Divergent cyclisations of 2-(5-amino-4-carbamoyl-1H-pyrazol-3-yl)acetic acids with formyl and acetyl electrophiles

Tetrahedron

Volumn 63, Issue 39, 2007, Pages 9627-9634

  Smyth, Lynette A ^a   Matthews, Thomas P ^a   Horton, Peter N ^b   Hursthouse, Michael B ^b   Collins, Ian ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Cyclisation; Divergent synthesis; Heterocycle; One carbon electrophile; Tautomerism

Indexed keywords

2 (1 METHYL 4 OXO 4,5 DIHYDRO 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL)ACETIC ACID; 2 (5 AMINO 4 CARBAMOYL 1 METHYL 1H PYRAZOL 3 YL)ACETIC ACID; 2 (5 AMINO 4 CARBAMOYL 1 PHENYL 1H PYRAZOL 3 YL)ACETIC ACID; ACETIC ACID DERIVATIVE; FORMIC ACID; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CHEMICAL REACTION KINETICS; CYCLIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

EID: 34547770755     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.07.034     Document Type: Article

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