Aspirin and bleeding in dentistry: an update and recommendations

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 104, Issue 3, 2007, Pages 316-323

  Brennan, Michael T ^a   Wynn, Richard L ^b   Miller, Craig S ^c  

^a CAROLINAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^c UNIVERSITY OF KENTUCKY COLLEGE OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; BLEEDING; CARDIOVASCULAR DISEASE; CHEMICALLY INDUCED DISORDER; DENTAL CARE; DRUG EFFECT; HUMAN; METHODOLOGY; PERIODONTICS; POSTOPERATIVE HEMORRHAGE; THROMBOCYTE; THROMBOSIS; WITHDRAWAL SYNDROME;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BLOOD PLATELETS; CARDIOVASCULAR DISEASES; DENTAL CARE; HEMORRHAGE; HUMANS; PERIODONTAL INDEX; POSTOPERATIVE HEMORRHAGE; SUBSTANCE WITHDRAWAL SYNDROME; THROMBOSIS;

EID: 34547902116     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2007.03.003     Document Type: Article

References (66)

1. Ajani U.A., Ford E.S., Greenland K.J., Giles W.H., and Mokdad A.H. Aspirin use among U.S. adults: Behavioral Risk Factor Surveillance System. Am J Prev Med 30 (2006) 74-77
2. Patrono C., and Rocca B. Drug insight: aspirin resistance-fact or fashion?. Nat Clin Pract Cardiovasc Med 4 (2007) 42-50
3. Mehta A. Aspirin. C&E News 20 (2005) 46-47
4. Hermann M., Krum H., and Ruschitzka F. To the heart of the matter: coxibs, smoking, and cardiovascular risk. Circulation 112 (2005) 941-945
5. Reiter R., Resch U., and Sinzinger H. Do human platelets express COX-2?. Prostaglandins Leukot Essent Fatty Acids 64 (2001) 299-305
6. McAdam B.F., Byrne D., Morrow J.D., and Oates J.A. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. Circulation 112 (2005) 1024-1029
7. Rocca B., Secchiero P., Ciabattoni G., Ranelletti F.O., Catani L., Guidotti L., et al. Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci U S A 99 (2002) 7634-7639
8. Weber A.A., Przytulski B., Schumacher M., Zimmermann N., Gams E., Hohlfeld T., et al. Flow cytometry analysis of platelet cyclooxygenase-2 expression: induction of platelet cyclooxygenase-2 in patients undergoing coronary artery bypass grafting. Br J Haematol 117 (2002) 424-426
9. Patrignani P., Filabozzi P., and Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 69 (1982) 1366-1372
10. FitzGerald G.A., Oates J.A., Hawiger J., Maas R.L., Roberts II L.J., Lawson J.A., et al. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest 71 (1983) 676-688
11. Gan R., Teleg R.A., Florento L., and Bitanga E.S. Effect of increasing doses of aspirin on platelet aggregation among stroke patients. Cerebrovasc Dis 14 (2002) 252-255
12. Antithrombotic Trialist's Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 24 (2002) 71-86
13. Patrono C., Ciabattoni G., Patrignani P., Pugliese F., Filabozzi P., Catella F., et al. Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation 72 (1985) 1177-1184
14. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308 (1994) 81-106
15. Garcia Rodriguez L.A., Hernandez-Diaz S., and de Abajo F.J. Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies. Br J Clin Pharmacol 52 (2001) 563-571
16. Sanmuganathan P.S., Ghahramani P., Jackson P.R., Wallis E.J., and Ramsay L.E. Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials. Heart 85 (2001) 265-271
17. Patrono C., Coller B., FitzGerald G.A., Hirsh J., and Roth G. Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (2004) 234S-264S
18. Macchi L., Sorel N., and Christiaens L. Aspirin resistance: definitions, mechanisms, prevalence, and clinical significance. Curr Pharm Des 12 (2006) 251-258
19. Sanderson S., Emery J., Baglin T., and Kinmonth A.L. Narrative review: aspirin resistance and its clinical implications. Ann Intern Med 142 (2005) 370-380
20. Mason P.J., Jacobs A.K., and Freedman J.E. Aspirin resistance and atherothrombotic disease. J Am Coll Cardiol 46 (2005) 986-993
21. Hanjis C., Frishman W.H., and Lerner R.G. Aspirin resistance: mechanisms and clinical implications. Cardiol Rev 14 (2006) 18-25
22. Szczeklik A., Musial J., Undas A., Sanak M., and Nizankowski R. Aspirin resistance. Pharmacol Rep 57 Suppl (2005) 33-41
23. Halushka M.K., Walker L.P., and Halushka P.V. Genetic variation in cyclooxygenase 1: effects on response to aspirin. Clin Pharmacol Ther 73 (2003) 122-130
24. Maree A.O., Curtin R.J., Chubb A., Dolan C., Cox D., O'Brien J., et al. Cyclooxygenase-1 haplotype modulates platelet response to aspirin. J Thromb Haemost 3 (2005) 2340-2345
25. Helgason C.M., Bolin K.M., Hoff J.A., Winkler S.R., Mangat A., Tortorice K.L., et al. Development of aspirin resistance in persons with previous ischemic stroke. Stroke 25 (1994) 2331-2336
26. Royzman D., Recio L., Badovinac R.L., Fiorellini J., Goodson M., Howell H., et al. The effect of aspirin intake on bleeding on probing in patients with gingivitis. J Periodontol 75 (2004) 679-684
27. Schrodi J., Recio L., Fiorellini J., Howell H., Goodson M., and Karimbux N. The effect of aspirin on the periodontal parameter bleeding on probing. J Periodontol 73 (2002) 871-876
28. Lemkin S.R., Billesdon J.E., Davee J.S., Leake D.L., and Kattlove H.E. Aspirin-induced oral bleeding: correction with platelet transfusion. A reminder. Oral Surg Oral Med Oral Pathol 37 (1974) 498-501
29. McGaul T. Postoperative bleeding caused by aspirin. J Dent 6 (1978) 207-209
30. Thomason J.M., Seymour R.A., Murphy P., Brigham K.M., and Jones P. Aspirin-induced post-gingivectomy haemorrhage: a timely reminder. J Clin Periodontol 24 (1997) 136-138
31. Ardekian L., Gaspar R., Peled M., Brener B., and Laufer D. Does low-dose aspirin therapy complicate oral surgical procedures?. J Am Dent Assoc 131 (2000) 331-335
32. Madan G.A., Madan S.G., Madan G., and Madan A.D. Minor oral surgery without stopping daily low-dose aspirin therapy: a study of 51 patients. J Oral Maxillofac Surg 63 (2005) 1262-1265
33. Valerin M.A., Brennan M.T., Noll J.L., Napeñas J.J., Kent M.L., Fox P.C., et al. Relationship between aspirin use and postoperative bleeding from dental extractions in a healthy population. [abstract]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 (2006) 326
34. Steinhubl S.R. Optimizing antiplatelet therapy for the ACS patient: reacting to clinical trial data from the ISAR-REACT-2 studies. Rev Cardiovasc Med 7 Suppl 4 (2006) S12-S19
35. Bhatt D.L. Clopidogrel bisulfate in ST-segment elevation myocardial infarction: a viewpoint by Deepak L. Bhatt. Am J Cardiovasc Drugs 6 (2006) 415-416
36. Chu M.W., Wilson S.R., Novick R.J., Stitt L.W., and Quantz M.A. Does clopidogrel increase blood loss following coronary artery bypass surgery?. Ann Thorac Surg 78 (2004) 1536-1541
37. Leong J.Y., Baker R.A., Shah P.J., Cherian V.K., and Knight J.L. Clopidogrel and bleeding after coronary artery bypass graft surgery. Ann Thorac Surg 80 (2005) 928-933
38. Grines C.L., Bonow R.O., Casey Jr. D.E., Gardner T.J., Lockhart P.B., Moliterno D.J., et al. Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents. A science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, with representation from the American College of Physicians. Circulation 115 (2007) 813-818
39. Collet J.P., Montalescot G., Blanchet B., Tanguy M.L., Golmard J.L., Choussat R., et al. Impact of prior use or recent withdrawal of oral antiplatelet agents on acute coronary syndromes. Circulation 110 (2004) 2361-2367
40. Ferrari E., Benhamou M., Cerboni P., and Marcel B. Coronary syndromes following aspirin withdrawal: a special risk for late stent thrombosis. J Am Coll Cardiol 45 (2005) 456-459
41. Aspirin: quitting cold turkey could be dangerous. Studies have linked aspirin withdrawal to heart attacks. Harv Health Lett 30 (2005) 6
42. Fischer L.M., Schlienger R.G., Matter C.M., Jick H., and Meier C.R. Discontinuation of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction. Arch Intern Med 164 (2004) 2472-60
43. Scully C., and Wolff A. Oral surgery in patients on anticoagulant therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94 (2002) 57-64
44. Little J.W., Miller C.S., Henry R.G., and McIntosh B.A. Antithrombotic agents: implications in dentistry. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93 (2002) 544-551
45. Amrein P.C., Ellman L., and Harris W.H. Aspirin-induced prolongation of bleeding time and perioperative blood loss. JAMA 245 (1981) 1825-1828
46. Brennan M.T., Shariff G., Kent M.L., Fox P.C., and Lockhart P.B. Relationship between bleeding time test and postextraction bleeding in a healthy control population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94 (2002) 439-443
47. Lind S.E. Prolonged bleeding time. Am J Med 77 (1984) 305-312
48. Barber A., Green D., Galluzzo T., and Ts'ao C.H. The bleeding time as a preoperative screening test. Am J Med 78 (1985) 761-764
49. De Caterina R., Lanza M., Manca G., Strata G.B., Maffei S., and Salvatore L. Bleeding time and bleeding: an analysis of the relationship of the bleeding time test with parameters of surgical bleeding. Blood 84 (1994) 3363-3370
50. Pawlak D.F., Itkin A.B., Lapeyrolerie F.M., and Zweig B. Clinical effects of aspirin and acetaminophen on hemostasis after exodontics. J Oral Surg 36 (1978) 944-947
51. Mielke Jr. C.H. Aspirin prolongation of the template bleeding time: influence of venostasis and direction of incision. Blood 60 (1982) 1139-1142
52. Peterson P., Hayes T.E., Arkin C.F., Bovill E.G., Fairweather R.B., Rock Jr. W.A., et al. The preoperative bleeding time test lacks clinical benefit: College of American Pathologists' and American Society of Clinical Pathologists' position article. Arch Surg 133 (1998) 134-139
53. Harrison P. Platelet function analysis. Blood Rev 19 (2005) 111-123
54. Ryan W.L., Hakenkamp K., and Sullivan E. A new platelet function test. Thromb Res 58 (1990) 163-173
55. Malhotra S., Sharma Y.P., Grover A., Majumdar S., Hanif S.M., Bhargava V.K., et al. Effect of different aspirin doses on platelet aggregation in patients with stable coronary artery disease. Intern Med J 33 (2003) 350-354
56. Macie C., Forbes L., Foster G.A., and Douketis J.D. Dosing practices and risk factors for bleeding in patients receiving enoxaparin for the treatment of an acute coronary syndrome. Chest 125 (2004) 1616-1621
57. Moscucci M., Fox K.A., Cannon C.P., Klein W., Lopez-Sendon J., Montalescot G., et al. Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE). Eur Heart J 24 (2003) 1815-1823
58. Conti C.R. Aspirin and elective surgical procedures. Clin Cardiol 15 (1992) 709-710
59. Scher K.S. Unplanned reoperation for bleeding. Am Surg 62 (1996) 52-55
60. Speechley J.A., and Rugman F.P. Some problems with anticoagulants in dental surgery. Dent Update 19 (1992) 204-206
61. Samama C.M., Bastien O., Forestier F., Denninger M.H., Isetta C., Juliard J.M., et al. Antiplatelet agents in the perioperative period: expert recommendations of the French Society of Anesthesiology and Intensive Care (SFAR) 2001-summary statement. Can J Anaesth 49 (2002) S26-S35
62. Smout J., and Stansby G. Current practice in the use of antiplatelet agents in the peri-operative period by UK vascular surgeons. Ann R Coll Surg Engl 85 (2003) 97-101
63. Fijnheer R., Urbanus R.T., and Nieuwenhuis H.K. [Withdrawing the use of acetylsalicyclic acid prior to an operation usually not necessary]. Ned Tijdschr Geneeskd 147 (2003) 21-25 Dutch
64. Ferraris V.A., and Swanson E. Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. Surg Gynecol Obstet 156 (1983) 439-442
65. Patrono C., Garcia Rodriguez L.A., Landolfi R., and Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 353 (2005) 2373-2383
66. Di Micco B., Di Micco G., Niglio A., Romano M., and Di Micco P. Proximal deep venous thrombosis occurring after sudden clopidogrel suspension. Eur J Clin Pharmacol 60 (2004) 63-64