Clinical study of effect of tranexamic acid emulsion on melasma and freckles

Skin Research

Volumn 6, Issue 3, 2007, Pages 309-315

  Kondou, Shigeo ^a   Okada, Yuko ^b   Tomita, Yasushi ^b  

^a YAMAGATA UNIVERSITY HOSPITAL   (Japan)

^b AKITA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Ephelides; Medicinal cosmetics; Melasma; Pigmentation

Indexed keywords

TRANEXAMIC ACID;

ABSENCE OF SIDE EFFECTS; ARTICLE; CHLOASMA; CLINICAL ARTICLE; CLINICAL RESEARCH; CONTROLLED STUDY; DRUG FORMULATION; EMULSION; HUMAN; LENTIGO; TREATMENT OUTCOME;

EID: 34547936708     PISSN: 13471813     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Japanese source
2. Japanese source
3. Japanese source
4. Japanese source
5. Japanese source
6. Japanese source
7. Japanese source
8. Japanese source
9. Japanese source
10. Griffiths CE, Finkel LJ, Ditre CM, Hamilton TA, Ellis CN, Voorhees JJ: Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled ria1. Br J Dermatol 1993; 129: 415-421
11. Japanese source
12. Verallo-Rowell VM, Verallo V, Graupe K, Lopez-Villafuerte L, Garcia-Lopez M: Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. Acta Derm Venereol Suppl (Stockh) 1989; 143: 8-61
13. Abiko Y and Iwamoto M: Plasminogen-plasmin system VII : Biochim Biophys Acta 1970; 214: 411-418
14. Japanese source
15. Japanese source
16. Chang WC, Shi GY, Chow YH et al: Human plasmin induces a receptor-mediated arachidonate release coupled with G proteins in endothelial cells. Am J Physiol 1993; 264: 271-281
17. Weide I, Tippler B, Syrovets T, Simmet T: Plasmin is a specific stimulus of the 5-lipoxygenase pathway of human peripheral monocytes. Thromb Haemost 1996; 76: 561-568
18. Japanese source
19. Nakahara M: Lysosomal enzyme activities in muscle with traumatically-induced edema. Pharmacology 1971; 6: 365-370
20. Isseroff RR and Rifkin DB: Plasminogen is present in the basal layer of the epidermis. J. Invest Dermatol 1983; 80: 297-299
21. Syrovets T, Jendrach M, Rohwedder A, Schüle A, Simmet T: Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKK-mediated NF-κB activation. Blood 2001; 97: 3941-3950
22. Burysek L, Syrovets T, Simmet T: The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and Janus kinase (JAK)/STAT signaling pathways. J Biol Chem 2002; 277: 33509-33517
23. Matsumura Y, Takada K, Murakami A, Takaoka M, Morimoto S: Plasmin stimulates expression of endothelin-1 mRNA and endothelin-1 release in vascular endothelial cells. Life Sci 1996; 58: 1067-1074
24. Naldini L, Tamagnone L, Vigna E, et al: Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 1992; 11: 4825-4833
25. Cho LH, Lee KM, Kim NS, Kanh W-H: The effect of whitening components on human melanocytes in vitro. 3rd Scientific Conference of the Asian Societies of Cosmetic Scientists 1997; 162-168
26. Japanese source