Midregional proadrenomedullin reflects cardiac dysfunction in haemodialysis patients with cardiovascular disease

Nephrology Dialysis Transplantation

Volumn 22, Issue 8, 2007, Pages 2263-2268

  Yoshihara, Fumiki ^a,d   Ernst, Andrea ^b   Morgenthaler, Nils G ^c   Horio, Takeshi ^a   Nakamura, Satoko ^a   Nakahama, Hajime ^a   Nakata, Hiroto ^a   Bergmann, Andreas ^b,c   Kangawa, Kenji ^a   Kawano, Yuhei ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b SPHINGOTEC GMBH   (Germany)

^c BRAHMS AG   (Germany)

^d NONE   (Japan)

Author keywords

Cardiac dysfunction; Excessive blood volume; Haemodialysis; Midregional proadrenomedullin; Systemic inflammatory status

Indexed keywords

C REACTIVE PROTEIN; PROADRENOMEDULLIN;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BLOOD VOLUME; BODY WEIGHT; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIASTOLE; DOPPLER ECHOCARDIOGRAPHY; FEMALE; HEART DISEASE; HEART LEFT VENTRICLE EJECTION FRACTION; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; INFERIOR CAVA VEIN; INFLAMMATION; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PULMONARY VEIN; REGRESSION ANALYSIS; SYSTOLE; TWO DIMENSIONAL ECHOCARDIOGRAPHY; ULTRAFILTRATION; VEIN BLOOD FLOW; VEIN DIAMETER;

AGED; BLOOD VOLUME; BODY WEIGHT; C-REACTIVE PROTEIN; ECHOCARDIOGRAPHY; FEMALE; HEART DISEASES; HUMANS; INFLAMMATION; KIDNEY DISEASES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; PROTEINS; RENAL DIALYSIS;

EID: 34547839677     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm029     Document Type: Article

References (20)

1. United States Renal Data System. Causes of death. Am J Kidney Dis 1997; 30 [Suppl 1]: S107-S117
2. Stegmayr BG. Ultrafiltration and dry weight-What are the cardiovascular effect? Artif Organs 2003; 27: 227-229
3. deFilippi C, Wasserman S, Rosanio S et al. Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis. JAMA 2000; 290: 353-359
4. Nishikimi T, Saito Y, Kitamura K et al. Increased plasma levels of adrenomedullin in patients with heart failure. J Am Coll Cardiol 1995; 26: 1424-1431
5. Miyao Y, Nishikimi T, Goto Y et al. Increased plasma adrenomedullin levels in patients with acute myocardial infarction in proportion to the clinical severity. Heart 1998; 79: 39-44
6. Suzuki Y, Horio T, Hayashi T et al. Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation. Regul Pept 2004; 118: 99-104
7. Cases A, Esforzado N, Lario S et al. Increased plasma adrenomedullin levels in hemodialysis patients with sustained hypotension. Kidney Int 2000; 57: 664-670
8. Mallamaci F, Zoccali C, Parlongo S, Cutrupi S, Tripepi G, Postorino M. Plasma adrenomedullin during acute changes in intravascular volume in hemodialysis patients. Kidney Int 1998; 54: 1697-1703
9. Yoshihara F, Horio T, Nakamura S et al. Adrenomedullin reflects cardiac dysfunction, excessive blood volume, and inflammation in hemodialysis patients. Kidney Int 2005; 68: 1355-1363
10. Meeran K, O'Shea D, Upton PD et al. Circulating adreno-medullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans: A pharmacokinetic study. J Clin Endocrinol Metab 1997; 82: 95-100
11. Pio R, Martinez A, Unsworth EJ et al. Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners. J Biol Chem 2001; 276: 12292-12300
12. Kitamura K, Sakata J, Kangawa K, Kojima M, Matsuo H, Eto T. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem Biophys Res Commun 1993; 194: 720-725
13. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Measurement of midregional proadrenomedullin mi plasma with an immunoluminometric assay. Clin Chem 2005; 51: 1823-1829
14. Rakowski H, Appleton C, Chan KL et al. Canadian consensus recommendations for the measurement and reporting of diastolic dysfunction by echocardiography: From the investigators of consensus on diastolic dysfunction by echocardiography. J Am Soc Echocardiogr 1996; 9: 736-760
15. Forfia PR, Watkins SP, Rame JE, Stewart KJ, Shapiro EP. Relationship between B-type natriuretic peptides and pulmonary capillary wedge pressure in the intensive care unit. J Am Coll Cardiol 2005; 45: 1667-1671
16. Lu X, Zhao JB, Wang GR, Gregersen H, Kassab GS. Remodeling of the zero-stress state of femoral arteries in response to flow overload. Am J Physiol Heart Circ Physiol 2001; 280: H1547-H1559
17. Yoshihara F, Nishikimi T, Horio T et al. Ventricular adrenomedullin concentration is a sensitive biochemical marker for volume and pressure overload in rats. Am J Physiol Heart Circ Physiol 2000; 278: H633-H642
18. Chun TH, Itoh H, Ogawa Y et al. Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension 1997; 29: 1296-1302
19. Kubo A, Minamino N, Isumi Y et al. Production of adrenomedullin in macrophage cell line and peritoneal macrophage. J Biol Chem 1998; 273: 16730-16738
20. Christ-Crain M, Morgenthaler NG, Struck J, Harbarth S, Bergmann A, Muller B. Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: An observational study. Crit Care 2005; 9: R816-R824