Quantitation of urinary glycosaminoglycans using dimethylene blue as a screening technique for the diagnosis of mucopolysaccharidoses - An evaluation

Annals of Clinical Biochemistry

Volumn 44, Issue 4, 2007, Pages 360-363

  Gray, George ^a   Claridge, Paul ^a   Jenkinson, Linda ^a   Green, Anne ^a  

^a BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLENE BLUE; DYE; GLYCOSAMINOGLYCAN; DIAGNOSTIC AGENT; DIMETHYLMETHYLENE BLUE; DRUG DERIVATIVE; METHYLENE BLUE; UNCLASSIFIED DRUG;

ABNORMAL LABORATORY RESULT; ADOLESCENT; ADULT; ANALYTIC METHOD; ARTICLE; AUTOANALYSIS; AUTOANALYZER; CHILD; DIAGNOSTIC VALUE; HUMAN; INFANT; LABORATORY TEST; MAJOR CLINICAL STUDY; METABOLIC DISORDER; MUCOPOLYSACCHARIDOSIS; NEWBORN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCREENING TEST; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; URINALYSIS; URINE LEVEL; COLORIMETRY; ELECTROPHORESIS; EVALUATION; MASS SCREENING; MIDDLE AGED; PRESCHOOL CHILD; URINE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; COLORIMETRY; ELECTROPHORESIS, CELLULOSE ACETATE; GLYCOSAMINOGLYCANS; HUMANS; INFANT; INFANT, NEWBORN; MASS SCREENING; METHYLENE BLUE; MIDDLE AGED; MUCOPOLYSACCHARIDOSES;

EID: 34548017456     PISSN: 00045632     EISSN: 00045632     Source Type: Journal    
DOI: 10.1258/000456307780945688     Document Type: Article

References (9)

1. Brimble B, Pennock C, Stone J. Results of a quality assurance exercise for urinary glycosaminoglycan excretion. Ann Clin Biochem 1990; 27: 133-8
2. Whitley CB, Ridnour MD, Draper CMD, Dutton CM, Neglia JP. Diagnostic test for mucopolysaccharidosis. I. Direct method for quantifying excessive urinary glycosaminoglycan excretion. Clin Chem 1989; 35: 374-9
3. de Jong JGN, Wevers RA, Laarakkers C, Poorthuis JHM. Dimethylene blue-based spectrophotometry of glycosaminoglycans in untreated urine: a rapid screening procedure for mucopolysaccharidoses. Clin Chem 1989; 35: 1472-7
4. de Jong JGN, Wevers RA, Liebrand-van Sambeek R. Measuring urinary glycosaminoglycans in the presence of protein: an improved screening procedure for mucopolysaccharidoses based on dimethylene blue. Clin Chem 1992; 38: 803-7
5. Whiteman P. Acid glycosaminoglycan excretion in the mucopolysaccharidoses. Determination of glycosaminoglycans in urine and amniotic fluid using new microanalytical techniques. In: Holton JB, Ireland JT, eds. Inborn Errors of Skin, Hair and Connective Tissue. Baltimore: University Park Press, 1975: 251-65
6. Colville GA, Bax MA. Early presentation in the mucopolysaccharidosis disorders. Child Care Health Dev 1996; 22: 31-6
7. Cleary MA, Green A. Developmental delay: when to suspect and how to investigate for an inborn error of metabolism. Arch Dis Child 2005; 90: 1128-32
8. Stone JE, Akhtar N, Botchway S, Pennock CA. Interaction of 1,9-dimethylene blue with glycosaminoglycans. Ann Clin Biochem 1994; 31: 147-52
9. Clements P. Mass spectrometry as a platform for the diagnosis of lysosomal disorders. Clin Chem 2004; 50: 1723-4