Biweekly administration of docetaxel and gemcitabine as adjuvant therapy for stage II and IIIA non-small cell lung cancer: A phase II study

Anticancer Research

Volumn 27, Issue 4 C, 2007, Pages 2887-2892

  Syrigos, Konstantinos N ^a,c   Konstantinou, Marios ^a   Sepsas, Evangellos ^a   Papamichales, George ^a   Loullias, Achilleas ^a   Belenis, Ionas ^b   Skottis, Ionas ^a   Charpidou, Andriani ^a   Roussos, Charalambos ^b  

^a SOTIRIA GENERAL HOSPITAL   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Adjuvant chemotherapy; Combined modality treatment; Non platinum regimen; Non small cell lung carcinoma

Indexed keywords

DEXAMETHASONE; DOCETAXEL; GEMCITABINE; ONDANSETRON; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; ALOPECIA; ANEMIA; ARTICLE; BRAIN METASTASIS; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MALE; NAUSEA; NEUROTOXICITY; NEUTROPENIA; PATIENT COMPLIANCE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SKIN DISEASE; TREATMENT FAILURE; TREATMENT OUTCOME;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CHEMOTHERAPY, ADJUVANT; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; TAXOIDS;

EID: 34547771235     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Padley S: Radiological diagnosis and staging of lung cancer. In: Tumor of the Chest. Biology, Diagnosis and Management. Syrigos KN, Nutting C and Roussos C (eds.). New York, Springer, pp. 127-144, 2006.
2. Burdett S and Stewart L: Postoperative radiotherapy in non-small cell lung cancer: update on an individual patient data meta-analysis. Lung Cancer 47: 81-83, 2005.
3. Pisters KMW: Adjuvant chemotherapy for NSCLC-The smoke clears. N Engl J Med 352: 25, 2640-2642, 2005.
4. The International Adjuvant Lung Cancer Trial Collaborative Group: Cisplatin-based adjuvant chemotherapy in patients with completely resected non small-cell lung cancer. N Engl J Med 350: 351-360, 2004.
5. Strauss GM, Herndon J, Maddaus MA, Johnstone DW, Watson DM, Sugarbaker DJ, Schilsky RA, Vokes EE and Green MR: Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection in stage IB non-small cell lung cancer (NSCLC): report of Cancer and Leukemia Group B (CALGB) protocol 9633. J Clin Oncol 22(Suppl 14S): 621s, 2004. [abstract].
6. Pisters KMW and Le Chevalier T: Adjuvant chemotherapy in completely resected NSCLC. J Clin Oncol 23: 3270-3278, 2005.
7. Douillard JY, Lerouge D, Monnier A, Bennouana J, Haller AM, Sun XS, Assouline D, Grau B and Riviere A: Combined paclitaxel and gemcitabine as first-line treatment in metastatic non-small cell lung cancer: a multicentre phase II study. Br J Cancer 84: 1179-1184, 2001.
8. Laack E, Mende T, Benk J, Chemaissani A, Scholtze J, Lorenz C, Niestroy A, Dalhoff K, Muller T, Walter T, Durk H, Elder L and Hossfeld DK: Gemcitabine and vinorelbine as first-line chemotherapy for advanced non-small cell lung cancer: a phase II trial. Eur J Cancer 37: 583-590, 2001.
9. James K, Eisnhauer E, Christian M, Terenziani M, Vera D, Mulda JA and Therasse P: Measuring response in solid tumors: unidimensional versus bidimensional measurement. J Natl Cancer Inst 91(6): 523-528, 1999.
10. Dautzenberg B, Arriagada R, Chammard AB, Jarema A, Mezzetti M, Mattson K, Lagrange JL, Le Pechoux C, Lebeau B and Chastang C: A controlled study of postoperative radiotherapy for patients with completely resected non small cell lung carcinoma. Cancer 86: 265-273, 1999.
11. Casas F, Zimmermann FB, Perin B and Jeremic B: Integration of radiotherapy in the management of locally advanced NSCLC. In: Tumor of the Chest. Biology, Diagnosis and Management. Syrigos KN, Nutting C and Roussos C (eds.). New York, Springer, pp. 237-247, 2006.
12. Bekelman JE, Rosenzweig KE, Bach PB and Schrag D: Trends in the use of postoperative radiotherapy for resected non-small cell lung cancer. Int J Radiat Oncol Biol Phys 29: 1241-1244, 2006.
13. PORT Meta-analysis Trialists Group: Postoperative radiotherapy in non-small cell lung cancer: Systematic review and meta-analysis of individual patient data from nine randomised clinical trials. Lancet 352: 257-263, 1998.
14. Non-Small Cell Lung Cancer Collaborative Group: Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 311: 899-909, 1995.
15. Martoni AA, Di Fabio F, Melotti B, Giaquinta S and Guaraldi M: Planned sequence of gemcitabine followed by vinorelbine in the treatment of elderly patients with advanced non-small cell lung cancer. Anticancer Res 26: 1501-1506, 2006.
16. Georgoulias V, Ardavanis A, Agelidou A, Agelidou M, Chandrinos V, Tsaroucha E, Toumbis M, Kourousis C, Syrigos KN, Polyzos A, Samaras N, Papakotoulas P, Christofilakis C, Ziras N and Alagakis A: Docetaxel versus docetaxel plus cisplatin as front-line treatment of patients with advanced non-small-cell lung cancer: a randomized, multicenter phase III trial. J Clin Oncol 22: 2602-2609, 2004.
17. De Petris L, Migliorino MR, Ceribelli A, Martelli O, Di Molfetta M and De Martinis F: Docetaxel administered every two weeks as second line chemotherapy for advanced non-small cell lung cancer: phase II study. Anticancer Res 25: 4713-4717, 2005.
18. Fossella F, Pereira JR, von Pawel J, Pluzanska A, Gordounova V, Kankel E, Mattson KV, Ramlau R, Szezesna A, Fidias P, Millward M and Belani CP: Randomized multinational phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small cell lung cancer. J Clin Oncol 21: 3016-3024, 2003.
19. Scagliotti GV and Selvaggi G: Non-platinum based chemotherapy for advanced non-small cell lung cancer. In: Tumor of the Chest. Biology, Diagnosis and Management. Syrigos KN, Nutting C and Roussos C (eds.). New York, Springer, pp. 289-299, 2006.
20. Israel V, Tagawa ST, Snyder T, Jeffers S and Raghavan D: Phase I/II trial of gemcitabine plus docetaxel in advanced non-small cell lung cancer (NSCLC). Invest New Drugs 22: 291-297, 2004.
21. De Castro J, Lorenzo A, Morales S, Belon J, Dorta J, Lizon J, Madronal C, Gallurt PM, Casado E, Feliu J and Boran MG: Phase II study of a fixed dose-rate infusion of gemcitabine associated with docetaxel in advanced non-small-cell lung carcinoma. Cancer Chemother Pharmacol 55: 197-202, 2005.
22. Dimopoulou I, Bamias A, Lymperopoulos P and Dimopoulos MA: Pulmonary toxicity from novel antineoplastic agents. Ann Oncol 17: 372-379, 2006.
23. Syrigos KN, Dannos I, Dionellis G, Bofos I, Alamara C, Dimakou E, Stratakos G and Papiris S: Bi-weekly administration of docetaxel and gemcitabine as first-line therapy for non-small cell lung cancer: a phase II study. Anticancer Res 25(5): 3489-3494, 2005.
24. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J and Johnson DH: Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med 346: 92-98, 2002.
25. Neubauer MA, Garfield DH, Kuerfler PR, Raju RN, Lindquist DL, Soo EW, Khan M, Boehm KA and Asmar L: Results of a phase II multicenter trial of weekly docetaxel and gemcitabine as first-line therapy for patients with advanced non-small cell lung cancer. Lung Cancer 47: 121-127, 2005.
26. Natale RB: Gemcitabine-containing regimens vs. others in first-line treatment of NSCLC. Oncology 18: 27-31, 2004.
27. Bradley JD, Paulus R, Graham MV, Ettinger DS, Johnstone DW, Pilepich MV, Machtay M, Komaki R, Atkins J and Curran WJ: Phase II trial of postoperative adjuvant paclitaxel/carboplatin and thoracic radiotherapy in resected stage II and IIIA NSCLC: Promising long-term results of the radiation therapy oncology group-RTOG 9705. J Clin Oncol 23: 3480-3487, 2005.
28. Arriagada R, Bergman B, Dunant A, Le Chevalier T, Pignon JP and Vansteenkiste J; International Adjuvant Lung Collaborative Group. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer. N Engl J Med 350: 351-360, 2004.
29. Tada H, Tsuchiya R, Ichinose Y, Koike T, Nishizawa N, Nagai K and Kato H: A randomized trial comparing adjuvant chemotherapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304). Lung Cancer 43(2): 167-173, 2004.