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Volumn 16, Issue 5, 2007, Pages 416-421

Renin inhibitors: Novel agents for renoprotection or a better angiotensin receptor blocker for blood pressure lowering?

Author keywords

Angiotensin II; Hypertension; Plasma renin activity; Renin inhibition; Renoprotection

Indexed keywords

ALISKIREN; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; IRBESARTAN; PLACEBO; RENIN INHIBITOR; THIAZIDE DIURETIC AGENT; VALSARTAN;

EID: 34547921333     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328209fe00     Document Type: Review
Times cited : (11)

References (23)
  • 1
    • 0141789624 scopus 로고    scopus 로고
    • Progression of chronic kidney disease: The role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    • Jafar TH, Stark PC, Schmid CH, et al. Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis. Ann Intern Med 2003; 139:244-252.
    • (2003) Ann Intern Med , vol.139 , pp. 244-252
    • Jafar, T.H.1    Stark, P.C.2    Schmid, C.H.3
  • 2
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345:861-869.
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3
  • 3
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001; 345:851-860.
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 4
    • 0035922444 scopus 로고    scopus 로고
    • The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • Parving HH, Lehnert H, Brochner-Mortensen J, et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345:870-878.
    • (2001) N Engl J Med , vol.345 , pp. 870-878
    • Parving, H.H.1    Lehnert, H.2    Brochner-Mortensen, J.3
  • 5
    • 33644912981 scopus 로고    scopus 로고
    • Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: Clinical implications and limitations
    • Pohl MA, Blumenthal S, Cordonnier DJ, et al. Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations. J Am Soc Nephrol 2005; 16:3027-3037.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3027-3037
    • Pohl, M.A.1    Blumenthal, S.2    Cordonnier, D.J.3
  • 6
    • 0038155497 scopus 로고    scopus 로고
    • Effects of blood pressure level on progression of diabetic nephropathy: Results from the RENAAL study
    • Bakris GL, Weir MR, Shanifar S, et al. Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study. Arch Intern Med 2003; 163:1555-1565.
    • (2003) Arch Intern Med , vol.163 , pp. 1555-1565
    • Bakris, G.L.1    Weir, M.R.2    Shanifar, S.3
  • 7
    • 0035997523 scopus 로고    scopus 로고
    • Pathophysiologic and therapeutic importance of tissue ACE: A consensus report
    • Dzau VJ, Bernstein K, Celermajer D, et al. Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. Cardiovasc Drugs Ther 2002; 16:149-160.
    • (2002) Cardiovasc Drugs Ther , vol.16 , pp. 149-160
    • Dzau, V.J.1    Bernstein, K.2    Celermajer, D.3
  • 8
    • 33748070612 scopus 로고    scopus 로고
    • Clin J Am Soc Nephrol, A good review of the mechanisms behind renin inhibition with some experimental and clinical observations
    • Muller DM, Luft FC. Direct renin inhibition with aliskiren in hypertension and target organ damage. Clin J Am Soc Nephrol 2006; 1:221-228. A good review of the mechanisms behind renin inhibition with some experimental and clinical observations.
    • (2006) Direct renin inhibition with aliskiren in hypertension and target organ damage , vol.1 , pp. 221-228
    • Muller, D.M.1    Luft, F.C.2
  • 9
    • 0032512094 scopus 로고    scopus 로고
    • Pathophysiology of progressive nephropathies
    • Remuzzi G, Bertani T. Pathophysiology of progressive nephropathies. N Engl J Med 1998; 339:1448-1456.
    • (1998) N Engl J Med , vol.339 , pp. 1448-1456
    • Remuzzi, G.1    Bertani, T.2
  • 10
    • 33646523408 scopus 로고    scopus 로고
    • Renal risk and renoprotection among ethnic groups with type 2 diabetic nephropathy: A post hoc analysis of RENAAL
    • An important paper correlating change in albuminuria with risk for progression of kidney disease
    • de Zeeuw D, Ramjit D, Zhang Z, et al. Renal risk and renoprotection among ethnic groups with type 2 diabetic nephropathy: a post hoc analysis of RENAAL. Kidney Int 2006; 69:1675-1682. An important paper correlating change in albuminuria with risk for progression of kidney disease.
    • (2006) Kidney Int , vol.69 , pp. 1675-1682
    • de Zeeuw, D.1    Ramjit, D.2    Zhang, Z.3
  • 11
    • 0027499036 scopus 로고
    • Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors
    • Borghi C, Boschi S, Ambrosioni E, et al. Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors. J Clin Pharmacol 1993; 33:40-45.
    • (1993) J Clin Pharmacol , vol.33 , pp. 40-45
    • Borghi, C.1    Boschi, S.2    Ambrosioni, E.3
  • 12
    • 0033989542 scopus 로고    scopus 로고
    • Clinical implications of increased plasma angiotensin II despite ACE inhibitor therapy in patients with congestive heart failure
    • Roig E, Perez-Villa F, Morales M, et al. Clinical implications of increased plasma angiotensin II despite ACE inhibitor therapy in patients with congestive heart failure. Eur Heart J 2000; 21:53-57.
    • (2000) Eur Heart J , vol.21 , pp. 53-57
    • Roig, E.1    Perez-Villa, F.2    Morales, M.3
  • 13
    • 33749985149 scopus 로고    scopus 로고
    • Staessen JA, Li Y, Richart T. Oral renin inhibitors. Lancet 2006; 368:1449-1456. A good review of clinical results with renin inhibitors.
    • Staessen JA, Li Y, Richart T. Oral renin inhibitors. Lancet 2006; 368:1449-1456. A good review of clinical results with renin inhibitors.
  • 14
    • 14844363404 scopus 로고    scopus 로고
    • Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
    • Gradman AH, Schmieder RE, Lins RL, et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005; 111:1012-1018.
    • (2005) Circulation , vol.111 , pp. 1012-1018
    • Gradman, A.H.1    Schmieder, R.E.2    Lins, R.L.3
  • 15
    • 34547870403 scopus 로고    scopus 로고
    • The renin inhibitor aliskiren ameliorates hypertensive diabetic nephropathy in transgenic (mRen-2)27 (Ren-2) Rats
    • Feldman DL, Jin L, Miserendino-Moltini R, et al. The renin inhibitor aliskiren ameliorates hypertensive diabetic nephropathy in transgenic (mRen-2)27 (Ren-2) Rats. J Am Soc Nephrol 2005; 16:213A.
    • (2005) J Am Soc Nephrol , vol.16
    • Feldman, D.L.1    Jin, L.2    Miserendino-Moltini, R.3
  • 16
    • 34547882245 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor induces persistent renoprotection comparable to ace inhibition in double transgenic rats (DTGR) [abstract]
    • Feldman DL, Jin L, Miserendino-Moltini R, et al. Aliskiren, a human renin inhibitor induces persistent renoprotection comparable to ace inhibition in double transgenic rats (DTGR) [abstract]. Am J Hypertens 2005; 18(5 Part 2):230A.
    • (2005) Am J Hypertens , vol.18 , Issue.5 PART 2
    • Feldman, D.L.1    Jin, L.2    Miserendino-Moltini, R.3
  • 17
    • 25444454353 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
    • Pilz B, Shagdarsuren E, Wellner M, et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension 2005; 46:569-576.
    • (2005) Hypertension , vol.46 , pp. 569-576
    • Pilz, B.1    Shagdarsuren, E.2    Wellner, M.3
  • 18
    • 20544440652 scopus 로고    scopus 로고
    • Renin inhibition: What are the therapeutic opportunities?
    • Fisher ND, Hollenberg NK. Renin inhibition: what are the therapeutic opportunities? J Am Soc Nephrol 2005; 16:592-599.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 592-599
    • Fisher, N.D.1    Hollenberg, N.K.2
  • 19
    • 0031688757 scopus 로고    scopus 로고
    • Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
    • Hollenberg NK, Fisher ND, Price DA. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension 1998; 32:387-392.
    • (1998) Hypertension , vol.32 , pp. 387-392
    • Hollenberg, N.K.1    Fisher, N.D.2    Price, D.A.3
  • 20
    • 85190640452 scopus 로고    scopus 로고
    • 1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004; 15:3126-3133.
    • 1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004; 15:3126-3133.
  • 22
    • 36348966827 scopus 로고    scopus 로고
    • The direct renin inhibitor aliskiren in combination with valsartan provides additional blood pressure-lowering effects compared with either agent alone in patients with hypertension [abstract]
    • Oparil S, Yarows SA, Patel S, et al. The direct renin inhibitor aliskiren in combination with valsartan provides additional blood pressure-lowering effects compared with either agent alone in patients with hypertension [abstract]. J Clin Hypertens 2007; 9 (Suppl A):A174.
    • (2007) J Clin Hypertens , vol.9 , Issue.SUPPL. A
    • Oparil, S.1    Yarows, S.A.2    Patel, S.3
  • 23
    • 27444447364 scopus 로고    scopus 로고
    • Renin, prorenin and the putative (pro)renin receptor
    • A complete basic science summary of renin and prorenin receptors and their potential impact on disease
    • Danser AH, Deinum J. Renin, prorenin and the putative (pro)renin receptor. Hypertension 2005; 46:1069-1076. A complete basic science summary of renin and prorenin receptors and their potential impact on disease.
    • (2005) Hypertension , vol.46 , pp. 1069-1076
    • Danser, A.H.1    Deinum, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.