Decreased bone strength in HLA-B27 transgenic rat model of spondyloarthropathy

Rheumatology

Volumn 46, Issue 8, 2007, Pages 1258-1262

  Akhter, M P ^a   Jung, L K L ^a  

^a Children's Hospital Omaha   (United States)

Author keywords

Bone; Bone strength; Femur; Spondyloarthropathy; Stiffness; Transgenic rat; Vertebral body

Indexed keywords

HLA B27 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE FRAGILITY; BONE STRENGTH; BONE STRUCTURE; CONTROLLED STUDY; FEMUR; FEMUR NECK; FEMUR SHAFT; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOPENIA; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; RIGIDITY; SPINE; SPONDYLOARTHROPATHY; TRANSGENIC MOUSE; VERTEBRA BODY; YOUNG MODULUS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; COMPRESSIVE STRENGTH; DISEASE MODELS, ANIMAL; ELASTICITY; FEMUR; HLA-B27 ANTIGEN; LUMBAR VERTEBRAE; MALE; OSTEOPOROSIS; RATS; SPONDYLARTHROPATHIES; STRESS, MECHANICAL;

EID: 34547840157     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kem104     Document Type: Article

References (28)

1. Yu D. Spondyloarthropathies. Philadelphia, PA: W.B. Saunders Co., 2003.
2. El Maghraoui A, Do Santos Zounon AA, Jroundi I et al. Reproducibility of bone mineral density measurements using dual X-ray absorptiometry in daily clinical practice. Osteoporos Int 2005;16(12):1742-8.
3. Gilgil E, Kacar C, Tuncer T, Butun B. The association of syndesmophytes with vertebral bone mineral density in patients with ankylosing spondylitis. J Rheumatol 2005;32:292-4.
4. Karberg K, Zochling J, Sieper J, Felsenberg D, Braun J. Bone loss is detected more frequently in patients with ankylosing spondylitis with syndesmophytes. J Rheumatol 2005;32:1290-8.
5. Sampaio-Barros PD, Filardi S, Samara AM, Marques-Neto JF. Prognostic factors of low bone mineral density in ankylosing spondylitis. Clin Rheumatol 2005;24:310-1.
6. Wendling D. Bone loss in ankylosing spondylitis: Can we put the puzzle together? J Rheumatol 2005;32:1184-5.
7. Franck H, Meurer T, Hofbauer LC. Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis. J Rheumatol 2004;31:2236-41.
8. Lange U, Kluge A, Strunk J, Teichmann J, Bachmann G. Ankylosing spondylitis and bone mineral density-what is the ideal tool for measurement? Rheumatol Int 2004;26(2):115-20.
9. Toussirot E, Michel F, Wendling D. Bone density, ultrasound measurements and body composition in early ankylosing spondylitis. Rheumatology 2001;40:882-8.
10. Aerssens J, Van Audekercke R, Talalaj M et al. Effect of 1 alpha-vitamin D3 on bone strength and composition in growing rats with and without corticosteroid treatment. Calcif Tissue Int 1994;55:443-50.
11. Khan MA, van der Linden SM, Kushner I, Valkenburg HA, Cats A. Spondylitic disease without radiologic evidence of sacroiliitis in relatives of HLA-B27 positive ankylosing spondylitis patients. Arthritis Rheum 1985;28:40-3.
12. Gran JT, Skomsvoll JF. The outcome of ankylosing spondylitis: A study of 100 patients. Br J Rheumatol 1997;36:766-71.
13. Will R, Palmer R, Bhalla AK, Ring F, Calin A. Osteoporosis in early ankylosing spondylitis: A primary pathological event? Lancet 1989;2:1483-5.
14. Toussirot E, Picard Blum S, Dumoulin G, Cedoz JP, Wendling D. Relationship between urinary pyridinium cross-links, disease activity and disease subsets of ankylosing spondylitis. Rheumatology 1999;38:21-7.
15. Gratacos J, Collado A, Pons F et al. Significant loss of bone mass in patients with early, active ankylosing spondylitis: A followup study. Arthritis Rheum 1999;42:2319-24.
16. Taurog JD, Maika SD, Satumtira N et al. Inflammatory disease in HLA-B27 transgenic rats. Immunol Rev 1999;169:209-23.
17. May NY, Tatakis DN. Accelerated alveolar bone loss in male HLA-B27 transgenic rats: Adult onset. J Periodontal Res 2004;39:33-6.
18. Tatakis DN, Guglielmoni P, Fletcher HM. Accelerated alveolar bone loss in HLA-b27 transgenic rats: An adult onset condition. J Rheumatol 2002;29:1244-51.
19. Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: An animal model of KLA-B27-associated human disorders. Cell 1990;63:1099-112.
20. Taurog JD, Maika SD, Simmons WA, Breban M, Hammer RE. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. J Immunol 1993;150:4168-78.
21. Akhter MP, Wells DJ, Short SJ et al. Bone biomechanical properties in LRP5 mutant mice. Bone 2004,35:162-9.
22. Akhter MP, Cullen DM, Gong G, Recker RR. Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice. Bone 2001; 29:121-5.
23. Akhter MP, Iwaniec UT, Covey MA, Cullen DM, Kimmel DB, Recker RR. Genetic variations in bone density, histomorphometry, and strength in mice. Calcif Tissue Int 2000;67:337-44.
24. Akpe MP, Waibel PE, Larntz K, Metz AL, Noll SL, Walser MM. Phosphorus availability bioassay using bone ash and bone densitometry as response criteria. Poult Sci 1987;66:713-20.
25. Ralston SH, Fraser WD, Jankowski J et al. Hypercalcaemia in rheumatoid arthritis revisited. Ann Rheum Dis 1990;49:22-4.
26. Akhter MP, Fan Z, Rho JY. Bone intrinsic material properties in three inbred mouse strains. Calcif Tissue Int 2004;75:416-20.
27. Rho JY, Roy ME 2nd, Tsui TY, Pharr GM. Elastic properties of micro-structural components of human bone tissue as measured by nanoindentation. J Biomed Meter Res 1999;45:48-54.
28. Tran TM, Dorris ML, Satumtira N et al. Additional human beta(2)-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheum 2006;54:1317-27.