Delayed-type hypersensitivity to low molecular weight heparins and heparinoids: Cross-reactivity does not depend on molecular weight

British Journal of Dermatology

Volumn 157, Issue 3, 2007, Pages 514-517

  Grims, R H ^a   Weger, W ^a   Reiter, H ^a   Arbab, E ^a   Kranke B ^a   Aberer, W ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Bemiparin; Cross reactivity; Delayed type hypersensitivity; Low molecular weight heparins; Molecular weight

Indexed keywords

BEMIPARIN; CERTOPARIN; DALTEPARIN; DANAPAROID; ENOXAPARIN; FONDAPARINUX; IVOR; NADROPARIN; PENTOSAN POLYSULFATE; POLYANION; REVIPARIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANAMNESIS; ARTICLE; CLINICAL ARTICLE; CROSS REACTION; DELAYED HYPERSENSITIVITY; DRUG TOLERABILITY; ECZEMA; ERYTHEMA; FEMALE; HUMAN; MALE; MOLECULAR WEIGHT; PRIORITY JOURNAL; SWELLING;

AGED; ANTICOAGULANTS; CROSS REACTIONS; DRUG ERUPTIONS; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HEPARINOIDS; HUMANS; HYPERSENSITIVITY, DELAYED; MALE; MIDDLE AGED; MOLECULAR WEIGHT; SKIN TESTS;

EID: 34547920706     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2007.08007.x     Document Type: Article

References (14)

1. Mendez J, Sanchis ME, de la Fuente R et al. Delayed-type hypersensitivity to subcutaneous enoxaparin. Allergy 1998 53 : 999 1003.
2. Ludwig RJ, Schindewolf M, Alban S et al. Molecular weight determines the frequency of delayed type hypersensitivity reactions to heparin and synthetic oligosaccharides. Thromb Haemost 2005 94 : 1265 9.
3. Planes A. Review of bemiparin sodium - a new second-generation low molecular weight heparin and its applications in venous thromboembolism. Expert Opin Pharmacother 2003 4 : 1551 61.
4. Bircher AJ, Harr T, Hohenstein L, Tsakiris DA. Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options. Allergy 2006 61 : 1432 40.
5. Boehncke WH, Weber L, Gall H. Tolerance to intravenous administration of heparin and heparinoid in a patient with delayed-type hypersensitivity to heparins and heparinoids. Contact Dermatitis 1996 35 : 73 5.
6. Koch P, Bahmer FA, Schafer H. Tolerance of intravenous low-molecular-weight heparin after eczematous reaction to subcutaneous heparin. Contact Dermatitis 1991 25 : 205 6.
7. Koch P, Munssinger T, Rupp-John C, Uhl K. Delayed-type hypersensitivity skin reactions caused by subcutaneous unfractionated and low-molecular-weight heparins: tolerance of a new recombinant hirudin. J Am Acad Dermatol 2000 42 : 612 19.
8. Szolar-Platzer C, Aberer W, Kränke B. Delayed-type skin reaction to the heparin-alternative danaparoid. J Am Acad Dermatol 2000 43 : 920 2.
9. Greinacher A, Lubenow N, Eichler P. Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia. Circulation 2003 108 : 2062 5.
10. Klein GF, Kofler H, Wolf H, Fritsch PO. Eczema-like, erythematous, infiltrated plaques: a common side effect of subcutaneous heparin therapy. J Am Acad Dermatol 1989 21 : 703 7.
11. Jappe U, Juschka U, Kuner N et al. Fondaparinux: a suitable alternative in cases of delayed-type allergy to heparins and semisynthetic heparinoids? A study of 7 cases. Contact Dermatitis 2004 51 : 67 72.
12. Hohenstein E, Tsakiris D, Bircher AJ. Delayed-type hypersensitivity to the ultra-low-molecular-weight heparin fondaparinux. Contact Dermatitis 2004 51 : 149 51.
13. Maetzke J, Hinrichs R, Schneider LA, Scharffetter-Kochanek K. Unexpected delayed-type hypersensitivity skin reactions to the ultra-low-molecular-weight heparin fondaparinux. Allergy 2005 60 : 413 15.
14. Grassegger A, Fritsch P, Reider N. Delayed-type hypersensitivity and cross-reactivity to heparins and danaparoid: a prospective study. Dermatol Surg 2001 27 : 47 52.