Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 8, 2007, Pages 1395-1399

  Son, Eui Dong ^a   Choi, Gyu Ho ^b   Kim, Hyaekyoung ^a   Lee, Byoungseok ^a   Chang, Ih Seoup ^a   Hwang, Jae Sung ^a  

^a AmorePacific Corporation   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

Author keywords

ketoglutarate; Anti wrinkle; Procollagen; Prolidase; Prolidase inhibitor; Prolyl 4 hydroxylase

Indexed keywords

2 OXOGLUTARIC ACID; ALCOHOL; ENZYME INHIBITOR; N BENZYLOXYCARBONYL LEVO PROLINE; PROCOLLAGEN; PROLINE DIPEPTIDASE; PROPYLENE GLYCOL; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; COLLAGEN METABOLISM; COLLAGEN SYNTHESIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HAIRLESS MOUSE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SKIN FIBROBLAST; ULTRAVIOLET B RADIATION; WRINKLE;

ADMINISTRATION, TOPICAL; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; COLLAGEN TYPE I; DIPEPTIDASES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KETOGLUTARIC ACIDS; MICE; MICE, INBRED HRS; PROCOLLAGEN; PROLINE; SKIN; SKIN AGING; STIMULATION, CHEMICAL; TETRAZOLIUM SALTS; THIAZOLES; ULTRAVIOLET RAYS;

EID: 34548022880     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.1395     Document Type: Article

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