Retention prediction of adrenoreceptor agonists and antagonists on a diol column in hydrophilic interaction chromatography

Analytica Chimica Acta

Volumn 598, Issue 1, 2007, Pages 41-50

  Quiming, Noel S ^a,b   Denola, Nerissa L ^a,b   Ueta, Ikuo ^a   Saito, Yoshihiro ^a   Tatematsu, Satoshi ^c   Jinno, Kiyokatsu ^a  

^a TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

^b UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Adrenoreceptors agonists antagonists; Artificial neural network; Hydrophilic interaction chromatography; Mulitiple linear regression; Quantitative structure retention relationships

Indexed keywords

HYDROPHILICITY; MATHEMATICAL MODELS; NEURAL NETWORKS; PH EFFECTS;

ADRENORECEPTORS AGONISTS/ANTAGONISTS; HYDROPHILIC INTERACTION CHROMATOGRAPHY; MULITIPLE LINEAR REGRESSION; QUANTITATIVE STRUCTURE-RETENTION RELATIONSHIPS;

LINEAR REGRESSION;

ACEBUTOLOL; ACETONITRILE; ADRENERGIC RECEPTOR BLOCKING AGENT; ADRENERGIC RECEPTOR STIMULATING AGENT; ALPRENOLOL; ATENOLOL; BAMBUTEROL; BETAXOLOL; CARVEDILOL; ISOXSUPRINE; METHOXAMINE; METOPROLOL; MIDODRINE; NADOLOL; ORCIPRENALINE; OXYMETAZOLINE; PHENYLEPHRINE; PINDOLOL; PROPRANOLOL; RITODRINE; SALBUTAMOL; SOTALOL; TIMOLOL;

ARTICLE; ARTIFICIAL NEURAL NETWORK; CHEMICAL INTERACTION; CHROMATOGRAPHY; DRUG RETENTION; HYDROGEN BOND; HYDROPHILIC INTERACTION CHROMATOGRAPHY; ION TRANSPORT; MATHEMATICAL MODEL; MULTIPLE LINEAR REGRESSION ANALYSIS; PARTITION COEFFICIENT; PH MEASUREMENT; PRIORITY JOURNAL; SURFACE CHARGE; TOTAL ABSOLUTE ATOMIC CHARGE OF THE MOLECULE;

ADRENERGIC AGONISTS; ADRENERGIC ANTAGONISTS; CHROMATOGRAPHY; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; NEURAL NETWORKS (COMPUTER); REGRESSION ANALYSIS; WATER;

EID: 34547771598     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aca.2007.07.039     Document Type: Article

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