Studies on absorption of paeoniflorin in rat small intestines by HPLC-MS

Chinese Pharmaceutical Journal

Volumn 42, Issue 14, 2007, Pages

  Shui, Wen Bo ^a   He, Qing ^a   Ge, Zhi Wei ^a   Cheng, Yi Yu ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

HPLC MS; Paeoniflorin; Small intestine absorption

Indexed keywords

GLYCOPROTEIN P INHIBITOR; PAEONIFLORIN; POLYSORBATE 80; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG METABOLISM; DRUG PENETRATION; DRUG TISSUE LEVEL; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE ABSORPTION; MASS SPECTROMETRY; NONHUMAN; RAT; SMALL INTESTINE;

EID: 34548056490     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. CHEN J H, CHEN J. A study of feature of phenylpropanolamine absorption in intestine [J]. Chin J Hosp Pharm, 2000,20(2):3-75.
2. WAGNER D, SPAHN-LANGGNTH H, HANAFY A, et al. Intestinal drug effluxformulation and food effects [J]. Adv Drug Deliv Rev, 2001,50(Suppl 1):13-31.
3. LIANG J, ZHOU A, CHEN M, et al. Negatively regulatory effects of paeoniflorin on immune cells [J]. Eur J Pharmacol, 1990,189:901-902.
4. OHTA H, MATSUMOTO K, SHIMIZU M, et al. Paeoniflorin attenuates learning impairment of aged rats on operant brightness discrimination task [J]. Pharmacol Biochem Be, 1994,49(1):213-217.
5. WATANABE H. Candidates for cognitive enhancer extracted from medicinal plants, paeoniflorin and tetramethylpyrazine [J]. Behav Brain Res, 1997,83(1-2):135-141.
6. YANG H O, KO W K, KIM J Y, et al. Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora [J]. Fitoterapia, 2004, 75(1):45-49.
7. WILSON T H, WISEMAN G. The use of sacs of everted small intestine for the study of the transference of substances form the mucosal to the serosal surface [J] . J Physiol, 1954,123:116.
8. HE Y X, SUN J, CHENG G. Key role of the multidrug resistance P-glycoprotein in the intestinal absorption of drugs [J]. J Shenyang Pharm Univ, 2004,21(5):389-393.
9. SU C Y. Role of P-glycoprotein in pharmacokinetics and its clinical implications [J] . Acta Pharm Sin, 2005,40(8):673-679.
10. LU X S, LI Y. The joint altion of P-glycoprotein and cytochrome P450 3 A in the drug absorption [J]. Foreign Med Sci Pharm, 2003,31(2):108-111.
11. ZHANG L, ZHENG Y, CHOW M S, et al. Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model [J]. Int J Pharm, 2004,287(1-2):1-12.
12. NOBILIS M, HOLCAPEK M, KOLAROVA L, et al. Identification and determination of phase II nabumetone metabolites by high-performance liquid chromatography with photodiode array and mass spectrometric detection [J]. J Chromatogr A, 2004,1031(1-2):229-236.