Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome [6]

Blood

Volumn 110, Issue 3, 2007, Pages 1077-1079

  Norton, Alice ^b   Fisher, Chris ^b   Liu, Hui ^b   Wen, Qiang ^b   Mundschau, Gina ^b   Fuster, Jose Luis ^b   Hasle, Henrik ^b   Zeller, Bernward ^b   Webb, David K ^b   O'Marcaigh, Aengus ^b   Sorrell, April ^b   Hilden, Joanne ^b   Gamis, Alan ^b   Crispino, John D ^b   Vyas, Paresh ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; JANUS KINASE 3; TRANSCRIPTION FACTOR GATA 1;

C MPL GENE; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; DOWN SYNDROME; GATA1 GENE; GENE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; JAK2 GENE; JAK3 GENE; LETTER; MYELOID LEUKEMIA; MYELOPROLIFERATIVE DISORDER; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 34547946210     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-03-080374     Document Type: Letter

References (9)

1. Zipursky A, Brown E, Christensen H, Sutherland R, Doyle J. Leukemia and/or myeloproliferative syndrome in neonates with Down syndrome. Semin Perinatol. 1997:97-101.
2. Gurbuxani S, Vyas P, Crispino JD. Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood. 2004;103:399-406.
3. Hitzler JK, Zipursky A. Origins of leukaemia in children with Down syndrome. Nat Rev Cancer. 2005;5:11-20.
4. Vyas P, Crispino JD. Molecular insights into Down syndrome-associated leukemia. Curr Opin Pediatr. 2007;19:9-14.
5. Walters DK, Mercher T, Gu TL, et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 2006;10:65-75.
6. Kiyoi H, Yamaji S, Kojima S, Naoe T. JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Leukemia. 2007;21:574-576.
7. Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3:e270.
8. Campbell PJ, Green AR. The myeloproliferative disorders. N Engl J Med. 2006;355:2452-2466.
9. Mundschau G, Gurbuxani S, Gamis AS, Greene ME, Arceci RJ, Crispino JD. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood. 2003;101:4298-4300.