Treatment of hyponatraemia by urea decreases risks of brain complications in rats. Brain osmolyte contents analysis

Nephrology Dialysis Transplantation

Volumn 22, Issue 7, 2007, Pages 1856-1863

  Soupart, Alain ^a,b   Schroëder, Barbara ^c   Decaux, Guy ^b,d  

^a Jolimont/Tubize Nivelles Hospital   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d ERASME HOSPITAL   (Belgium)

Author keywords

Brain; Hyponatraemia; Osmotic demyelinating syndrome; Urea

Indexed keywords

4 AMINOBUTYRIC ACID; ALANINE; AMINO ACID; ASPARTIC ACID; BETAINE; CREATINE; GLUTAMIC ACID; GLUTAMINE; GLYCEROPHOSPHORYLCHOLINE; GLYCINE; INOSITOL; ISOLEUCINE; LYSINE; METHIONINE; ORNITHINE; PHENYLALANINE; PHOSPHOETHANOLAMINE; POTASSIUM ION; PROLINE; SERINE; SODIUM; SODIUM ION; THREONINE; TRYPTOPHAN; TYROSINE; UREA; VALINE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; BRAIN PROTECTION; BRAIN WATER; CONTROLLED STUDY; DEMYELINATING DISEASE; DIURESIS; DRUG RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPONATREMIA; MALE; MORTALITY; NEUROLOGIC DISEASE; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SODIUM BLOOD LEVEL; SYMPTOMATOLOGY; UREA BLOOD LEVEL; WATER CONTENT;

ANIMALS; BETAINE; BODY WATER; BRAIN; BRAIN DISEASES; DEMYELINATING DISEASES; ELECTROLYTES; HYPONATREMIA; MALE; RATS; RATS, WISTAR; SODIUM; UREA;

EID: 34547830282     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm138     Document Type: Article

References (27)

1. Soupart A, Decaux G. Therapeutic recommendations for management of severe hyponatremia: Current concepts on pathogenesis and prevention of neurologic complications. Clin Nephrol 1996; 46: 149-169
2. Soupart A, Stenuit A, Perier O, Decaux G. Limits of brain tolerance to daily increments in serum sodium in chronically hyponatremic rats treated with hypertonic saline or urea: Advantage of urea. Clin Sci 1991; 80: 77-84
3. Decaux G. Long-term treatment of patients with inappropriate secretion of ADH by vasopressin receptor antagonist conivaptan, urea or furosemide. Am J Med 2001; 110: 582-584
4. Decaux G, Soupart A. Treatment of symptomatic hyponatremia. Am J Med Sci 2003; 326: 1-6
5. Oo TN, Smith CL, Swan SK. Does uremia protect against the demyelination associated with correction of hyponatremia during hemodialysis? A case report and literature review. Semin Dial 2003; 16: 68-71
6. Verbalis JG, Gullans SR. Rapid correction of hyponatremia produces differential effects on brain osmolyte reaccumulation in rats. Brain Res 1993; 106: 19-27
7. Soupart A, Penninckx R, Stenuit A, Perier O, Decaux G. Treatment of chronic hyponatremia in rats by intravenous saline: Comparison of rate versus magnitude of correction. Kidney Int 1992; 41: 1662-1667
8. Soupart A, Penninckx R, Stenuit A, Decaux G. Azotemia (48 h) decreases the risk of brain damage in rats after correction of chronic hyponatremia. Brain Res 2000; 852: 167-172
9. Soupart A, Silver S, Schroëder B, Sterns R, Decaux G. Rapid (24h) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. J Am Soc Nephrol 2002; 13: 1433-1441
10. Woo SK, Dahl SC, Handler JS, Kwon HM. Bidirectional regulation of tonicity-responsive enhancer binding protein in response to change in tonicity. Am J Physiol 2000; 278: F1006-F1012
11. Wolff SD, Yancez PH, Stanton TS, Balaban RS. A simple HPLC method for quantitating major organic solutes of renal medulla. Am J Physiol 1989; 256: F954-F956
12. Gunawan S, Walton NY, Treitman DM. High-performance liquid chromatography determination of selected amino acids in rat brain by precolumn derivatization with phenylisothiocyanate. J Chromatogr 1990; 503: 177-187
13. Karp BI, Laureno R. Pontine and extrapontine myelinolysis: A neurologic disorder following rapid correction of hyponatremia. Medicine (Baltimore) 1993; 72: 359-373
14. Laureno R, Illowski B. Myelinolysis after correction of hyponatremia. Ann Int Med 1997; 126: 57-62
15. Oh MS, Kim HJ, Caroll MJ. Recommendations for treatment of symptomatic hyponatremia. Nephron 1996; 70: 143-150
16. Miyazaki T, Yamamura Y, Onogawa T et al. Therapeutic effects of Tolvaptan, a potent selective non-peptide vasopressin V2-receptors antagonist in rats with acute and chronic severe hyponatremia. Endocrinology 2005; 146: 3037-3043
17. Verbalis JG, Martinez AJ. Correction of chronic hyponatremia with a vasopressin-receptor antagonist is associated with brain myelinolysis in rats. Clin Res 1989; 37: 586A (abstract)
18. Soupart A, Silver S, Schroeder B, Sterns R, Decaux G. Comparison of mortality and brain composition in hyponatremic rats treated with vasopressin V1-V2 receptor antagonists or water diuresis. J Am Soc Nephrol 2003; 14: 747A
19. Soupart A, Gross P, Legros JJ et al. Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with Satavaptan (SR121463B), an orally active non-peptide vasopressin V2-receptor antagonist. Clin J Am Soc Nephrol 2006; 1: 1154-1160
20. Horio M, Ito A, Matsuoka Y et al. Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: Protective effect of Betaine. Nephrol Dial Transplant 2001; 16: 483-490
21. Silver SM, Schroëder BM, Sterns RH, Rojiani M. Myoinositol administration improves survival and reduces myelinolysis after rapid correction of hyponatremia in rats. J Neuropathol Exp Neurol 2006; 65: 37-44
22. De Luca GC, Nagy ZS, Esiri MM, Davey P. Evidence for a role for apoptosis in central pontine myelinolysis. Acta Neuropathol 2002; 103: 590-598
23. Adler S, Martinez AJ, Williams DS, Verbalis J. Positive association between blood-brain-barrier disruption and osmotically-induced demyelination. Multiple Sclerosis 2000; 6: 24-31
24. Silver SM, Desimone JA, Smith DA, Sterns RM. Dialysis disequilibrium syndrome (ODS) in rats: Role of the 'reverse urea effect'. Kidney Int 1992; 42: 161-166
25. Hu MC, Bankir L, Michelet S, Rousselet G, Trinh-Trang-Tan MM. Massive reduction of urea transporters in remnant kidney and brain of uremic rats. Kidney Int 2000; 58: 1202-1210
26. Santos BC, Chevaile A, Hebert MJ, Zagajeski J, Gullans SR. A combination of NaCl and Urea enhances survival of IMCD cells to hyperosmolality. Am J Physiol 1998; 274: F1167-F1173
27. Wang X, Wu L, Aouffen M, Mateescu MA, Nadeau R, Wang R. Novel cardiac protective effects of urea: From shark to rat. Br J Pharmacol 1999; 128: 1477-1484