Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle

Journal of Biological Chemistry

Volumn 282, Issue 31, 2007, Pages 22848-22855

  Liebert, Kirsten ^a   Horton, John R ^b   Chahar, Sanjay ^a   Orwick, Marcella ^a   Cheng, Xiaodong ^b   Jeltsch, Albert ^a  

^a JACOBS UNIVERSITY BREMEN   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CROSSLINKING; CRYSTAL STRUCTURE; DNA; ESCHERICHIA COLI; GENE EXPRESSION;

BINDING POCKETS; COMPETENT CONFORMATION; TERNARY COMPLEXES;

ENZYME KINETICS;

DNA; DNA ADENINE METHYLTRANSFERASE; HEXAPEPTIDE; HOMOCYSTEINE; LYSINE; S ADENOSYLHOMOCYSTEINE; TRYPTOPHAN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CROSS LINKING; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; FLUORESCENCE; NONHUMAN; PRIORITY JOURNAL;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA; DNA METHYLATION; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; S-ADENOSYLHOMOCYSTEINE; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); TIME FACTORS; TRYPTOPHAN;

ESCHERICHIA COLI;

EID: 34547929793     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700926200     Document Type: Article

References (34)

1. Lacks, S., and Greenberg, B. (1977) J. Mol. Biol. 114, 153-168
2. Hattman, S., Brooks, J. E., and Masurekar, M. (1978) J. Mol. Biol. 126, 367-380
3. Lobner-Olesen, A., Skovgaard, O., and Marinus, M. G. (2005) Curr. Opin. Microbiol. 8, 154-160
4. Horton, J. R., Liebert, K., Bekes, M., Jeltsch, A., and Cheng, X. (2006) J. Mol. Biol. 358, 559-570
5. Cheng, X. (1995) Curr. Opin. Struct. Biol. 5, 4-10
6. Cheng, X. (1995) Annu. Rev. Biophys. Biomol. Struct. 24, 293-318
7. Cheng, X., and Roberts, R. J. (2001) Nucleic Acids Res. 29, 3784-3795
8. Yang, Z., Horton, J. R., Zhou, L., Zhang, X. J., Dong, A., Zhang, X., Schlagman, S. L., Kossykh, V., Hattman, S., and Cheng, X. (2003) Nat. Struct. Biol. 10, 849-855
9. Horton, J. R., Liebert, K., Hattman, S., Jeltsch, A., and Cheng, X. (2005) Cell 121, 349-361
10. Bergerat, A., and Guschlbauer, W. (1990) Nucleic Acids Res. 18, 4369-4375
11. Bergerat, A., Guschlbauer, W., and Fazakerley, G. V. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 6394-6397
12. Liebert, K., Hermann, A., Schlickenrieder, M., and Jeltsch, A. (2004) J. Mol. Biol. 341, 443-454
13. Schubert, H. L., Blumenthal, R. M., and Cheng, X. (2003) Trends Biochem. Sci. 28, 329-335
14. Thomas, C. B., Scavetta, R. D., Gumport, R. I., and Churchill, M. E. (2003) J. Biol. Chem. 278, 26094-26101
15. Cheng, X., Kumar, S., Posfai, J., Pflugrath, J. W., and Roberts, R. J. (1993) Cell 74, 299-307
16. O'Gara, M., Zhang, X., Roberts, R. J., and Cheng, X. (1999) J. Mol. Biol. 287, 201-209
17. Studier, F. W. (2005) Protein Expression Purif. 41, 207-234
18. Jeltsch, A., and Lanio, T. (2002) Methods Mol. Biol. 182, 85-94
19. Tong, L., and Rossmann, M. G. (1997) Methods Enzymol. 276, 594-611
20. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
21. Roth, M., and Jeltsch, A. (2000) Biol. Chem. 381, 269-272
22. Gowher, H., Loutchanwoot, P., Vorobjeva, O., Handa, V., Jurkowska, R. Z., Jurkowski, T. P., and Jeltsch, A. (2006) J. Mol. Biol. 357, 928-941
23. Schluckebier, G., O'Gara, M., Saenger, W., and Cheng, X. (1995) J. Mol. Biol. 247, 16-20
24. Roth, M., Helm-Kruse, S., Friedrich, T., and Jeltsch, A. (1998) J. Biol. Chem. 273, 17333-17342
25. Sankpal, U. T., and Rao, D. N. (2002) Nucleic Acids Res. 30, 2628-2638
26. Wenzel, C., and Guschlbauer, W. (1993) Nucleic Acids Res. 21, 4604-4609
27. Schluckebier, G., Kozak, M., Bleimling, N., Weinhold, E., and Saenger, W. (1997) J. Mol. Biol. 265, 56-67
28. Urig, S., Gowher, H., Hermann, A., Beck, C., Fatemi, M., Humeny, A., and Jeltsch, A. (2002) J. Mol. Biol. 319, 1085-1096
29. Roth, M., and Jeltsch, A. (2001) Nucleic Acids Res. 29, 3137-3144
30. Allan, B. W., and Reich, N. O. (1996) Biochemistry 35, 14757-14762
31. Holz, B., Klimasauskas, S., Serva, S., and Weinhold, E. (1998) Nucleic Acids Res. 26, 1076-1083
32. Goedecke, K., Pignot, M., Goody, R. S., Scheidig, A. J., and Weinhold, E. (2001) Nat. Struct. Biol. 8, 121-125
33. Labahn, J., Granzin, J., Schluckebier, G., Robinson, D. P., Jack, W. E., Schildkraut, I., and Saenger, W. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 10957-10961
34. Malone, T., Blumenthal, R. M., and Cheng, X. (1995) J. Mol. Biol. 253, 618-632