Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 2, 2007, Pages

  Kaneko, Shiho ^a   Okuda Ashitaka, Emiko ^a   Ando, Akira ^a   Nishimura, Kazuhiro ^b   Igarashi, Kazuei ^b   Maeda, Masahide ^c   Furuta, Kyoji ^c   Suzuki, Masaaki ^c   Matsumura, Miyo ^a   Ito, Seiji ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

c myc; Ornithine decarboxylase; Ornithine transport

Indexed keywords

AMINO ACID TRANSPORTER; EFLORNITHINE; MESSENGER RNA; MYC PROTEIN; ORNITHINE; ORNITHINE DECARBOXYLASE; ORNITHINE OXOACID AMINOTRANSFERASE; POLYAMINE DERIVATIVE; SMALL INTERFERING RNA; SPERMINE; TELOMERASE;

AMINO ACID TRANSPORT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS;

ANIMALS; CATIONIC AMINO ACID TRANSPORTER 1; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EFLORNITHINE; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; ORNITHINE; ORNITHINE DECARBOXYLASE; ORNITHINE-OXO-ACID TRANSAMINASE; PIGMENT EPITHELIUM OF EYE; PROTO-ONCOGENE PROTEINS C-MYC; PUTRESCINE; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SPERMIDINE; SPERMINE; SWINE; TELOMERASE; TIME FACTORS; TRANSFECTION; UP-REGULATION;

SUS;

EID: 34547817073     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00018.2007     Document Type: Article

References (53)

1. Agostinelli E, Arancia G, Vedova LD, Belli F, Marra M, Salvi M, Toninello A. The biological functions of polyamine oxidation products by amine oxidases: perspectives of clinical applications. Amino Acids 27: 347-358, 2004.
2. Amati B, Littlewood TD, Evan GI, Land H. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J 12: 5083-5087, 1993.
3. Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature 359: 423-426, 1992.
4. +L of human erythrocytes: specificity and cation dependence of the translocation step. J Membr Biol 141: 183-192, 1994.
5. Aulak KS, Mishra R, Zhou L, Hyatt SL, de Jonge W, Lamers W, Snider M, Hatzoglou M. Post-transcriptional regulation of the arginine transporter Cat-1 by amino acid availability. J Biol Chem 274: 30424-30432, 1999.
6. Bello-Fernandez C, Packham G, Cleveland JL. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci USA 90: 7804-7808, 1993.
7. Blackwood EM, Eisenman RN. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251: 1211-1217, 1991.
8. Celano P, Baylin SB, Casero RA Jr. Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells. J Biol Chem 264: 8922-8927, 1989.
9. Childs AC, Mehta DJ, Gerner EW. Polyamine-dependent gene expression. Cell Mol Life Sci 60: 1394-1406, 2003.
10. Closs EI. Expression, regulation and function of carrier proteins for cationic amino acids. Curr Opin Nephrol Hypertens 11: 99-107, 2002.
11. Closs EI, Albritton LM, Kim JW, Cunningham JM. Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. J Biol Chem 268: 7538-7544, 1993.
12. Closs EI, Simon A, Vekony N, Rotmann A. Plasma membrane transporters for arginine. J Nutr 134: 2752S-2759S, 2004.
13. Deves R, Angelo S, Chavez P. N-ethylmaleimide discriminates between two lysine transport systems in human erythrocytes. J Physiol 468: 753-766, 1993.
14. Durante W, Liao L, Iftikhar I, Cheng K, Schafer AI. Platelet-derived growth factor regulates vascular smooth muscle cell proliferation by inducing cationic amino acid transporter gene expression. J Biol Chem 271: 11838-11843, 1996.
15. Durante W, Liao L, Peyton KJ, Schafer AI. Thrombin stimulates vascular smooth muscle cell polyamine synthesis by inducing cationic amino acid transporter and ornithine decarboxylase gene expression. Circ Res 83: 217-223, 1998.
16. Durante W, Liao L, Peyton KJ, Schafer AI. Lysophosphatidylcholine regulates cationic amino acid transport and metabolism in vascular smooth muscle cells. Role in polyamine biosynthesis. J Biol Chem 272: 30154-30159, 1997.
17. Fernandez J, Lopez AB, Wang C, Mishra R, Zhou L, Yaman I, Snider MD, Hatzoglou M. Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress. J Biol Chem 278: 50000-50009, 2003.
18. Fernandez J, Yaman I, Merrick WC, Koromilas A, Wek RC, Sood R, Hensold J, Hatzoglou M. Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame. J Biol Chem 277: 2050-2058, 2002.
19. Henriksson M, Luscher B. Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res 68: 109-182, 1996.
20. Hyatt SL, Aulak KS, Malandro M, Kilberg MS, Hatzoglou M. Adaptive regulation of the cationic amino acid transporter-1 (Cat-1) in Fao cells. J Biol Chem 272: 19951-19957, 1997.
21. Igarashi K, Kashiwagi K. Polyamines: mysterious modulators of cellular functions. Biochem Biophys Res Commun 271: 559-564, 2000.
22. Igarashi K, Kashiwagi K, Hamasaki H, Miura A, Kakegawa T, Hirose S, Matsuzaki S. Formation of a compensatory polyamine by Escherichia coli polyamine-requiring mutants during growth in the absence of polyamines. J Bacteriol 166: 128-134, 1986.
23. Kaiser-Kupfer MI, Caruso RC, Valle D. Gyrate atrophy of the choroid and retina. Long-term reduction of ornithine slows retinal degeneration. Arch Ophthalmol 109: 1539-1548, 1991.
24. Kanai Y, Segawa H, Miyamoto Uchino HK, Takeda E, Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 273: 23629-23632, 1998.
25. Kaneko S, Ando A, Okuda-Ashitaka E, Maeda M, Furuta K, Suzuki M, Matsumura M, Ito S. Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 48: 464-471, 2007.
26. Kaneko S, Ueda-Yamada M, Ando A, Matsumura S, Okuda-Ashitaka E, Matsumuea M, Uyama M, Ito S. Cytotoxic effect of spermine on retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 48: 455-463, 2007.
27. Kilberg MS, Barbosa-Tessmann IP. Genomic sequences necessary for transcriptional activation by amino acid deprivation of mammalian cells. J Nutr 132: 1801-1804, 2002.
28. Liu L, Li L, Rao JN, Zou T, Zhang HM, Boneva D, Bernard MS, Wang JY. Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation. Am J Physiol Cell Physiol 288: C89-C99, 2005.
29. Liu XM, Reyna SV, Ensenat D, Peyton KJ, Wang H, Schafer AI, Durante W. Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth. FASEB J 18: 768-770, 2004.
30. Mann GE, Yudilevich DL, Sobrevia L. Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83: 183-252, 2003.
31. Moinard C, Cynober L, de Bandt JP. Polyamines: metabolism and implications in human diseases. Clin Nutr 24: 184-197, 2005.
32. Muscari C, Bonafe' F, Farruggia G, Stanic I, Gamberini C, Carboni M, Basile I, Giordano E, Caldarera CM, Guarnieri C. Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells. Stem Cells 23: 983-991, 2005.
33. Nakamura E, Sato M, Yang H, Miyagawa F, Harasaki M, Tomita K, Matsuoka S, Noma A, Iwai K, Minato N. 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem 274: 3009-3016, 1999.
34. Nakauchi T, Ando A, Ueda-Yamada M, Yamasaki Y, Uyama M, Matsumura M, Ito S. Prevention of ornithine cytotoxicity by nonpolar side chain amino acids in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 44: 5023-5028, 2003.
35. Okuda-Ashitaka E, Tachibana S, Houtani T, Minami T, Masu Y, Nishi M, Takeshima H, Sugimoto T, Ito S. Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus. Mol Brain Res 43: 96-104, 1996.
36. Peraino C, Bunville LG, Tahmisian TN. Chemical, physical, and morphological properties of ornithine Aminotransferase from rat liver. J Biol Chem 244: 2241-2449, 1969.
37. Pyronnet S, Pradayrol L, Sonenberg N. Alternative splicing facilitates internal ribosome entry on the ornithine decarboxylase mRNA. Cell Mol Life Sci 62: 1267-1274, 2005.
38. Raina A, Janne J. Biosynthesis of putrescine: characterization of ornithine decarboxylase from regenerating rat liver. Acta Chem Scand 22: 2375-2378, 1968.
39. Rambhatla L, Chiu CP, Glickman RD, Rowe-Rendleman C. In vitro differentiation capacity of telomerase immortalized human RPE cells. Invest Ophthalmol Vis Sci 43: 1622-1630, 2002.
40. Sakata K, Kashiwagi K, Sharmin S, Ueda S, Igarashi K. Acrolein produced from polyamines as one of the uraemic toxins. Biochem Soc Trans 31: 371-374, 2003.
41. Sang J, Lim YP, Panzica M, Finch P, Thompson NL. TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation. Cancer Res 55: 1152-1159, 1995.
42. Schipper RG, Penning LC, Verhofstad AA. Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors? Semin Cancer Biol 10: 55-68, 2000.
43. +-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274: 19745-19751, 1999.
44. Seiler N, Raul F. Polyamines and apoptosis. J Cell Mol Med 9: 623-642, 2005.
45. Simell O, Takki K. Raised plasma-ornithine and gyrate atrophy of the choroid and retina. Lancet 1: 1031-1033, 1973.
46. Singh RK, Rinehart CA, Kim JP, Tolleson-Rinehart S, Lawing LF, Kaufman DG, Siegal GP. Tumor cell invasion of basement membrane in vitro is regulated by amino acids. Cancer Invest 14: 6-18, 1996.
47. Ueda M, Masu Y, Ando A, Maeda H, Del Monte MA, Uyama M, Ito S. Prevention of ornithine cytotoxicity by proline in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 39: 820-827, 1998.
48. Valle D, Simell O. The hyperornithinemias In: The Metabolic and Molecular Bases of Inherited Disease, 7th ed., edited by Scriver C, Beaudet A, Sly W, Valle D. New York: McGraw-Hill, 1995, p. 1147-1185.
49. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Pflügers Arch 447: 532-542, 2004.
50. Watanabe S, Kusama-Eguchi K, Kobayashi H, Igarashi K. Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver. J Biol Chem 266: 20803-20809, 1991.
51. Williams K. Interactions of polyamines with ion channels. Biochem J 325: 289-297, 1997.
52. Xie X, Tome ME, Gerner EW. Loss of intracellular putrescine pool-size regulation induces apoptosis. Exp Cell Res 230: 386-392, 1997.
53. Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, Cha SH, Matsuo H, Fukushima J, Fukasawa Y, Tani Y, Taketani Y, Uchino H, Kim JY, Inatomi J, Okayasu I, Miyamoto K, Takeda E, Goya T, Endou H. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 1514: 291-302, 2001.