Randomized-controlled trial of esomeprazole in functional dyspepsia patients with epigastric pain or burning: Does a 1-week trial of acid suppression predict symptom response?

Alimentary Pharmacology and Therapeutics

Volumn 26, Issue 5, 2007, Pages 673-682

  Talley, N J ^a,b,h   Vakil, N ^c   Lauritsen, K ^d   Van Zanten, S V ^e   Flook, N ^f   Bolling Sternevald, E ^g   Persson, T ^g   Bjorck E ^g   Lind, T ^g  

^a Mayo Clinic   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

^e DALHOUSIE UNIVERSITY   (Canada)

^f UNIVERSITY OF ALBERTA   (Canada)

^g ASTRAZENECA R AND D   (Sweden)

^h MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESOMEPRAZOLE; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DYSPEPSIA; EPIGASTRIC BURNING; EPIGASTRIC PAIN; FEMALE; HUMAN; MALE; MULTICENTER STUDY; PREDICTIVE VALIDITY; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; STOMACH ACID; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; AGED; ANTI-ULCER AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSPEPSIA; FEMALE; FOLLOW-UP STUDIES; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; MALE; MIDDLE AGED; OMEPRAZOLE; PLACEBOS; QUALITY OF LIFE; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 34547852248     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2007.03410.x     Document Type: Article

References (18)

1. Talley NJ, Vakil N, Moayyedi P. AGA Technical review on the evaluation of dyspepsia. Gastroenterology 2005 129:1756 80.
2. El-Serag HB, Talley NJ. Systematic review: health-related quality of life in functional dyspepsia. Aliment Pharmacol Ther 2003 18:387 93.
3. Anonymous. Endoscopy in the evaluation of dyspepsia. Health and Public Policy Committee, American College of Physicians. Ann Intern Med 1985 102:266 9.
4. Moayyedi P, Delaney B, Vakil N, Forman D, Talley NJ. The efficacy of proton pump inhibitors in non-ulcer dyspepsia: a systematic review and economic analysis. Gastroenterology 2004 127:1329 37.
5. Talley NJ, Meineche-Schmidt V, Pare P, et al. Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). Aliment Pharmacol Ther 1998 12:1055 65.
6. Altman DG, Bland JM. Diagnostic tests: 1. Sensitivity and specificity. BMJ 1994 308:1552.
7. Talley NJ, Vakil N. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol 2005 100:2324 37.
8. Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology 2006 130:1466 79.
9. Bytzer P, Talley NJ. Dyspepsia. Ann Intern Med 2001 134:815 22.
10. Moayyedi P, Talley NJ, Fennerty MB, Vakil N. Can the clinical history distinguish between organic and functional dyspepsia? JAMA 2006 295:1566 76.
11. Veldhuyzen van Zanten SJ, Talley NJ, Bytzer P, Klein KB, Whorwell PJ, Zinsmeister AR. Design of treatment trials for functional gastrointestinal disorders. Gut 1999 45 (Suppl. 2 II69 77.
12. Talley NJ, Locke GR, Lahr BD, et al. Predictors of the placebo response in functional dyspepsia. Aliment Pharmacol Ther 2006 23:923 36.
13. Numans ME, Lau J, de Wit NJ, Bonis PA. Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med 2004 140:518 27.
14. Cremonini F, Wise J, Moayyedi P, Talley NJ. Diagnostic and therapeutic use of proton pump inhibitors in non-cardiac chest pain: a metaanalysis. Am J Gastroenterol 2005 100:1226 32.
15. Peura DA, Kovacs TOG, Metz DC, Siepman N, Pilmer BL, Talley NJ. Lansoprazole in the treatment of functional dyspepsia: two double blind, randomized, placebo-controlled trials. Am J Med 2004 116:740 8.
16. Vakil N, Veldhuyzen van Zanten SV, Kahrilas P, Dent J, Jones R. Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006 101:1900 20.
17. Agreus L. Natural history of dyspepsia. Gut 2002 50 (Suppl. IV iv2 9.
18. Malfertheiner P, Lind T, Willich S, et al. Prognostic influence of Barrett's oesophagus and Helicobacter pylori infection on healing of erosive gastro-oesophageal reflux disease (GORD) and symptom resolution in non-erosive GORD: report from the ProGORD study. Gut 2005 54:746 51.