Dietary arachidonic acid: Harmful, harmless or helpful?

British Journal of Nutrition

Volumn 98, Issue 3, 2007, Pages 451-453

  Calder, Philip C ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME P450; DOCOSAHEXAENOIC ACID; HYDROXYICOSATETRAENOIC ACID; ICOSAPENTAENOIC ACID; LEUKOTRIENE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LINOLEIC ACID; LIPOXIN; LIPOXYGENASE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHOLIPASE; PROSTACYCLIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; STEROID; THROMBOXANE; THROMBOXANE A2;

DRUG DOSE INCREASE; DRUG EFFICACY; DRUG TARGETING; ENZYME SUBSTRATE; FAT INTAKE; FATTY ACID SYNTHESIS; FOOD INTAKE; HUMAN; IMMUNE DEFICIENCY; INFLAMMATION; LIPID COMPOSITION; NOTE; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; THROMBOSIS; VITAMIN SUPPLEMENTATION;

ADULT; ARACHIDONIC ACID; CELL MEMBRANE; DIET; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; PHOSPHOLIPIDS; PLATELET AGGREGATION; TRIGLYCERIDES;

EID: 34547967990     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507761779     Document Type: Note

References (32)

1. von Schacky C, Fischer S & Weber PC (1985) Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. J Clin Invest 76 1626-1631.
2. Yaqoob P, Pala HS, Cortina-Borja M, Newsholme EA & Calder PC (2000) Encapsulated fish oil enriched in alpha-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. Eur J Clin Invest 30, 260-274.
3. Healy DA, Wallace FA, Miles EA, Calder PC & Newsholme P (2000) Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. Lipids 35, 763-768.
4. Harris WS, Sands SA, Windsor SL, Ali HA, Stevens TL, Magalski A, Porter CB & Borkon AM (2004) Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation. Circulation 110, 1645-1649.
5. Elizondo A, Araya J, Rodrigo R, et al. (2007) Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients. Obesity 15, 24-31.
6. Pan DA, Lillioja S, Milner MR, Kriketos AD, Baur LA, Bogardus C & Storlien LH (1995) Skeletal muscle membrane lipid composition is related to adiposity and insulin action. J Clin Invest 96 2802-2808.
7. Sinclair AJ & O'Dea K (1993) The significance of arachidonic acid in hunter-gatherer diets: Implications for the contemporary Western diet. J Food Lipids 1, 142-157.
8. Jonnalagadda SS, Egan SK, Heimbach JT, Harris SS & Kris-Etherton PM (1995) Fatty acid consumption patterns of Americans: 1987-1988 USDA Nationwide Food Consumption Survey. Nutr Res 15, 1767-1781.
9. Mann NJ, Johnson LG, Warrick GE & Sinclair AJ (1995) The arachidonic acid content of the Australian diet is lower than previously estimated. J Nutr 125, 2528-2535.
10. Seyberth HW, Oelz O, Kennedy T, Sweetman BJ, Danon A, Frolich JC, Heimberg M & Oates JA (1975) Increased arachidonate in lipids after administration to man: Effects on prostaglandin biosynthesis. Clin Pharmacol Ther 18, 521-529.
11. Kusumoto A, Ishikura, Y, Kawashima H, Kiso Y, Takai S & Miyazaki M (2007) Effects of arachidonate-enriched triacylglycerol supplementation on serum fatty acids and platelet aggregation in healthy male subjects with a fish diet. Brit J Nutr. Published online: 20 April 2007. doi:10.1017/S0007114507734566.
12. Nelson GJ, Kelley DS, Emken EA, Phinney SD, Kyle D & Ferretti A (1997) A human dietary arachidonic acid supplementation study conducted in a metabolic research unit: Rationale and design. Lipids 32, 415-420.
13. Nelson GJ, Schmidt PC, Bartolini G, Kelley DS & Kyle D (1997) The effect of dietary arachidonic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 32, 421-425.
14. Nelson GJ, Schmidt PC, Bartolini G, Kelley DS, Phinney SD, Kyle D, Silbermann S & Schaefer EJ (1997) The effect of dietary arachidonic acid on plasma lipoprotein distributions, apoproteins, blood lipid levels, and tissue fatty acid composition in humans. Lipids 32, 427-433.
15. Ferretti A, Nelson GJ, Schmidt PC, Kelley DS, Bartolini G & Flanagan VP (1997) Increased dietary arachidonic acid enhances the synthesis of vasoactive eicosanoids in humans. Lipids 32, 435-439.
16. Kelley DS, Taylor PC, Nelson GJ, Schmidt PC, Mackey BE & Kyle D (1997) Effects of dietary arachidonic acid on human immune response. Lipids 32, 449-456.
17. Kelley DS, Taylor PC, Nelson GJ & Mackey BE (1998) Arachidonic acid supplementation enhances synthesis of eicosanoids without suppressing immune functions in young healthy men. Lipids 33, 125-130.
18. Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA & Calder PC (2001) Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged > 55 y. Am J Clin Nutr 73, 539-548.
19. Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA & Calder PC (2001) Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. J Nutr 131, 1918-1927.
20. Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA & Calder PC (2001) Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids 36, 1183-1193.
21. Dyerberg J & Bang HO (1979) Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet ii 433-435.
22. Calder PC (2001) Polyunsaturated fatty acids, inflammation and immunity. Lipids 36, 1007-1024.
23. Calder PC (2003) N-3 polyunsaturated fatty acids and inflammation: From molecular biology to the clinic. Lipids 38, 343-352.
24. Calder PC (2006) N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83, 1505S-1519S.
25. Levy BD (2005) Lipoxins and lioxin analogs in asthma. Prostagland Leukot Essent Fatty Acids 73, 231-237.
26. Levy BD, Clish CB, Schmidt B, Gronert K & Serhan CN (2001) Lipid mediator class switching during acute inflammation: Signals in resolution. Nat Immunol 2, 612-619.
27. Innis SM (1994) The 1993 Borden Award Lecture: Fatty acid requirements of the newborn. Can J Physiol Pharmacol 72, 1483-1492.
28. Sauezwald TU, Demmelmair H & Koletzko B (2001) Polyunsaturated fatty acid supply with human milk. Lipids 36, 991-996.
29. Koletzko B, Decsi T & Demmelmair H (1996) Arachidonic acid supply and metabolism in human infants born at full term. Lipids 31, 79-83.
30. Makrides M, Neumann M, Simmer K, Pater J & Gibson R (1995) Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet 345, 1463-1468.
31. Field CJ, Thomson CA, Van Aerde JE, Parrott A, Euler A, Lien E & Clandinin MT (2000) Lower proportion of CD45R0 + cells and deficient interleukin-10 production by formula-fed infants, compared with human-fed, is corrected with supplementation of long-chain polyunsaturated fatty acids. J Pediatr Gastroenterol Nutr 31 291-299.
32. Carlson SE, Montalto MB, Ponder DL, Werkman SH & Korones SB (1998) Lower incidence. of necrotizing enterocolitis in infants fed a preterm formula with egg phospholipids. Pediatr Res, 44 491-498.