Synthesis of tetracyclic heterocompounds as selective estrogen receptor modulators. Part 2. Process improvement for scale-up of 2,5,8-substituted 11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta-[1,2-a]naphthalene derivatives

Organic Process Research and Development

Volumn 11, Issue 4, 2007, Pages 731-738

  Li, Xun ^a,b   Reuman, Michael ^a,b   Russell, Ronald K ^a,b   Youells, Scott ^a,b   Beish, Sandra ^a,b   Hu, Zhiyong ^a,b   Branum, Shawn ^a,b   Jain, Nareshkumar ^a,c   Sui, Zhihua ^a,c  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b High Output Synthesis ^*

^c Reproductive Therapeutics

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34547884640     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op700061x     Document Type: Article

References (17)

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3. (c) Jain, N.; Kanojia, R. M.; Xu, J.; Gou, J.-Z.; Pacia, E.; Lai, M.-T.; Du, F.; Musto, A.; Allan, G.; Hahn, D.; Lundeen, S.; Sui, Z. J. Med. Chem. 2006, 49, 3056.
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5. Kanojia, R. M.; Jain, N. F.; Ng, R.; Sui, Z.; Xu, J. WO2003053977, 2003.
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7. (b) Horváth, A.; De Smet, K.; Ormerod, D.; Depré, D.; Pérez-Balado, C.; Govaerts, T.; Van den Heuvel, D.; Schorpion, I. Org. Process Res. Dev. 2005, 9, 356.
8. Li, X.; Reuman, M.; Russell, R. K.; Adams, R.; Ma, R.; Beish, S.; Branum, S.; Youells, S.; Roberts, J.; Jain, N.; Kanojia, R.; Sui, Z. Org. Process Res. Dev. 2007, 11, 414-421, part 1 of this publication.
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