Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants

Hormone Research

Volumn 68, Issue 3, 2007, Pages 124-131

  Elmlinger, Martin W ^a   Hochhaus, Frederike ^b   Loui, Andrea ^c,d   Frommer, Klaus W ^a   Obladen, Michael ^c   Ranke, Michael B ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Breast feeding; Insulin like growth factor binding proteins; Insulin like growth factors; Mother's milk; Preterm infant; Proteolysis

Indexed keywords

BINDING PROTEIN; IODINE 125; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ARTICLE; CHILD GROWTH; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIGESTION; ELECTROPHORESIS; HUMAN; IMMUNOBLOTTING; INCUBATION TIME; INFANT; MILK; PREMATURITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PUERPERIUM; RADIOIMMUNOASSAY; STOMACH JUICE; TERM BIRTH;

ADULT; BREAST FEEDING; ENDOPEPTIDASES; FEMALE; GASTRIC JUICE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MILK, HUMAN; PILOT PROJECTS; POSTPARTUM PERIOD; PREGNANCY; RADIOIMMUNOASSAY; SOMATOMEDINS;

EID: 34547908174     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000100488     Document Type: Article

References (55)

1. Obladen M, Segerer H: Surfactant substitution in very small premature infants. Monatsschr Kinderheilkd 1991;139:2-15.
2. Sinn JK, Ward MC, Henderson-Smart DJ: Developmental outcome of preterm infants after surfactant therapy: systematic review of randomized controlled trials. J Paediatr Child Health 2002;38:597-600.
3. Wolf MJ, Koldewijn K, Beelen A, Smit B, Hedlund R, de Groot IJ: Neurobehavioral and developmental profile of very low birthweight preterm infants in early infancy. Acta Paediatr 2002;91:930-938.
4. Volpe JJ: Neurologic outcome of prematurity. Arch Neurol 1998;55:297-300.
5. Clark RH, Thomas P, Peabody J: Extrauterine growth restriction remains a serious problem in prematurely born neonates. Pediatrics 2003;111:986-990.
6. Cooke RW, Foulder-Hughes L: Growth impairment in the very preterm and cognitive and motor performance at 7 years. Arch Dis Child 2003;88:482-487.
7. Vanhaesebrouck P, Allegaert K, Bottu J, Debauche C, Devlieger H, Docx M, Francois A, Haumont D, Lombet J, Rigo J, Smets K, Vanherreweghe I, Van Overmeire B, Van Reempts P: Extremely preterm infants in Belgium study group. The EPIBEL study: outcomes to discharge from hospital for extremely preterm infants in Belgium. Pediatrics 2004;114:663-675.
8. Denne SC: Protein and energy requirements in preterm infants. Semin Neonatol 2001;6:377-382.
9. Rings EH, Minich DM, Vonk RJ, Stellaard F, Fetter WP, Verkade HJ: Functional development of fat absorption in term and preterm neonates strongly correlates with ability to absorb long-chain fatty acids from intestinal lumen. Pediatr Res 2002;51:57-63.
10. Koletzko B: Lipid supply and metabolism in infancy. Curr Opin Clin Nutr Metab Care 1998;1:171-177.
11. van Wezel-Meijler G, van der Knaap MS, Huisman J, Jonkman EJ, Valk J, Lafeber HN: Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation. Acta Paediatr 2002;91:942-950.
12. Lucas A, Morley R, Cole TJ, Gore MS, Lucas PJ, Crowle P, Boon AJ, Powell R: Early diet in preterm babies and developmental status at 18 months. Lancet 1990;335:1477-1481.
13. Lucas A, Morley R, Cole TJ, Lister G, Leeson-Payne C: Breast milk and subsequent intelligence quotient in children born preterm. Lancet 1992;339:261-264.
14. Baxter RC, Zaltsman Z, Turtle JR: Immunoreactive somatomedin-C/insulin- like growth factor I and its binding protein in human milk. J Clin Endocrinol Metab 1984;58:955-959.
15. Grosvenor CE, Picciano MF, Baumrucker CR: Hormones and growth factors in milk. Endocr Rev 1993;14:710-728.
16. Bernt KM, Walker WA: Human milk as a carrier of biochemical messages. Acta Paediatr Suppl 1999:88:27-41.
17. Burrin DG: Is milk-borne insulin-like growth factor-I essential for neonatal development? J Nutr 1997;127:975S-979S.
18. Ma L, Xu RJ: Oral insulin-like growth factor-I stimulates intestinal enzyme maturation in newborn rats. Life Sci 1997;61:51-58.
19. Wagner CL, Forsythe DW: Effect of human milk and recombinant EGF, TGF-α, and IGF-1 on small intestinal cell proliferation. Adv Exp Med Bio 2000;478:373-374.
20. Kimble RM, Breier BH, Gluckman PD, Harding JE: Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep. J Endocrinol 1999;162:227-235.
21. Zumkeller W: Relationship between insulin-like growth factor-I and -II and IGF-binding proteins in milk and the gastrointestinal tract: growth and development of the gut. J Pediatr Gastroenterol Nutr 1992;15:357-369.
22. Cohick WS, Clemmons DR: The insulin-like growth factors. Annu Rev Physiol 1993;55:131-153.
23. Collett-Solberg PF, Cohen P: Genetics, chemistry, and function of the IGF/IGFBP-system. Endocrine 2000;12:121-136.
24. Elmlinger MW, Grund R, Buck M, Wollmann HA, Feist N, Weber MM, Speer CP, Ranke MB: Limited proteolysis of the IGF binding protein-2 (IGFBP-2) by a specific serine protease activity in early breast milk. Pediatr Res 1999;46:76-81.
25. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC: Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.
26. Dvorak B, Fituch CC, Williams CS, Hurst NM, Schanler RJ: Increased epidermal growth factor levels in human milk of mothers with extremely premature infants. Pediatr Res 2003;54:15-19.
27. Donovan SM, McNeil LK, Jiminez-Flores R, Odle J: Insulin-like growth factors and insulin-like growth factor binding proteins in porcine serum and milk throughout lactation. Pediatr Res 1994;36:159-168.
28. Skalkidou A, Petridou E, Papathoma E, Salvanos H, Trichopoulos D: Growth velocity during the first postnatal week of life is linked to a spurt of IGF-I effect. Paediatr Perinat Epidemiol 2003;17:281-286.
29. Kajantie E: Insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1 and postnatal growth in very-low-birth-weight infants. Horm Res 2003;60(suppl 3):124-130.
30. Lo HC, Tsao LY, Hsu WY, Chi CY, Tsai FA: Changes in serum insulin-like growth factors, not leptin, are associated with postnatal weight gain in preterm neonates. J Parenter Enteral Nutr 2005;29:87-92.
31. Smith WJ, Nam TJ, Underwood LE, Busby WH, Celnicker A, Clemmons DR: Use of insulin-like growth factor-binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children. J Clin Endocrinol Metab 1993;77:1294-1299.
32. Skalkidou A, Petridou E, Papathoma E, Salvanos H, Kedikoglou S, Chrousos G, Trichopoulos D: Determinants and consequences of major insulin-like growth factor components among full-term healthy neonates. Cancer Epidemiol Biomarkers Prev 2003;12:860-865.
33. Weber A, Loui A, Jochum F, Buehrer C, Obladen M: Very low birthweight infant mothers breast milk: fat and protein content are highly variable. Acta Paediatr 2001;90:772-775.
34. Schlimme E, Martin D, Meisel H: Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. Br J Nutr 2000;84(suppl 1):S59-S68.
35. Hamosh M: Bioactive factors in human milk. Pediatr Clin North Am 2001;48:49-86.
36. Bastian SE, Walton PE, Ballard FJ, Belford DA: Transport of IGF-I across epithelial cell monolayers. J Endocrinol 1999;162:361-369.
37. Steeb CB, Shoubridge CA, Tivey DR, Read LC: Systemic infusion of IGF-I or LR(3)IGFI stimulates visceral organ growth and proliferation of gut tissues in suckling rats. Am J Physiol 1997;272:G522-G533.
38. Zumkeller W: The effect of insulin-like growth factors on brain myelination and their potential therapeutic application in myelination disorders. Eur J Paediatr Neurol 1997;1:91-101.
39. Anderle P, Langguth P, Rubas W, Merkle HP: In vitro assessment of intestinal IGF-I stability. J Pharm Sci 2002;91:290-300.
40. Playford RJ, Marchbank T, Calnan DP, Calam J, Royston P, Batten JJ, Hansen HF: Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice. Gastroenterology 1995;108:92-101.
41. Nagashima K, Itoh K, Kuroume T: Levels of insulin-like growth factor I in full- and preterm human milk in comparison to levels in cow's milk and in milk formulas. Biol Neonate 1990;58:343-346.
42. Donovan SM, Odle J: Growth factors in milk as mediators of infant development. Annu Rev Nutr 1994;14:147-167.
43. Schams D: Growth factors in milk. Endocr Regul 1994;28:3-8.
44. Prosser CG: Insulin-like growth factors in milk and mammary gland. J Mammary Gland Biol Neoplasia 1996;1:297-306.
45. Ho PJ, Baxter RC: Characterization of truncated insulin-like growth factor-binding protein-2 in human milk. Endocrinology 1997;138:3811-3818.
46. Firth SM, Baxter RC: Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 2002;23:824-854.
47. Shalamanova L, Kubler B, Scharf JG, Braulke T: MDCK cells secrete neutral proteases cleaving insulin-like growth factor-binding protein-2 to -6. Am J Physiol 2001;281:E1221-E1229.
48. Schutt BS, Langkamp M, Rauschnabel U, Ranke MB, Elmlinger MW: Integrin-mediated action of insulin-like growth factor binding protein-2 in tumor cells. J Mol Endocrinol 2004;32:859-868.
49. Russo VC, Schutt BS, Andaloro E, Ymer SI, Hoeflich A, Ranke MB, Bach LA, Werther GA: Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion. Endocrinology 2005;146:4445-4455.
50. Chard T: Insulin-like growth factors and their binding proteins in normal and abnormal fetal growth. Growth Regul 1994;4:91-100.
51. Lauterio TJ: The effects of IGF-I and IGF-II on cell growth and differentiation in the central nervous system. Adv Exp Med Biol 1992;321:31-36.
52. Blum JW, Baumrucker CR: Colostral and milk insulin-like growth factors and related substances: mammary gland and neonatal (intestinal and systemic) targets. Domest Anim Endocrinol 2002;23:101-110.
53. Dvorák B, Stephana AL, Holubec H, Williams CS, Philipps AF, Koldovskoý O: Insulin-like growth factor I (IGF-I) mRNA in the small intestine of suckling and adult rats. FEBS Lett 1996;388:155-160.
54. Georgiev IP, Georgieva TM, Pfaffl M, Hammon HM, Blum JW: Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves. J Endocrinol 2003;176:121-132.
55. Sigalet DL, Martin GR: Hormonal therapy for short bowel syndrome. J Pediatr Surg 2000;35:360-363.