Clinicopathological analysis of hematological disorders in tube-fed patients with copper deficiency

Internal Medicine

Volumn 46, Issue 12, 2007, Pages 839-844

  Chen, Chun Chuan ^a   Takeshima, Fuminao ^a   Miyazaki, Takashige ^a   Murase, Kunihiko ^a   Ohtani, Hiroshi ^a   Isomoto, Hajime ^a   Shikuwa, Saburo ^a   Omagari, Katsuhisa ^a   Mizuta, Yohei ^a   Ozono, Yoshiyuki ^a   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Copper deficiency; Electron microscopy; Tube feeding

Indexed keywords

CERULOPLASMIN; COPPER; COPPER SULFATE; HEMOGLOBIN;

AGED; ANEMIA; ARTICLE; BONE MARROW CELL; BONE MARROW EXAMINATION; CELL VACUOLE; CERULOPLASMIN BLOOD LEVEL; CHRONIC PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; COPPER BLOOD LEVEL; COPPER DEFICIENCY; CYTOPENIA; CYTOPLASM; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; ELDERLY CARE; ELECTRON MICROSCOPY; ENTERIC FEEDING; ERYTHROID CELL; FEMALE; HEMATOLOGIC DISEASE; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LEUKOCYTE COUNT; LEUKOPENIA; MALE; MITOCHONDRION; STEM CELL; STOMACH TUBE; TUBE FEEDING;

AGED; AGED, 80 AND OVER; ANEMIA; BONE MARROW; CERULOPLASMIN; COPPER; DEFICIENCY DISEASES; DIETARY SUPPLEMENTS; ENTERAL NUTRITION; FEMALE; HUMANS; LEUKOPENIA; MALE; REFERENCE VALUES; TREATMENT OUTCOME;

EID: 34547900260     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.46.6264     Document Type: Article

References (30)

1. Grant MD, Rudberg MA, Brody JA. Gastrostomy placement and mortality among hospitalized Medicare beneficiaries. JAMA 279: 1973-1976, 1998.
2. Brant CQ, Stanich P, Ferrari AP Jr. Improvement of children's nutritional status after enteral feeding by PEG: an interim report. Gastrointest Endosc 50: 183-188, 1999.
3. Olivares M, Uauy R. Copper as an essential nutrient. Am J Clin Nutr 63: 791S-796S, 1996.
4. Kajiyama H, Murase K, Miyazaki T, et al. Micronutrient status and glutathione peroxidase in bedridden patients on tube feeding. J Int Med Res 29: 181-188, 2001.
5. Higuchi S, Higashi A, Nakamura T, Matsuda I. Nutritional copper deficiency in severely handicapped patients on a low copper enteral diet for a prolonged period: estimation of the required dose of dietary copper. J Pediatr Gastroenterol Nutr 7: 583-587, 1988.
6. Tamura H, Hirose S, Watanabe O, et al. Anemia and neutropenia due to copper deficiency in enteral nutrition. JPEN J Parenter Enteral Nutr 18: 185-189, 1994.
7. Nagano T, Toyoda T, Tanabe H, et al. Clinical features of hematological disorders caused by copper deficiency during long-term enteral nutrition. Intern Med 44: 554-559, 2005.
8. Dunlap WM, James GW, Hume DM. Anemia and neutropenia caused by copper deficiency. Ann Intern Med 80: 470-476, 1974.
9. Zidar BL, Shadduck RK, Zeigler Z, Winkelstein A. Observations on the anemia and neutropenia of human copper deficiency. Am J Hematol 3: 177-185, 1977.
10. Ruocco L, Baldi A, Cecconi N, et al. Severe pancytopenia due to copper deficiency. Case report. Acta Haematol 76: 224-226, 1986.
11. Simon SR, Branda RF, Tindle BF, Burns SL. Copper deficiency and sideroblastic anemia associated with zinc ingestion. Am J Hematol 28: 181-183, 1988.
12. Hirase N, Abe Y, Sadamura S, Yufu Y, et al. Anemia and neutropenia in a case of copper deficiency: role of copper in normal hematopoiesis. Acta Haematol 87: 195-197, 1992.
13. Hayton BA, Broome HE, Lilenbaum RC. Copper deficiency-induced anemia and neutropenia secondary to intestinal malabsorption. Am J Hematol 48: 45-47, 1995.
14. Gregg XT, Reddy V, Prehal JT. Copper deficiency masquerading as myelodysplastic syndrome. Blood 100: 1493-1495, 2002.
15. Kumar N, Elliott MA, Hoyer JD, Harper CM, Ahlskog JE, Phyliky RL. "Myelodysplasia," myeloneuropathy, and copper deficiency. Mayo Clin Proc 80: 943-946, 2005.
16. Dallman PR, Goodman JR. Enlargement of mitochondrial compartment in iron and copper deficiency. Blood 35: 496-505, 1970.
17. Williams DM, Loukopoulos D, Lee GR, Cartwright GE. Role of copper in mitochondrial iron metabolism. Blood 48: 77-85, 1976.
18. Cizewski-Culotta V, Gitlin JD. Disorders of copper metabolism. In: Metabolic and Molecular Bases of Inherited Disorders. 8th ed. Scriver CR, Beaudett AI, Sly WS, et al, Eds. McGraw-Hill, New York, 2001: 3105-3126.
19. Imes S, Pinchbeck BR, Dinwoodie A, Walker K, Thomson AB. Iron, folate, vitamin B-12, zinc, and copper status in outpatients with Crohn's disease: effect of diet counseling. J Am Diet Assoc 87: 928-930, 1987.
20. Spiegel JE, Willenbucher RF. Rapid development of severe copper deficiency in a patient with Crohn's disease receiving parenteral nutrition. JPEN J Parenter Enteral Nutr 23: 169-172, 1999.
21. Burnes JU, O'Keefe SJ, Fleming CR, Devine RM, Berkner S, Herrick L. Home parenteral nutrition - a 3-year analysis of clinical and laboratory monitoring. JPEN J Parenter Enteral Nutr 16: 327-332, 1992.
22. Forbes GM, Forbes A. Micronutrient status in patients receiving home parenteral nutrition. Nutrition 13: 941-944, 1997.
23. Yeung KY, Klug PP, Lessin LS. Alcohol-induced vacuolization in bone marrow cells: ultrastructure and mechanism of formation. Blood Cells 13: 487-502, 1988.
24. Rosenbach LM, Caviles AP, Mitus WJ. Chloramphenicol toxicity. Reversible vacuolization of erythroid cells. N Engl J Med 263: 724-728, 1960.
25. Pearson HA, Lobel JS, Kocoshis SA, et al. A new syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction. J Pediatr 95: 976-984, 1979.
26. Anderson AL, Lynch EC. Myelodyspoietic syndrome associated with diethylstilbestrol therapy. Arch Intern Med 140: 976-977, 1980.
27. Cordano A, Baertl JM, Graham GG. Copper deficiency in infancy. Pediatrics 34: 324-336, 1964.
28. Higuchi S, Higashi A, Nakamura T, Yanabe Y, Matsuda I. Antineutrophil antibodies in patients with nutritional copper deficiency. Eur J Pediatr 150: 327-330, 1991.
29. Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annu Rev Nutr 22: 439-458, 2002.
30. Williams DM. Copper deficiency in humans. Semin Hematol 20: 118-128, 1983.