Bone Alterations in Children and Young Adults With Renal Transplant Assessed by Phalangeal Quantitative Ultrasound

American Journal of Kidney Diseases

Volumn 50, Issue 3, 2007, Pages 441-449

  Mussa, Alessandro ^a   Porta, Francesco ^b   Gianoglio, Bruno ^a   Gaido, Maurizio ^a   Nicolosi, Mario Guido ^c   De Terlizzi, Francesca ^d   de Sanctis, Carlo ^a   Coppo, Rosanna ^a  

^a REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c S ANNA HOSPITAL   (Italy)

^d IGEA Biophysics Laboratory   (Italy)

Author keywords

Bone; bone density; kidney transplantation; quantitative ultrasound; renal osteodystrophy

Indexed keywords

ALFACALCIDOL; AZATHIOPRINE; CALCIUM; CALCIUM CARBONATE; CYCLOSPORIN A; GLUCOCORTICOID; HUMAN GROWTH HORMONE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PARATHYROID HORMONE; PHOSPHATE;

ADULT; AMPLITUDE MODULATION; ARTICLE; BODY MASS; BONE AGE; BONE DENSITY; BONE STRUCTURE; CALCIUM BLOOD LEVEL; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE ASSOCIATION; ECHOGRAPHY; FEMALE; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HUMAN; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; MULTIVARIATE ANALYSIS; PARATHYROID HORMONE BLOOD LEVEL; PHALANX; PHOSPHATE BLOOD LEVEL; RENAL OSTEODYSTROPHY; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; BONE DISEASES; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; FINGER PHALANGES; HUMANS; KIDNEY TRANSPLANTATION; MALE;

EID: 34548044014     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2007.06.002     Document Type: Article

References (55)

1. NIH Consensus Development Panel on Osteoporosis Prevention Diagnosis and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 285 (2001) 785-795
2. Saggese G., Baroncelli G.I., and Bertelloni S. Osteoporosis in children and adolescents: Diagnosis, risk factors, and prevention. J Pediatr Endocrinol Metab 14 (2001) 833-859
3. Sprague S.M. Mechanism of transplantation-associated bone loss. Pediatr Nephrol 14 (2000) 650-653
4. Grotz W.H., Mundinger F.A., Rasenack J., et al. Bone loss after kidney transplantation: A longitudinal study in 115 graft recipients. Nephrol Dial Transplant 10 (1995) 2096-2100
5. Saland J.M., Goode M.L., Haas D.L., et al. The prevalence of osteopenia in pediatric renal allograft recipients varies with the method of analysis. Am J Transplant 1 (2001) 243-250
6. Daniels M.W., Wilson D.M., Paguntalan H.G., et al. Bone mineral density in pediatric transplant recipients. Transplantation 76 (2003) 673-678
7. Ellis E.N., Floyd-Gimon D.M., Berry P.L., et al. Risk factors for bone mineral density loss in pediatric renal transplant patients. Pediatr Transplant 4 (2000) 146-150
8. el-Husseini A.A., el-Agroudy A.E., Wafa E.W., et al. Bone mineral density in live related kidney transplant children and adolescents. Int Urol Nephrol 36 (2004) 95-100
9. van Rijn R.R., van der Sluis I.M., Link T.M., et al. Bone densitometry in children: A critical appraisal. Eur Radiol 13 (2003) 700-710
10. Gafni R.I., and Baron J. Overdiagnosis of osteoporosis in children due to misinterpretation of dual-energy x-ray absorptiometry (DEXA). J Pediatr 144 (2004) 253-257
11. Goksen D., Darcan S., Kara P., et al. Bone mineral density in pediatric and adolescent renal transplant patients: How to evaluate. Pediatr Transplant 9 (2005) 464-469
12. Leonard M.B. Assessment of bone mass following renal transplantation in children. Pediatr Nephrol 20 (2005) 360-367
13. Reusz G.S., Szabo A.J., Peter F., et al. Bone metabolism and mineral density following renal transplantation. Arch Dis Child 83 (2000) 146-151
14. Klaus G., Paschen C., Wuster C., et al. Weight-/height-related bone mineral density is not reduced after renal transplantation. Pediatr Nephrol 12 (1998) 343-348
15. Wren T.A., Liu X., Pitukcheewanont P., et al. Bone acquisition in healthy children and adolescents: Comparisons of dual-energy x-ray absorptiometry and computed tomography measures. J Clin Endocrinol Metab 90 (2005) 1925-1928
16. Cavani F., Fini M., de Terlizzi F., et al. Effect of trabecular orientation on mechanical resistance and ultrasound propagation in specimens of equine vertebrae. Ultrasound Med Biol 29 (2003) 1777-1785
17. de Terlizzi F., Battista S., Cavani F., et al. Influence of bone tissue density and elasticity on ultrasound propagation: An in vitro study. J Bone Miner Res 15 (2000) 2458-2466
18. Barkmann R., Lusse S., Stampa B., et al. Assessment of the geometry of human finger phalanges using quantitative ultrasound in vivo. Osteoporos Int 11 (2000) 745-755
19. Sakata S., Barkmann R., Lochmuller E.M., et al. Assessing bone status beyond BMD: Evaluation of bone geometry and porosity by quantitative ultrasound of human finger phalanges. J Bone Miner Res 19 (2004) 924-930
20. Dalle Carbonare L., and Giannini S. Bone microarchitecture as an important determinant of bone strength. J Endocrinol Invest 27 (2004) 99-105
21. Gluer C.C., and The International Quantitative Ultrasound Consensus Group. Quantitative ultrasound techniques for the assessment of osteoporosis: Expert agreement on current status. J Bone Miner Res 12 (1997) 1280-1288
22. Bauer D.C., Gluer C.C., Cauley J.A., et al., Study of Osteoporotic Fractures Research Group. Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med 157 (1997) 629-634
23. Baroncelli G.I., Federico G., Bertelloni S., et al. Assessment of bone quality by quantitative ultrasound of proximal phalanges of the hand and fracture rate in children and adolescents with bone and mineral disorders. Pediatr Res 54 (2003) 125-136
24. Schalamon J., Singer G., Schwantzer G., et al. Quantitative ultrasound assessment in children with fractures. J Bone Miner Res 19 (2004) 1276-1279
25. Cacciari E., Milani S., Balsamo A., et al. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest 29 (2006) 581-593
26. Tanner J.M., and Whitehouse R.H. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 51 (1976) 170-179
27. Baroncelli G.I., Federico G., Vignolo M., et al. Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone 39 (2006) 159-173
28. Wuster C., Albanese C., De Aloysio D., et al., The Phalangeal Osteosonogrammetry Study Group. Phalangeal osteosonogrammetry study: Age-related changes, diagnostic sensitivity, and discrimination power. J Bone Miner Res 15 (2000) 1603-1614
29. Montagnani A., Gonnelli S., Cepollaro C., et al. Quantitative ultrasound at the phalanges in healthy Italian men. Osteoporos Int 11 (2000) 499-504
30. Landin L.A. Fracture patterns in children. Analysis of 8,682 fractures with special reference to incidence, etiology and secular changes in a Swedish urban population 1950-1979. Acta Orthop Scand Suppl 202 (1983) S1-S109
31. Mentzel H.J., John U., Boettcher J., et al. Evaluation of bone-mineral density by digital x-ray radiogrammetry (DXR) in pediatric renal transplant recipients. Pediatr Radiol 35 (2005) 489-494
32. Negri A.L., Lombas C., Cuevas C., et al. Evaluation of cortical bone by peripheral quantitative computed tomography in renal transplant recipients. Transplant Proc 37 (2005) 1020-1022
33. Ruth E.M., Weber L.T., Schoenau E., et al. Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients. Kidney Int 66 (2004) 1694-1706
34. Sanchez C.P., Salusky I.B., Kuizon B.D., et al. Bone disease in children and adolescents undergoing successful renal transplantation. Kidney Int 53 (1998) 1358-1364
35. Montagnani A., Gonnelli S., Cepollaro C., et al. Graphic trace analysis of ultrasound at the phalanges may differentiate between subjects with primary hyperparathyroidism and with osteoporosis: A pilot study. Osteoporos Int 13 (2002) 222-227
36. Roe S.D., Porter C.J., Godber I.M., et al. Reduced bone mineral density in male renal transplant recipients: Evidence for persisting hyperparathyroidism. Osteoporos Int 16 (2005) 142-148
37. Behnke B., Altrogge H., Delling G., et al. Bone mineral density in pediatric patients after renal transplantation. Clin Nephrol 46 (1996) 24-29
38. Duan Y., De Luca V., and Seeman E. Parathyroid hormone deficiency and excess: Similar effects on trabecular bone but differing effects on cortical bone. J Clin Endocrinol Metab 84 (1999) 718-722
39. Feber J., Cochat P., and Braillon P. Bone mineral density in children after renal transplantation. Pediatr Nephrol 14 (2000) 654-657
40. Casez J.P., Lippuner K., Horber F.F., et al. Changes in bone mineral density over 18 months following kidney transplantation: The respective roles of prednisone and parathyroid hormone. Nephrol Dial Transplant 17 (2002) 1318-1326
41. Moreno A., Torregrosa J.V., Pons F., et al. Bone mineral density after renal transplantation: Long-term follow-up. Transplant Proc 31 (1999) 2322-2323
42. Boot A.M., Nauta J., Hokken-Koelega A.C., et al. Renal transplantation and osteoporosis. Arch Dis Child 72 (1995) 502-506
43. Reid I.R. Glucocorticoid-induced osteoporosis. Baillieres Best Pract Res Clin Endocrinol Metab 14 (2000) 279-298
44. Lukert B.P., and Raisz L.G. Glucocorticoid-induced osteoporosis: Pathogenesis and management. Ann Intern Med 112 (1990) 352-364
45. Vedi S., Elkin S.L., and Compston J.E. A histomorphometric study of cortical bone of the iliac crest in patients treated with glucocorticoids. Calcif Tissue Int 77 (2005) 79-83
46. Dalle Carbonare L., Arlot M.E., Chavassieux P.M., et al. Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis. J Bone Miner Res 16 (2001) 97-103
47. Wuster C., Heilmann P., Pereira-Lima J., et al. Quantitative ultrasonometry (QUS) for the evaluation of osteoporosis risk: Reference data for various measurement sites, limitations and application possibilities. Exp Clin Endocrinol Diabetes 106 (1998) 277-288
48. van Staa T.P., Cooper C., Leufkens H.G., et al. Children and the risk of fractures caused by oral corticosteroids. J Bone Miner Res 18 (2003) 913-918
49. del Pozo E., Lippuner K., Ruch W., et al. Different effects of cyclosporin A on bone remodeling in young and adult rats. Bone 16 suppl 4 (1995) 271S-275S
50. Movsowitz C., Epstein S., Ismail F., et al. Cyclosporin A in the oophorectomized rat: Unexpected severe bone resorption. J Bone Miner Res 4 (1989) 393-398
51. Cvetkovic M., Mann G.N., Romero D.F., et al. The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. Transplantation 57 (1994) 1231-1237
52. Goffin E., Devogelaer J.P., Lalaoui A., et al. Tacrolimus and low-dose steroid immunosuppression preserves bone mass after renal transplantation. Transpl Int 15 (2002) 73-80
53. Grotz W., Mundinger A., Gugel B., et al. Missing impact of cyclosporine on osteoporosis in renal transplant recipients. Transplant Proc 26 (1994) 2652-2653
54. Klein L., Lemel M.S., Wolfe M.S., et al. Cyclosporin A does not affect the absolute rate of cortical bone resorption at the organ level in the growing rat. Calcif Tissue Int 55 (1994) 295-301
55. Abdelhadi M., Ericzon B.G., Hultenby K., et al. Structural skeletal impairment induced by immunosuppressive therapy in rats: Cyclosporine A vs tacrolimus. Transpl Int 15 (2002) 180-187