Determination of flurbiprofen solubility in a wax-based matrix using hyperDSC, Higuchi release kinetics and microscopy

Chemical Engineering Research and Design

Volumn 85, Issue 7 A, 2007, Pages 1039-1043

  Oladiran, G S ^a   Batchelor, H K ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Flurbiprofen; Higuchi kinetics; HyperDSC; Solubility

Indexed keywords

DRUG PRODUCTS; MELTING POINT; MICROSCOPIC EXAMINATION; REACTION KINETICS;

FLURBIPROFEN; HIGUCHI KINETICS; WAX-BASED MATRIX;

SOLUBILITY;

DRUG PRODUCTS; MELTING POINT; MICROSCOPIC EXAMINATION; REACTION KINETICS; SOLUBILITY;

EID: 34547769904     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1205/cherd06219     Document Type: Article

References (9)

1. Ahmed, A., Barry, B.W., Williams, A.C. and Davis, A.F., 2004, Penciclovir solubility in eudragit films: a comparison of x-ray, thermal, microscopic and release rate techniques, J Pharm Biomed Anal, 34(5): 945-956.
2. De Muynck, C. and Remon, J.P., 1992, Influence of fat composition on the melting behaviour and on the in vitro release of indomethacin suppositories, Int J Pharm, 85: 103-112.
3. David, S., 2005, Improving the solubility and dissolution of poorly soluble drugs by salt formation and the consequent effect on mechanical properties, PhD thesis, Aston University.
4. Gramaglia, D., Conway, B.R., Kett, V.L., Malcolm, R.K. and Batchelor, H.K., 2005, High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix, Int J Pharm, 301: 1-5.
5. Gabbott, P., Clarke, P., Mann, T, Royall, P.G. and Shergill, S., 2003, A high sensitivity, high-speed DSC technique: measurement of amorphous lactose, American Laboratory, 35: 17-22.
6. Higuchi, T, 1961, The release rate of medicaments from ointments bases containing drug in suspension, J Pharm Sci, 50: 874-5.
7. Rowe, R.C., Shewskey, P.J. and Owen, S.C., 2005, The Handbook of Pharmaceutical Excipients (Pharmaceutical Press, London, UK).
8. Saunders, M.H., Podluii, K., Shergill, S., Buckton, G. and Royall, P.G., 2004, The potential off high speed DSC (hyper-DSC) for the detection and quantification of small amounts of amorphous contents in predominantly crystalline samples, Int J Pharm, 274: 35-40.
9. Theeuwes, F., Hussain, A. and Higuchi, T., 1974, Quantitative analytical method for determination of drugs dispersed in polymers using differential scanning calorimetry, J Pharm Sci, 63: 427-429.