Spectroscopic imaging of the pilocarpine model of human epilepsy suggests that early NAA reduction predicts epilepsy

Magnetic Resonance in Medicine

Volumn 58, Issue 2, 2007, Pages 230-235

  Gomes, William A ^a   Lado, F A ^b   De Lanerolle, N C ^c   Takahashi, K ^b   Pan, C ^b   Hetherington, H P ^c  

^a MONTEFIORE MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; METABOLISM; NEURONS;

HIGH RESOLUTION; HIPPOCAMPAL NEURONS; MR SPECTROSCOPIC IMAGING; N-ACETYL ASPARTATE; NEURONAL LOSS; QUANTITATIVE ESTIMATES; SPECTROSCOPIC IMAGING; TEMPORAL LOBE EPILEPSY;

NEUROLOGY;

N ACETYLASPARTIC ACID; PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; BRAIN METABOLISM; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; HIGH RISK PATIENT; HIPPOCAMPUS; IMAGE RECONSTRUCTION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TEMPORAL LOBE EPILEPSY;

EID: 34547931096     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21310     Document Type: Article

References (40)

1. Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. N Engl J Med 1987;316:493-498.
2. Annegers JF, Hauser WA, Coan SP, Rocca WA. A population-based study of seizures after traumatic brain injuries. N Engl J Med 1998;338:20-24.
3. Spencer SS. When should temporal-lobe epilepsy be treated surgically? Lancet Neurol 2002;1:375-382.
4. French JA, Williamson PD, Thadani VM, Darcey TM, Mattson RH, Spencer SS, Spencer DD. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol 1993;34:774-780.
5. Lhatoo SD, Sander JW, Fish D. Temporal lobe epilepsy following febrile seizures: unusually prolonged latent periods. Eur Neurol 2001;46:165-166.
6. Hetherington HP, Kuzniecky RI, Pan JW, Vaughan JT, Twieg DB, Pohost GM. Application of high field spectroscopic imaging in the evaluation of temporal lobe epilepsy. Magn Reson Imaging 1995;13:1175-1180.
7. Hetherington HP, Pan JW, Spencer DD. 1H and 31P spectroscopy and bioenergetics in the lateralization of seizures in temporal lobe epilepsy. J Magn Reson Imaging 2002;16:477-483.
8. Connelly A, Jackson GD, Duncan JS, King MD, Gadian DG. Magnetic resonance spectroscopy in temporal lobe epilepsy. Neurology 1994;44:1411-1417.
9. Gadian DG, Connelly A, Duncan JS, Cross JH, Kirkham FJ, Johnson CL, Vargha-Khadem F, Nevile BG, Jackson GD. 1H magnetic resonance spectroscopy in the investigation of intractable epilepsy. Acta Neurol Scand Suppl 1994;152:116-121.
10. Hugg JW, Kuzniecky RI, Gilliam FG, Morawetz RB, Fraught RE, Hetherington HP. Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging. Ann Neurol 1996;40:236-239.
11. Martin RC, Sawrie S, Hugg J, Gilliam F, Faught E, Kuzniecky R. Cognitive correlates of 1H MRSI-detected hippocampal abnormalities in temporal lobe epilepsy. Neurology 1999;53:2052-2058.
12. Ng TC, Comair YG, Xue M, So N, Majors A, Kolem H, Luders H, Modic M. Temporal lobe epilepsy: presurgical localization with proton chemical shift imaging. Radiology 1994;193:465-472.
13. Kuzniecky R, Hetherington H, Pan J, Hugg J, Palmer C, Gilliam F, Faught E, Morawetz R. Proton spectroscopic imaging at 4.1 Tesla in patients with malformations of cortical development and epilepsy. Neurology 1997;48:1018-1024.
14. Li LM, Cendes F, Bastos AC, Andermann F, Dubeau F, Arnold DL. Neuronal metabolic dysfunction in patients with cortical developmental malformations: a proton magnetic resonance spectroscopic imaging study. Neurology 1993;50:755-759.
15. Series W, Li LM, Antel SB, Cendes F, Gotman J, Olivier A, Andermann F, Dubeau F, Arnold DL. Time course of postoperative recovery of N-acetyl-aspartate in temporal lobe epilepsy. Epilepsia 2001;42:190-197.
16. Vermathen P, Ende G, Laxer KD, Walker JA, Knowlton RC, Barbara NM, Matson GB, Weiner MW. Temporal lobectomy for epilepsy: recovery of the contralateral hippocampus measured by (1)H MRS. Neurology 2002;59:633-636.
17. Pan JW, Kim JH, Cohen-Gadol A, Pan C, Spencer DD, Hetherington HP. Regional energetic dysfunction in hippocampal epilepsy. Acta Neurol Scand 2005;111:218-224.
18. van der Grond J, Gerson JR, Laxer KD, Hugg JW, Matson GB, Weiner MW. Regional distribution of interictal 31P metabolic changes in patients with temporal lobe epilepsy. Epilepsia 1998;39:527-536.
19. Goldstein FB. The enzymatic synthesis of N-acetyl-L-aspartic acid by subcellular preparations of rat brain. J Biol Chem 1969;244:4257-4260.
20. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991;45:37-45.
21. Leite JP, Bortolotto ZA, Cavalheiro EA. Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy. Neurosci Biobehav Rev 1990;14:511-517.
22. Mello LE, Cavalheiro EA, Tan AM, Kupfer WR, Pretorius JK, Babb TL, Finch DM. Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 1993;34:985-995.
23. Dinocourt C, Petanjek Z, Freund TF, Ben-Ari Y, Esclapez M. Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures. J Comp Neurol 2003;459:407-425.
24. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32:281-294.
25. Miyasaka N, Takahashi K, Hetherington HP. Fully automated shim mapping method for spectroscopic imaging of the mouse brain at 9.4 T. Magn Reson Med 2006;55:198-202.
26. Bartha R, Michaeli S, Merkle H, Adriany G, Andersen P, Chen W, Ugurbil K, Garwood M. In vivo 1H2O T2+ measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrast. Magn Reson Med 2002;47:742-750.
27. Hetherington HP, Pan JW, Mason GF, Ponder SL, Twieg DB, Deutsch G, Mountz J, Pohost GM. 2D 1H spectroscopic imaging of the human brain at 4.1 T. Magn Reson Med 1994;32:530-534.
28. Twieg DB, Meyerhoff DJ, Hubesch B, Roth K, Sappey-Marinier D, Boska MD, Gober JR, Schaefer S, Weiner MW. Phosphorus-31 magnetic resonance spectroscopy in humans by spectroscopic imaging: localized spectroscopy and metabolite imaging. Magn Reson Med 1989;12:291-305.
29. West MJ, Slomianka L, Gundersen HJ. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991;231:482-497.
30. Pan JW, de Graaf RA, Petersen KF, Shulman GI, Hetherington HP, Rothman DL. [2,4-13 C2]-beta-hydroxybutyrate metabolism in human brain. J Cereb Blood Flow Metab 2002;22:890-898.
31. Najm IM, Wang Y, Hong SC, Luders HO, Ng TC, Comair YG. Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain. Epilepsia 1997;38:87-94.
32. Najm IM, Wang Y, Shedid D, Luders HO, Ng TC, Comair YG. MRS metabolic markers of seizures and seizure-induced neuronal damage. Epilepsia 1998;39:244-250.
33. Ebisu T, Rooney WD, Graham SH, Mancuso A, Weiner MW, Maudsley AA. MR spectroscopic imaging and diffusion-weighted MRI for early detection of kainate-induced status epilepticus in the rat. Magn Reson Med 1996;36:821-828.
34. Ebisu T, Rooney WD, Graham SH, Weiner MW, Maudsley AA. N-acetylaspartate as an in vivo marker of neuronal viability in kainate-induced status epilepticus: 1H magnetic resonance spectroscopic imaging. J Cereb Blood Flow Metab 1994;14:373-382.
35. Vielhaber S, Kudin AP, Kudina TA, Stiller D, Scheich H, Schoenfeld A, Feistner H, Heinze HJ, Elger CE, Kunz WS. Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats. Eur J Neurosci 2003;18:2292-2300.
36. Choi IY, Gruetter R. Dynamic or inert metabolism? Turnover of N-acetyl aspartate and glutathione from D-[1-13C]glucose in the rat brain in vivo. J Neurochem 2004;91:778-787.
37. Heales SJ, Davies SE, Bates TE, Clark JB. Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochem Res 1995;20:31-38.
38. Cendes F, Andermann F, Dubeau F, Matthews PM, Arnold DL. Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectroscopic imaging. Neurology 1997;49:1525-1533.
39. Cohen-Gadol AA, Pan JW, Kim JH, Spencer DD, Hetherington HH. Mesial temporal lobe epilepsy: a proton magnetic resonance spectroscopy study and a histopathological analysis. J Neurosurg 2004;101:613-620.
40. Herman ST. Epilepsy after brain insult: targeting epileptogenesis. Neurology 2002;59(Suppl 5):S21-S26.