamu ^c   Ando, Masahiko ^a   Miyaki, Koichi ^d   Nohara, Takahiko ^e   Watanabe, Hidetsuna ^f   Suzuki, Isamu ^g   Aono, Mitsuru ^a   Matsui, Kunihiko ^h   Shimokata, Kaoru ⁱ   Fukui, Tsuguya ^j   Saeki, Shuichi ^k   Nagano, Jun ^l   Miyake, Shuji ^m   Ohsawa, Isao ⁱ   Sakamoto, Hirokazu ⁿ   Iida, Norihiko ^o   Mabuchi, Shigeki ^p   Nomura, Hideki ^q   Tasaka, Yoshikazu ^r   Suzuki, Yoshimitsu ^s   Kamei, Mitsuhiro ^t   Kikawa, Kazuhiko ^h   Matsubara, Hidetoshi ^u   Takahashi, Yuko ^v   Yamaguchi, Yukihiro ^w   Yamada, Takuji ^x   Fukumoto, Yohei ^y   more..

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^c KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e SHIMANE UNIVERSITY   (Japan)

^f FUKUSHIMA UNIVERSITY   (Japan)

^g MURORAN INSTITUTE OF TECHNOLOGY   (Japan)

^h KUMAMOTO UNIVERSITY   (Japan)

ⁱ NAGOYA UNIVERSITY   (Japan)

^j ST LUKE'S INTERNATIONAL HOSPITAL   (Japan)

^k EHIME UNIVERSITY   (Japan)

^l KYUSHU UNIVERSITY   (Japan)

^m TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

ⁿ Hyogo Prefectural Kakogawa Hospital   (Japan)

^o KANSAI UNIVERSITY   (Japan)

^p Hongo Clinic

^q KANAZAWA UNIVERSITY   (Japan)

^r Tasaka Clinic

^s Suzuki Clinic

^t Kamei Clinic   (Japan)

^u SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^v NARA WOMEN'S UNIVERSITY   (Japan)

^w Kenwakai Ohtemachi Hospital

^x Sakae Clinic

^y YAMAGUCHI UNIVERSITY   (Japan)

more..

Author keywords

Commosn cold; Loxoprofen; Non steroidal anti inflammatory agents

Indexed keywords

ANTIHISTAMINIC AGENT; ANTITUSSIVE AGENT; LOXOPROFEN; MEQUITAZINE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO; PHENYLPROPIONIC ACID DERIVATIVE;

ADULT; ARTHRALGIA; ARTICLE; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DAILY LIFE ACTIVITY; DISEASE DURATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; FEVER; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALAISE; MALE; MULTICENTER STUDY; MYALGIA; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SYMPTOMATOLOGY; THIRST; UPPER RESPIRATORY TRACT INFECTION; ADOLESCENT; AGED; HOSPITALIZATION; MIDDLE AGED; RESPIRATORY TRACT INFECTION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENYLPROPIONATES; RESPIRATORY TRACT INFECTIONS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 34548062906     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.46.6334     Document Type: Article

References (17)

1. Turner RB. Epidemiology, pathogenesis, and treatment of the common cold. Ann Allergy Asthma Immumol 78: 531-540, 1997.
2. Kirkpatrick GL. The common cold. Prim Care 23: 657-675, 1996.
3. Graham NMH, Burrell CJ, Douglas RM, Debelle P, Davies L. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers. J Infect Dis 162: 1277-1282, 1990.
4. Stanley ED, Jackson GG, Panusarn C, Rubenis M, Dirda V. Increased virus shedding with aspirin treatment of rhinovirus infection. JAMA 231: 1248-1251, 1975.
5. Mogabgab WJ, Pollock B. Letter: increased virus shedding with aspirin treatment of rhinovirus infection. JAMA 235: 801, 1976.
6. Hsia J, Simon GL, Higgins N, Goldstein AL, Hayden FG. Immune modulation by aspirin during experimental rhinovirus colds. Bull N Y Acad Med 65: 45-56, 1989.
7. Sperber SJ, Sorrentino JV, Riker DK, Hayden FG. Evaluation of an alpha agonist alone and in combination with a nonsteroidal anti-inflammatory agent in the treatment of experimental rhinovirus colds. Bull N Y Acad Med 65: 145-160, 1989.
8. Sperber SJ, Hendley JO, Hayden FG, Riker DK, Sorrentino JV, Gwaltney JM Jr. Effects of naproxen on experimental rhinovirus colds: a randomized, double-blind, controlled trial. Ann Intern Med 117: 37-41, 1992.
9. Ebel DL, Shib WJ, Rhymer AR. A multi-center, double-blind randomized study to assess the efficacy and tolerance of sulindac versus placebo in the symptomatic treatment of patients with upper respiratory tract infection. Curr Med Res Opin 9: 666-675, 1985.
10. Martinez Gallardo F, Lopez Fiesco A, Zamora G. Symptomatic treatment of common cold in children with a new combination of naproxen sodium plus pseudoephedrine hydrochloride: a comparative trial against pseudoephedrine syrup. Proc West Pharmacol Soc 37: 157-158, 1994.
11. Winther B, Mygind N. The therapeutic effectiveness of ibuprofen on the symptoms of naturally acquired common colds. Am J Rhinol 15: 239-242, 2001.
12. Eccles R, Loose I, Jawad M, Nyman L. Effects of acetylsalicylic acid on sore throat pain and other pain symptoms associated with acute upper respiratory tract infection. Pain Med 4: 118-124, 2003.
13. Brunton LL, Lazo JS, Parker KL, Goodman LS, Gilman AG. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11th ed. McGraw-Hill, New York, 671-706, 2005.
14. Kramer MS, Naimark LE, Roberts-Brauer R, McDougall A, Leduc DG. Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin. Lancet 337: 591-594, 1991.
15. Jackson GG, Dowling BF, Spiesman IG, Boand AV. Transmission of the common cold to volunteers under controlled conditions: the common cold as a clinical entity. Arch Intern Med 101: 267-278, 1958.
16. Ware JH, Fitzmaurice GM, Laird NM. Applied longitudinal analysis. Wiley-Interscience, NJ 2004.
17. Katsu M, Matsuoka Y, Irimajiri S, et al. Clinical evaluation of loxoprofen sodium (CS-600E) on upper respiratory tract inflammation: a double-blind controlled study in comparison with ibuprofen. Rinsho Iyaku 9: 2299-2320, 1993 (in Japanese).