Haplotype analysis can provide improved clinical information than single genotype analysis

Thrombosis Research

Volumn 120, Issue 5, 2007, Pages 779-

  Sandrim, Valeria Cristina ^a   Tanus Santos, Jose Eduardo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

CORONARY ARTERY DISEASE; DATA ANALYSIS SOFTWARE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EXON; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; LETTER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VARIABLE NUMBER OF TANDEM REPEAT;

CORONARY ARTERIOSCLEROSIS; DIABETES MELLITUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TECHNIQUES; GENOTYPE; HAPLOTYPES; HUMANS; INTERNET; MALE; NITRIC OXIDE SYNTHASE TYPE III; RISK FACTORS; SEX FACTORS; SOFTWARE;

EID: 34547947975     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2006.08.013     Document Type: Letter

References (8)

1. Kim I.J., Bae J., Lim S.W., Cha D.H., Cho H.J., Kim S., et al. Influence of endothelial nitric oxide synthase gene polymorphisms (- 786T > C, 4a4b, 894G > T) in Korean patients with coronary artery disease. Thromb Res 12 (2006) 12
2. Crawford D.C., and Nickerson D.A. Definition and clinical importance of haplotypes. Annu Rev Med 56 (2005) 303-320
3. Johnson G.C., Esposito L., Barratt B.J., Smith A.N., Heward J., Di Genova G., et al. Haplotype tagging for the identification of common disease genes. Nat Genet 29 (2001) 233-237
4. Sandrim V.C., de Syllos R.W.C., Lisboa H.R.K., Tres G.S., and Tanus-Santos J.E. Endothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus. Atherosclerosis 189 (2006) 41-46
5. Sandrim V.C., Coelho E.B., Nobre F., Arado G.M., Lanchote V.L., and Tanus-Santos J.E. Susceptible and protective eNOS haplotypes in hypertensive black and white subjects. Atherosclerosis 186 (2006) 428-432
6. Sandrim V.C., Yugar-Toledo J.C., Desta Z., Flockhart D.A., Moreno Jr. H., and Tanus-Santos J.E. Endothelial nitric oxide synthase haplotypes and resistance to antihypertensive drug therapy. Journal of Hypertension 24 (2006) 2393-2397
7. Tanus-Santos J.E., Desai M., and Flockhart D.A. Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics 11 (2001) 719-725
8. Marroni A.S., Metzger I.F., Souza-Costa D.C., Nagassaki S., Sandrim V.C., Correa R.X., et al. Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms. Nitric Oxide 12 (2005) 177-182