Impaired induction of adhesion molecule expression in immortalized endothelial cells leads to functional defects in dynamic interactions with lymphocytes

Journal of Investigative Dermatology

Volumn 127, Issue 9, 2007, Pages 2253-2258

  Oostingh, Gertie J ^a   Schlickum, Stephanie ^a   Friedl, Peter ^b   Schön, Michael P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MESSENGER RNA; SELECTIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL ADHESION; CELL IMMORTALIZATION; CELL INTERACTION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATION; LYMPHOCYTE ACTIVATION; MICROVASCULARIZATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROCESSING; SKIN CELL; TRANSCRIPTION REGULATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 34547854316     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700828     Document Type: Article

References (24)

1. Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC et al. (1992) HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 99:683-90
2. Bevilacqua MP, Nelson RM (1993) Selectins. J Clin Invest 91:379-87
3. Bevilacqua MP, Pober JS, Mendrick DL, Cotran RS, Gimbrone MA (1987) Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci USA 84:9238-42
4. Boehncke WH, Schön MP (2003) Interfering with leukocyte rolling-a promising therapeutic approach in inflammatory skin disorders? Trends Pharmacol Sci 24:49-52
5. Bonfanti R, Furie BC, Furie B, Wagner DD (1989) PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood 73:1109-12
6. Detmar M, Imcke E, Ruszczak Z, Orfanos CE (1990) Effects of recombinant tumor necrosis factor-alpha on cultured microvascular endothelial cells derived from human dermis. J Invest Dermatol 95:219S-22S
7. Ehrhardt C, Kneuer C, Bakowsky U (2004) Selectins - an emerging target for drug delivery. Adv Drug Deliv Rev 56:527-49
8. Greiffenberg L, Goebel W, Kim KS, Weiglein I, Bubert A, Engelbrecht F et al. (1998) Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: InlB-dependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells. Infect Immun 66:5260-7
9. Hohenwarter O, Zinser E, Schmatz C, Ruker F, Katinger H (1992) Influence of transfected SV40 early region on growth and differentiation of human endothelial cells. J Biotechnol 25:349-56
10. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M et al. (1999) Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 21:111-4
11. Kremlev SG, Palmer C (2005) Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures. J Neuroimmunol 162:71-80
12. Krump-Konvalinkova V, Bittinger F, Unger RE, Peters K, Lehr HA, Kirkpatrick CJ (2001) Generation of human pulmonary microvascular endothelial cell lines. Lab Invest 81:1717-27
13. Lassalle P, LaGrou C, Delneste Y, Sanceau J, Coll J, Torpier G et al. (1992) Human endothelial cells transfected by SV40T antigens: characterization and potential use as a source of normal endothelial factors. Eur J Immunol 22:425-31
14. Matsumura T, Takesue M, Westerman KA, Okitsu T, Sakaguchi M, Fukazawa T et al. (2004) Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT. Transplantation 77:1357-65
15. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84:92-9
16. Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS et al. (1999) Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 21:115-8
17. Nisato RE, Harrison JA, Buser R, Orci L, Rinsch C, Montesano R et al. (2004) Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span. Am J Pathol 165:11-24
18. Oostingh GJ, Ludwig RJ, Enders S, Grüner S, Harms G, Boehncke WH et al. (2007) Diminished lymphocyte adhesion and alleviation of allergic responses by small-molecule- or antibody-mediated inhibition of L-selectin functions. J Invest Dermatol. 127:90-7
19. Schön MP, Ludwig RJ (2005) Lymphocyte trafficking to inflamed skin - molecular mechanisms and implications for therapeutic target molecules. Expert Opin Ther Targets 9:225-43
20. Schön MP, Zollner TM, Boehncke WH (2003) The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders. J Invest Dermatol 121:951-62
21. Schütz M, Teifel M, Friedl P (1997) Establishment of a human placental endothelial cell line with extended life span after transfection with SV 40 T-antigens. Eur J Cell Biol 74:315-20
22. Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M (2002) Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. Exp Cell Res 273:21-33
23. Vicart P, Testut P, Schwartz B, Llorens-Cortes C, Perdomo JJ, Paulin D (1993) Cell adhesion markers are expressed by a stable human endothelial cell line transformed by the SV40 large T antigen under vimentin promoter control. J Cell Physiol 157:41-51
24. Xu Y, Swerlick RA, Sepp N, Bosse D, Ades EW, Lawley TJ (1994) Characterization of expression and modulation of cell adhesion molecules on an immortalized human dermal microvascular endothelial cell line (HMEC-1). J Invest Dermatol 102:833-7