Development of RP-HPLC assay for determination of total luteolin and apigenin in plasma and its application to pharmacokinetics after single oral dose of Chrysanthemum morifolium extract in rats

Chinese Pharmaceutical Journal

Volumn 42, Issue 5, 2007, Pages

  Pan, Lan Ying ^a   Li, Li Ping ^a   Jiang, Hui Di ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Apigenin; Chrysanthemum morifolium extract; HPLC; Luteolin; Pharmacokinetics

Indexed keywords

ACETIC ACID ETHYL ESTER; APIGENIN; CHRYSANTHEMUM MORIFOLIUM EXTRACT; HYDROCHLORIC ACID; LUTEOLIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CHRYSANTHEMUM; COMPUTER PROGRAM; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; NONHUMAN; PKA; SINGLE DRUG DOSE; SPECTRAL SENSITIVITY; ULTRAVIOLET SPECTROSCOPY;

EID: 34547954932     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. HU L H, CENG Z L. Structure elucidation of a new n-pentyl fructofuranoside in Dendranthema morifolium (Ramat) tzvel [J]. Acta Bot Sin,1997,39(1):85-90.
2. HU R B, JIANG H D, YANG J, et al. Determination of luteolin and luteolin-7-β-D-glucoside in chrysanthemum morfolium ramat. from different collection time by RP-HPLC[J]. J Zhejiang Univ (Med Sci),2004,33(1):29-32.
3. CHAN E C, PANNANGPETCH P, WOODMAN O L. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships[J]. Cardiovasc Pharmacol,2000,35(2):326- 329.
4. LI L P, JIANG H D, WU H H, et al. Simultaneous determination of luteolin and apigenin in dog plasma by RP-HPLC[J]. J Pharm Biomed Anal,37(2005):615-620.
5. LI L P, JIANG H D, WU H H, et al. Pharmacoknetics of active component of Chrysanthemum morfolium extracts and its acid hydrolysate in rabbits[J]. Chin Pharm J,2005, 40(24):1884-1886.