메뉴 건너뛰기




Volumn 102, Issue 9, 2007, Pages 1432-1442

Levo-alpha-acetylmethadol (LAAM) versus methadone maintenance: 1-Year treatment retention, outcomes and status

Author keywords

Clinical trials; Drug abuse treatment outcomes; LAAM maintenance; Methadone maintenance; Narcotic replacement therapy; Opiate addiction; Retention

Indexed keywords

LEVACETYLMETHADOL; METHADONE; OPIATE;

EID: 34547829548     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/j.1360-0443.2007.01935.x     Document Type: Article
Times cited : (21)

References (44)
  • 1
    • 34547844866 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration (FDA) Talk Paper T93-36. FDA Announces LAAM Approved to Treat Drug Dependence. (August 3, 1993). Available at: (accessed 15 March 2006).
    • U.S. Food and Drug Administration (FDA) Talk Paper T93-36. FDA Announces LAAM Approved to Treat Drug Dependence. (August 3, 1993). Available at: http://www.fda.gov/bbs/topics/ANSWERS/ANS00517.html (accessed 15 March 2006).
  • 2
    • 34547844864 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration (FDA) Talk Paper T02-38. FDA Announces Subutex and Suboxone Approved to Treat Opiate Dependence (October 8, 2002). Available at: (accessed 15 March 2006).
    • U.S. Food and Drug Administration (FDA) Talk Paper T02-38. FDA Announces Subutex and Suboxone Approved to Treat Opiate Dependence (October 8, 2002). Available at: http://www.fda.gov/bbs/topics/ANSWERS/2002/ANS01165.html (accessed 15 March 2006).
  • 4
    • 0019789738 scopus 로고
    • A comparison of thrice weekly LAAM and daily methadone in employed opiate addicts
    • Freedman R. R., Czertko G. A comparison of thrice weekly LAAM and daily methadone in employed opiate addicts. Drug Alcohol Depend 1981 8 : 215 22.
    • (1981) Drug Alcohol Depend , vol.8 , pp. 215-22
    • Freedman, R.R.1    Czertko, G.2
  • 5
    • 0014951238 scopus 로고
    • Comparison of acetylmethadol and methadone in the treatment of long-term heroin users
    • Jaffe J. H., Schuster C. R., Smith B. B., Blachley P. H. Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. JAMA 1970 211 : 1834 6.
    • (1970) JAMA , vol.211 , pp. 1834-6
    • Jaffe, J.H.1    Schuster, C.R.2    Smith, B.B.3    Blachley, P.H.4
  • 6
    • 0015412759 scopus 로고
    • Methadyl acetate versus methadone: A double-blind study in opiate users
    • Jaffe J. H., Senay E. C., Schuster C. R., Renault P. R. Methadyl acetate versus methadone: a double-blind study in opiate users. JAMA 1972 222 : 437 42.
    • (1972) JAMA , vol.222 , pp. 437-42
    • Jaffe, J.H.1    Senay, E.C.2    Schuster, C.R.3    Renault, P.R.4
  • 8
    • 0017140115 scopus 로고
    • Methadyl acetate and methadone as maintenance treatments for opiate addicts
    • Ling W., Charuvastra V. C., Kaim S. C., Klett C. J. Methadyl acetate and methadone as maintenance treatments for opiate addicts. Arch Gen Psychiatry 1976 33 : 709 20.
    • (1976) Arch Gen Psychiatry , vol.33 , pp. 709-20
    • Ling, W.1    Charuvastra, V.C.2    Kaim, S.C.3    Klett, C.J.4
  • 9
    • 0018094962 scopus 로고
    • A cooperative clinical study of methadyl acetate 1. Three-times-a-week regimen
    • Ling W., Klett J., Gillis R. D. A cooperative clinical study of methadyl acetate 1. Three-times-a-week regimen. Arch Gen Psychiatry 1978 35 : 345 53.
    • (1978) Arch Gen Psychiatry , vol.35 , pp. 345-53
    • Ling, W.1    Klett, J.2    Gillis, R.D.3
  • 11
    • 0017330308 scopus 로고
    • Methadyl acetate and methadone: An open comparison
    • Senay E. C., Dorus W., Renault P. F. Methadyl acetate and methadone: an open comparison. JAMA 1977 237 : 138 42.
    • (1977) JAMA , vol.237 , pp. 138-42
    • Senay, E.C.1    Dorus, W.2    Renault, P.F.3
  • 12
    • 0017854312 scopus 로고
    • Acceptability of methadyl acetate (LAAM) as compared with methadone in a treatment program for opiate addicts
    • Trueblood B., Judson B. A., Goldstein A. Acceptability of methadyl acetate (LAAM) as compared with methadone in a treatment program for opiate addicts. Drug Alcohol Depend 1978 3 : 125 32.
    • (1978) Drug Alcohol Depend , vol.3 , pp. 125-32
    • Trueblood, B.1    Judson, B.A.2    Goldstein, A.3
  • 14
    • 0020041648 scopus 로고
    • Withdrawal from heroin in three or six weeks-comparison of methadyl acetate and methadone
    • Sorenson J. L., Hargreaves W. A., Weinberg J. A. Withdrawal from heroin in three or six weeks-comparison of methadyl acetate and methadone. Arch Gen Psychiatry 1982 39 : 167 71.
    • (1982) Arch Gen Psychiatry , vol.39 , pp. 167-71
    • Sorenson, J.L.1    Hargreaves, W.A.2    Weinberg, J.A.3
  • 15
    • 23444454815 scopus 로고    scopus 로고
    • Levo-alpha-acetylmethadol (LAAM) versus methadone: Treatment retention and opiate use
    • Longshore D., Annon J., Anglin M. D., Rawson R. A. Levo-alpha- acetylmethadol (LAAM) versus methadone: treatment retention and opiate use. Addiction 2005 100 : 1131 9.
    • (2005) Addiction , vol.100 , pp. 1131-9
    • Longshore, D.1    Annon, J.2    Anglin, M.D.3    Rawson, R.A.4
  • 16
    • 5444262417 scopus 로고    scopus 로고
    • Evaluation of levo-alpha-acetylmethadol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: A pharmacokinetic and pharmacodynamic analysis
    • Newcombe D. A. L., Bochner F., White J. M., Somogyi A. A. Evaluation of levo-alpha-acetylmethadol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis. Drug Alcohol Depend 2004 76 : 63 72.
    • (2004) Drug Alcohol Depend , vol.76 , pp. 63-72
    • Newcombe, D.A.L.1    Bochner, F.2    White, J.M.3    Somogyi, A.A.4
  • 17
    • 0030916403 scopus 로고    scopus 로고
    • Dose-related efficacy of levo-methadyl-acetate for treatment of opioid dependence. a randomized clinical trial
    • Eissenberg T., Bigelow G. E., Strain E. C., Walsh S. L., Brooner R. K., Stitzer M. L. et al. Dose-related efficacy of levo-methadyl-acetate for treatment of opioid dependence. A randomized clinical trial. JAMA 1997 277 : 1945 51.
    • (1997) JAMA , vol.277 , pp. 1945-51
    • Eissenberg, T.1    Bigelow, G.E.2    Strain, E.C.3    Walsh, S.L.4    Brooner, R.K.5    Stitzer, M.L.6
  • 18
    • 0022972450 scopus 로고
    • Clinical experiences with 959 opioid-dependent patients treated with levo-alpha-acetylmethadol (LAAM)
    • Tennant F. S., Rawson R. A., Pumphrey E., Seecof R. Clinical experiences with 959 opioid-dependent patients treated with levo-alpha-acetylmethadol (LAAM). JAMA 1986 3 : 195 202.
    • (1986) JAMA , vol.3 , pp. 195-202
    • Tennant, F.S.1    Rawson, R.A.2    Pumphrey, E.3    Seecof, R.4
  • 19
    • 0043092376 scopus 로고    scopus 로고
    • Pharmacologic Treatments for Heroin and Cocaine Dependence
    • Kleber H. D. Pharmacologic Treatments for Heroin and Cocaine Dependence. Am J Addict 2003 12 : S5 18.
    • (2003) Am J Addict , vol.12
    • Kleber, H.D.1
  • 20
    • 0036312309 scopus 로고    scopus 로고
    • The gap between research and practice in substance abuse treatment
    • Marinelli-Casey P., Domier C. P., Rawson R. A. The gap between research and practice in substance abuse treatment. Psychiatr Serv 2002 53 : 984 7.
    • (2002) Psychiatr Serv , vol.53 , pp. 984-7
    • Marinelli-Casey, P.1    Domier, C.P.2    Rawson, R.A.3
  • 21
    • 0031968299 scopus 로고    scopus 로고
    • A 3-year progress report on the implementation of LAAM in the United States
    • Rawson R. A., Hasson A. L., Huber A. M., McCann M. J., Ling W. A 3-year progress report on the implementation of LAAM in the United States. Addiction 1998 93 : 533 40.
    • (1998) Addiction , vol.93 , pp. 533-40
    • Rawson, R.A.1    Hasson, A.L.2    Huber, A.M.3    McCann, M.J.4    Ling, W.5
  • 22
    • 0035182750 scopus 로고    scopus 로고
    • Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM)
    • Deamer R. L., Wilson D. R., Clark D. S., Prichard J. G. Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM). J Addict Dis 2001 20 : 7 14.
    • (2001) J Addict Dis , vol.20 , pp. 7-14
    • Deamer, R.L.1    Wilson, D.R.2    Clark, D.S.3    Prichard, J.G.4
  • 23
    • 33846201597 scopus 로고    scopus 로고
    • Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients-a cross-sectional study
    • Peles E., Bodner G., Kreek M. J., Rados V., Adelson. M. Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients-a cross-sectional study. Addiction 2006 102 : 289 300.
    • (2006) Addiction , vol.102 , pp. 289-300
    • Peles, E.1    Bodner, G.2    Kreek, M.J.3    Rados, V.4    Adelson., M.5
  • 24
    • 34547844860 scopus 로고    scopus 로고
    • The European Agency for the Evaluation of Medicinal Products. EMEA Public Statement of the Recommendation to Suspend the Marketing Authorization Fro ORLAAM (Levacetylmethadol) in the. European Union. Available at: (accessed 5 April 2007).
    • The European Agency for the Evaluation of Medicinal Products. EMEA Public Statement of the Recommendation to Suspend the Marketing Authorization Fro ORLAAM (Levacetylmethadol) in the. European Union. Available at: http://www.emea.europa.eu/pdfs/human/press/pus/877601en.pdf (accessed 5 April 2007).
  • 26
    • 34547834725 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration (FDA) Talk Paper T01-15. FDA Announces Labeling Changes Following Cardiac Adverse Events with Addiction Drug (April 20, 2001).Available at: (accessed 15 March 2006).
    • U.S. Food and Drug Administration (FDA) Talk Paper T01-15. FDA Announces Labeling Changes Following Cardiac Adverse Events with Addiction Drug (April 20, 2001).Available at: http://www.fda.gov/bbs/topics/answers/2001/ans01076.html (accessed 15 March 2006).
  • 27
    • 0005436776 scopus 로고    scopus 로고
    • Comparison of the effects of methadone and LAAM on the electrocardiogram
    • Huber A., Ling W., Fradis J., Charuvastra V. C. Comparison of the effects of methadone and LAAM on the electrocardiogram. Drug Alcohol Depend 2001 63 : S70.
    • (2001) Drug Alcohol Depend , vol.63
    • Huber, A.1    Ling, W.2    Fradis, J.3    Charuvastra, V.C.4
  • 28
    • 34547853024 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration Product Discontinuation Notice NDC 0054-3649-63 (August 23, 2003). Available at: (accessed 15 March 2006).
    • U.S. Food and Drug Administration Product Discontinuation Notice NDC 0054-3649-63 (August 23, 2003). Available at: http://www.fda.gov/cder/drug/ shortages/orlaam.htm (accessed 15 March 2006).
  • 29
    • 34547845854 scopus 로고    scopus 로고
    • Agonist pharmacotherapies for opiate dependence: Comparing the development and implementation of methadone and LAAM
    • In: Sorensen, J. L., Rawson, R., Guydish, J., Zweben, J., editors. Washington, DC: American Psychological Association. p.
    • Ling W., Rawson R. A., Anglin M. D. Agonist pharmacotherapies for opiate dependence: comparing the development and implementation of methadone and LAAM. In : Sorensen J. L., Rawson R., Guydish J., Zweben J., editors. Drug Abuse Treatment Through Collaboration. Washington, DC : American Psychological Association 2002, p. 107 19.
    • (2002) Drug Abuse Treatment Through Collaboration. , pp. 107-19
    • Ling, W.1    Rawson, R.A.2    Anglin, M.D.3
  • 30
    • 19544368020 scopus 로고    scopus 로고
    • An overview of systematic reviews of the effectiveness of opiate maintenance therapies: Available evidence to inform clinical practice and research
    • Amato L., Davoli M., Perucci C. A., Ferri M., Faggiano F., Mattick R. P. An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research. J Subst Abuse Treat 2005 28 : 321 9.
    • (2005) J Subst Abuse Treat , vol.28 , pp. 321-9
    • Amato, L.1    Davoli, M.2    Perucci, C.A.3    Ferri, M.4    Faggiano, F.5    Mattick, R.P.6
  • 31
    • 0036470906 scopus 로고    scopus 로고
    • Retention rate and illicit opioid use during methadone maintenance interventions: A meta-analysis
    • Farré M., Mas A., Torrens A., Moreno V., Cami J. Retention rate and illicit opioid use during methadone maintenance interventions: a meta-analysis. Drug Alcohol Depend 2002 65 : 283 90.
    • (2002) Drug Alcohol Depend , vol.65 , pp. 283-90
    • Farré, M.1    Mas, A.2    Torrens, A.3    Moreno, V.4    Cami, J.5
  • 32
    • 0242593827 scopus 로고    scopus 로고
    • A randomized trial comparing levo-alpha-acetylmethadol with methadone maintenance for patients in primary care settings in Australia
    • Ritter A., Lintzeris N., Clark N., Jozica J., Kutin J. J., Bammer G. et al. A randomized trial comparing levo-alpha-acetylmethadol with methadone maintenance for patients in primary care settings in Australia. Addiction 2003 98 : 1605 13.
    • (2003) Addiction , vol.98 , pp. 1605-13
    • Ritter, A.1    Lintzeris, N.2    Clark, N.3    Jozica, J.4    Kutin, J.J.5    Bammer, G.6
  • 33
    • 0031438970 scopus 로고    scopus 로고
    • Methadone versus 1-alpha-acetylmethadol (LAAM) in the treatment of opiate addiction
    • Glanz M., Klawansky S., McAullife W., Chalmers T. Methadone versus 1-alpha-acetylmethadol (LAAM) in the treatment of opiate addiction. Am J Addict 1997 4 : 339 49.
    • (1997) Am J Addict , vol.4 , pp. 339-49
    • Glanz, M.1    Klawansky, S.2    McAullife, W.3    Chalmers, T.4
  • 34
    • 0031735180 scopus 로고    scopus 로고
    • Effects of LAAM dose on opiate use in opioid-dependent patients: A pilot study
    • Oliveto A. H., Farren C., Kosten T. R. Effects of LAAM dose on opiate use in opioid-dependent patients: a pilot study. Am J Addict 1998 7 : 272 82.
    • (1998) Am J Addict , vol.7 , pp. 272-82
    • Oliveto, A.H.1    Farren, C.2    Kosten, T.R.3
  • 36
    • 0027265386 scopus 로고
    • Some conceptual and statistical issues in analysis of longitudinal psychiatric data: Application to the NIMH treatment of depression collaborative research program dataset
    • Gibbons R. D., Hedeker D., Elkin I., Waternaux C., Kraemer H. C., Greenhouse J. B. et al. Some conceptual and statistical issues in analysis of longitudinal psychiatric data: application to the NIMH treatment of depression collaborative research program dataset. Arch Gen Psychiatry 1993 50 : 739 50.
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 739-50
    • Gibbons, R.D.1    Hedeker, D.2    Elkin, I.3    Waternaux, C.4    Kraemer, H.C.5    Greenhouse, J.B.6
  • 37
    • 0028650772 scopus 로고
    • A random-effects ordinal regression model for multilevel analysis
    • Hedeker D., Gibbons R. D. A random-effects ordinal regression model for multilevel analysis. Biometrics 1994 50 : 933 44.
    • (1994) Biometrics , vol.50 , pp. 933-44
    • Hedeker, D.1    Gibbons, R.D.2
  • 40
    • 0033669429 scopus 로고    scopus 로고
    • Analysis of longitudinal substance use outcomes using ordinal random-effects regression models
    • Hedeker D., Mermelstein R. J. Analysis of longitudinal substance use outcomes using ordinal random-effects regression models. Addiction 2000 95 : S381 94.
    • (2000) Addiction , vol.95
    • Hedeker, D.1    Mermelstein, R.J.2
  • 41
    • 0021730579 scopus 로고
    • Random-effects models for serial observations with binary response
    • Stiratelli R., Laird N. M., Ware J. H. Random-effects models for serial observations with binary response. Biometrics 1984 40 : 961 71.
    • (1984) Biometrics , vol.40 , pp. 961-71
    • Stiratelli, R.1    Laird, N.M.2    Ware, J.H.3
  • 42
    • 0002105479 scopus 로고    scopus 로고
    • Application of random-effects pattern-mixture models for missing data in longitudinal studies
    • Hedeker D., Gibbons R. D. Application of random-effects pattern-mixture models for missing data in longitudinal studies. Psychol Methods 1997 2 : 64 78.
    • (1997) Psychol Methods , vol.2 , pp. 64-78
    • Hedeker, D.1    Gibbons, R.D.2
  • 43
    • 34547845855 scopus 로고    scopus 로고
    • R Development Core Team.The Comprehensive R Archive Network. Available at: (accessed 13 April 2006).
    • R Development Core Team. The Comprehensive R Archive Network. Available at: http://cran.r-project.org/ (accessed 13 April 2006).
  • 44
    • 3042760400 scopus 로고    scopus 로고
    • National Institutes of Health (NIH). NIH Consensus Statement, 17-19 November. Bethesda, MD: NIH
    • National Institutes of Health (NIH). NIH Consensus Statement, 17-19 November. Effective Medical Treatment of Opiate Addiction. Bethesda, MD : NIH 1997.
    • (1997) Effective Medical Treatment of Opiate Addiction.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.