Rapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 31, 2007, Pages 12807-12812

  Szklarczyk, Radek ^a,d   Heringa, Jaap ^a   Pond, Sergei Kosakovsky ^b   Nekrutenko, Anton ^c  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cancer evolution; CDKN2A; Overlapping protein coding regions; P53; Retinoblastoma protein

Indexed keywords

ARF PROTEIN; PROTEIN P16INK4A; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SUBSTITUTION; ARTICLE; CANCER; CARCINOGENESIS; EVOLUTION; EXON; GENE FUNCTION; GENE LOCUS; GENE MUTATION; HUMAN; MUTATION RATE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; CONSERVED SEQUENCE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EVOLUTION, MOLECULAR; EXONS; HUMANS; MAMMALS; OPEN READING FRAMES; PHYLOGENY; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34547895882     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0703238104     Document Type: Article

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