A minimal element in 5′UTR of insulin mRNA mediates its translational regulation by glucose

FEBS Letters

Volumn 581, Issue 21, 2007, Pages 4103-4108

  Muralidharan, Bhavana ^a   Bakthavachalu, Baskar ^a   Pathak, Anuj ^a   Seshadri, Vasudevan ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

5 UTR; Insulin; Translation

Indexed keywords

GLUCOSE; INSULIN; MESSENGER RNA; RENILLA LUCIFERIN 2 MONOOXYGENASE;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE SEQUENCE; GENE STRUCTURE; MUTATIONAL ANALYSIS; NONHUMAN; PANCREAS ISLET BETA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN RNA BINDING; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA STABILITY; TRANSLATION INITIATION; TRANSLATION REGULATION;

5' UNTRANSLATED REGIONS; ANIMALS; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; NUCLEIC ACID CONFORMATION; ORGAN SPECIFICITY; PROTEIN BIOSYNTHESIS; RATS; RATS, WISTAR; RNA-BINDING PROTEINS;

RATTUS;

EID: 34547813069     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.07.050     Document Type: Article

References (13)

1. Goodge K.A., and Hutton J.C. Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell. Semin. Cell Dev.Biol. 11 (2000) 235-242
2. Itoh N., and Okamoto H. Translational control of proinsulin synthesis by glucose. Nature 283 (1980) 100-102
3. Itoh N., Sei T., Nose K., and Okamoto H. Glucose stimulation of the proinsulin synthesis in isolated pancreatic islets without increasing amount of proinsulin mRNA. FEBS Lett. 93 (1978) 343-347
4. Welsh M., Nielsen D.A., MacKrell A.J., and Steiner D.F. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J. Biol. Chem. 260 (1985) 13590-13594
5. Jahr H., Schroder D., Ziegler B., Ziegler M., and Zuhlke H. Transcriptional and translational control of glucose-stimulated (pro)insulin biosynthesis. Eur. J. Biochem. 110 (1980) 499-505
6. Grimaldi K.A., Siddle K., and Hutton J.C. Biosynthesis of insulin secretory granule membrane proteins. Control by glucose. Biochem. J. 245 (1987) 567-573
7. Guest P.C., Bailyes E.M., Rutherford N.G., and Hutton J.C. Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins. Biochem. J. 274 Pt 1 (1991) 73-78
8. Wicksteed B., Herbert T.P., Alarcon C., Lingohr M.K., Moss L.G., and Rhodes C.J. Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation. J. Biol. Chem. 276 (2001) 22553-22558
9. Tillmar L., Carlsson C., and Welsh N. Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3′-untranslated region pyrimidine-rich sequence. J. Biol. Chem. 277 (2002) 1099-1106
10. Permutt M.A., and Kipnis D.M. Insulin biosynthesis. I. On the mechanism of glucose stimulation. J. Biol. Chem. 247 (1972) 1194-1199
11. Knight S.W., and Docherty K. The identification of protein-RNA interactions within the 5′ untranslated region of human preproinsulin mRNA. Biochem. Soc. Trans. 19 (1991) 120S
12. Wicksteed B., Uchizono Y., Alarcon C., McCuaig J.F., Shalev A., and Rhodes C.J. A cis-element in the 5′ untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation. Cell Metab. 5 (2007) 221-227
13. Greenman I.C., Gomez E., Moore C.E., and Herbert T.P. The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells. Biochem. J. 391 (2005) 291-300