5-HT3 receptor antagonists regulate autonomic cardiac dysfunction in primary fibromyalgia syndrome

Rheumatology International

Volumn 27, Issue 11, 2007, Pages 1025-1030

  Seidel, Matthias F ^a   Weinreich, Gunter F ^b   Stratz, Thomas ^a   Müller, Wolfgang ^c  

^a Medizinische Universitäts Poliklink ^*  (Germany)

^b Institut für Arbeits und Sozialhygiene Stiftung   (Germany)

^c Rheumatologische Forschungsabteilung   (Germany)

Author keywords

Cardiac dysfunction; Fibromyalgia; Tropisetron

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; SEROTONIN 3 ANTAGONIST; TROPISETRON;

ARTICLE; CHOLINERGIC SYSTEM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FIBROMYALGIA; HEART DISEASE; HUMAN; MAJOR CLINICAL STUDY; NOCICEPTION; PAIN; PHYSIOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RR INTERVAL; SPECTROSCOPY; SYMPATHETIC TONE;

ADULT; ARRHYTHMIAS, CARDIAC; AUTONOMIC NERVOUS SYSTEM; COMBINED MODALITY THERAPY; FEMALE; FIBROMYALGIA; HEART RATE; HUMANS; INDOLES; MIDDLE AGED; PAIN MEASUREMENT; PHYSICAL THERAPY MODALITIES; SEROTONIN ANTAGONISTS; SEVERITY OF ILLNESS INDEX;

EID: 34547839636     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-007-0406-6     Document Type: Article

References (23)

1. Müller W, Lautenschläger J (1990) Generalized tendomyopathy II: pathogenesis and therapy. Z Rheumatol 49:22-29
2. Martínez Lavín M, Hermosillo AG (2000) Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia. Semin Arthritis Rheum 29:197-199
3. Cohen H, Neumann L, Shore M, Amir M, Cassuto Y, Buskila D (2000) Autonomic dysfunction in patients with fibromyalgia: application of power spectral analysis of heart rate variability. Semin Arthritis Rheum 29:217-227
4. Lang E, Caminal P, Horvath G, Jane R, Vallverdu M, Slezsak J, Bayes de Luna A (1998) Spectral analysis of the heart period variance (HVP): a tool to stratify risk following myocardial infarction. J Med Eng Technol 22:248-256
5. Haus U, Varga B, Stratz T, Späth M, Müller W (2000) Oral treatment of fibromyalgia with tropisetron given over 28 days: influence on functional and vegetative symptoms, psychometric parameters and pain. Scand J Rheumatol Suppl 113:55-58
6. Müller W, Stratz T (2000) The use of 5-HT3 receptor antagonists in various rheumatic diseases: a clue to the mechanism of action of these agents in fibromyalgia. Scand J Rheumatol Suppl 113:66-71
7. Färber L, Stratz TH, Bruckle W, Späth M, Pongratz D, Lautenschläger J, Kotter I, Zoller B, Peter HH, Neeck G, Welzel D, Müller W, German Fibromyalgia Study Group (2001) Short-term treatment of primary fibromyalgia with the 5-HT3-receptor antagonist tropisetron. Results of a randomized, double-blind, placebo-controlled multicenter trial in 418 patients. Int J Clin Pharmacol Res 21:1-13
8. Späth M, Stratz T, Neeck G, Kotter I, Hammel B, Amberger CC, Haus U, Färber L, Pongratz D, Müller W (2004) Efficacy and tolerability of intravenous tropisetron in the treatment of fibromyalgia. Scand J Rheumatol 33:267-270
9. Seidel MF, Koch FW, Vetter H (2006) Macrophage like synoviocytes display phenotypic polymorphisms in a serum free tissue culture medium. Rheumatol Int 26:244-251
10. Seidel MF, Ulrich Merzenich G, Fiebich B, Candelario Jalil E, Koch FW, Vetter H (2004) Tropisetron inhibits serotonin-induced PGE2 release from macrophage-like synovial cells in serum-free tissue culture. Scand J Rheumatol Suppl 119:33
11. Fiebich BL, Akundi RS, Lieb K, Candelario Jalil E, Gmeiner D, Haus U, Müller W, Stratz T, Munoz E (2004) Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide stimulated primary human monocytes. Scand J Rheumatol Suppl 119:28-32
12. Samborski W, Atarowska M, Stratz T et al (2003) Intraarticular tropisentron compared with ethylprednisolone acetate in knee involvement in osteoarthritis and rheumatiod arthritis. Preliminary report. Ann Rheum Dis 62:405
13. Voog U, Alstergren P, Leibur E, Kallikorm R, Kopp S (2004) Influence of serotonin on the analgesic effect of granisetron on temporomandibular joint arthritis. Mediators Inflamm 13:373-376
14. Wolfe F, Smythe HA, Yunus MB, Bennett RM et al (1990) The american college of rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum 33:160-172
15. Lautenschläger J, Seglias J, Bruckle W, Müller W (1991) Comparisons of spontaneous pain and tenderness in patients with primary fibromyalgia. Clin Rheumatol 10:168-173
16. Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ (1981) Spectrum analysis of heart rate fluctuation: a quantitative probe of beat to beat cardiovascular control. Science 10:220-222
17. Lang E, Szilagyi N (1991) Significance and assessment of autonomic indices in cardiovascular reactions. Acta Physiol Hung 78:241-260
18. Izso L, Lang E (2000) Heart period variability as mental effort monitor in human computer interaction. Behav Inf Technol 19:297-306
19. Kelemen J, Trocsanyi M, Lang E, Müller W (2000) The effect of whole body cold treatment on the autonomic nervous system studied by power spectral analysis of heart period variance. J Musculoskelet pain 6:136
20. Kelemen J, Lang E, Balint G, Trocsanyi M, Müller W (1998) Orthostatic sympathetic derangement of baroreflex in patients with fibromyalgia. J Rheumatol 25:823-825
21. Martinez Lavin M, Hermosillo AG, Rosas M, Soto ME (1998) Circadian studies of autonomic nervous balance in patients with fibromyalgia: a heart rate variability analysis. Arthritis Rheum 41:1966-1971
22. Furlan R, Colombo S, Perego F, Atzeni F, Diana A, Barbic F, Porta A, Pace F, Malliani A, Sarzi Puttini P (2005) Abnormalities of cardiovascular neural control and reduced orthostatic tolerance in patients with primary fibromyalgia. J Rheumatol 32:1787-1793
23. Müller W, Lautenschläger J (1990) Generalized tendomyopathy I: clinical aspects, follow up and differential diagnosis. Z Rheumatol 49:11-21