Novel lβ-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in vitro antibacterial activity

European Journal of Medicinal Chemistry

Volumn 42, Issue 9, 2007, Pages 1176-1183

  Kim, Seong Jong ^a   Park, Hyeong Beom ^b   Lee, Jae Seoung ^a   Jo, Nam Hyun ^a   Yoo, Kyung Ho ^a   Baek, Daejin ^c   Kang, Byoung won ^d   Cho, Jung Hyuck ^a   Oh, Chang Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Hanyang University   (South Korea)

^c Hanseo University   (South Korea)

^d Dong Eui University   (South Korea)

Author keywords

1 Methylcarbapenems; Antibacterial activity; Substituent effects

Indexed keywords

2 METHYL[1,2,6]THIADIAZINAN 1,1 DIOXIDE; 6 HYDROXYETHYL 2 [5 (5 METHYL 1,1 DIOXO[1,2,5]THIAZOLIDIN 2 YLMETHYL)] 1 (ALLYLOXYCARBONYL)PYRROLIDIN 3 YLTHIO 1 METHYLCARBAPEN 2 EM 3 CARBOXYLIC ACID; CARBAPENEM DERIVATIVE; IMIPENEM; MEROPENEM; OXIDE; SULFONAMIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; NONHUMAN; CHEMISTRY; INFRARED SPECTROSCOPY; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTI-BACTERIAL AGENTS; CARBAPENEMS; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 34547759867     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.02.001     Document Type: Article

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